DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8839 and faah-4

DIOPT Version :9

Sequence 1:	NP_610764.1	Gene:	CG8839 / 36340	FlyBaseID:	FBgn0033717	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_499545.1	Gene:	faah-4 / 176620	WormBaseID:	WBGene00013232	Length:	647	Species:	Caenorhabditis elegans

Alignment Length:	575	Identity:	146/575 - (25%)
Similarity:	239/575 - (41%)	Gaps:	118/575 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RLIYG-QKGESVPPITDAILLESATSLARKIRKQELSSVQVLESFIRRIKEVNPILNCVVDERYD 91
            |::.| :..|.:....:.||.....:|...::..:.::..||.:|:.|..:||..:||:.
Worm    72 RIVKGNETAEQIETTFNEILKLDLIALKSALQTDKYNAYTVLCAFVWRAIDVNSEINCIT----- 131

  Fly    92 QALKEA---AEA--DALIKSGQYSTEELEKEKPFLGVPITTKDCISVKGMLHTAGLFERRDVRAA 151
            :.::||   |||  |...::|       ||.:.| |:|.:.|....::....|.||.:..:....
Worm   132 EVIREAFNTAEALDDNYAQTG-------EKGQLF-GLPFSVKSNFYMENYDVTVGLAKLLEQPKT 188

  Fly   152 RDADAMALMRKAGAIPIALTNVSEVCMWWESNNTVHGRTRNAYDTNRIVGGSSGGEGCIQSAAAS 216
            .....:..:...||:|..||||.:..:.:.|:|.::|.|:|.:|.:|..|||||||..:.:|..:
Worm   189 TTCPMVQFLSDQGAVPFCLTNVPQGLLSYVSSNPIYGTTKNPWDFSRTPGGSSGGEAALLAAGGA 253

  Fly   217 AFGLGSDIGGSIRMPAFFNGIFGHKPS--KLVVSNV-------GQFPAPFS------AEQNSFLG 266
            |||:|||:.||:|:||.|.|:...||:  :|.|::.       |:....|.      .||...||
Worm   254 AFGIGSDLAGSLRIPAAFCGLVTLKPTQDRLCVTDTHGGLPGRGRLGLSFGFYTRSVKEQEFLLG 318

  Fly   267 L--GPMSRFAEDLRPMLKIMAGEKAALLNLDEDVDLTKMKFFYQESDGGGRLVSAVDPDLREAMN 329
            |  | .|.:.| |.||......||    ::::|   .|:...:...||    .:.|.|..|.|:.
Worm   319 LIVG-RSEYLE-LCPMSSPAKLEK----HIEKD---QKLVIGWFVDDG----FNPVVPSNRRAVE 370

  Fly   330 RVAQHLREKFGNQKVE------RIQLPHFRQSAAIWFANMRDDSGHGFAYQLGNLNHDIN----- 383
            ...:.|:.| |:|.||      ..:.|.| ..|.:.|.|:..|:|...:.......:|.:
Worm   371 ETVKSLQAK-GHQVVELKLADVSEEFPPF-AVADMLFRNVMPDNGAYMSEMYAGEQYDEHMKLFI 433

  Fly   384 -------TYLELFKWFFGASKHTFIGLSTAI--------MDSAQCKHGSPKYDHLVRKRNELREE 433
                   .:|..|...:|......:.||..:        .|.|.|:......|..  |...:|..
Worm   434 RLVCLKQNFLVSFLLRYGVMPFAKLALSKRLACIGSAYNSDLAACRQNQENTDSY--KLQWIRYW 496

  Fly   434 LQSLLGDNGVLIYPTHPTVAPYHNEPITRPI---NFAY-TGIVNVLGFPATAVPLGKL------- 487
            ....:   ..||.|:..|.|    :|...|.   |.|: ||:.|:|..||..||:..:
Worm   497 KSKKI---DALICPSFITPA----QPFEYPAQLSNGAFITGLFNMLDVPAGVVPVSPVNQKDVDQ 554

  Fly   488 ---------------------GSEGLPLGVQIIANFNQDRLCLAVAEELERAFGG 521
                                 |:.|||..||::...|.:.:||.|...:|.:..|
Worm   555 LIDGFSTEGDLLLKKQREAARGTTGLPNAVQVVTLPNCEEMCLRVMRLVEESAEG 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8839	NP_610764.1	GatA	42..525	CDD:223232	143/560 (26%)
CG8839	NP_610764.1	PRK07488	49..520	CDD:236030	140/550 (25%)
faah-4	NP_499545.1	Amidase	112..597	CDD:418511	135/521 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D852596at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X256
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920