DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Den1 and nep2

DIOPT Version :9

Sequence 1:	NP_001163126.1	Gene:	Den1 / 36339	FlyBaseID:	FBgn0033716	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_595608.1	Gene:	nep2 / 2540263	PomBaseID:	SPBC32H8.02c	Length:	415	Species:	Schizosaccharomyces pombe

Alignment Length:	270	Identity:	76/270 - (28%)
Similarity:	123/270 - (45%)	Gaps:	46/270 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LRQHTRQNQNTN--------RRRPRFTNNSF-HTKMGSNSKADP---ISLTFHDSCLRMSDVQLL 61
            ||..:..:.|:|        :::..|..:.| .:..||.|...|   |.|.:.:..||.:||...
pombe    22 LRPPSTGSSNSNGSDTASPKKKKKGFFRSLFGSSSSGSKSCGSPFTRIWLEYFEVSLRKNDVDHF 86

  Fly    62 HGPHWLNDQILSFYYE-----YLAHMKYKTNADLHFIAPEITQCMKYMGDQ-ELKQLL-----DQ 115
            ...:|:.|..:.|:||     .|.....:.:..::.:.|.:...:....:. |::..|     |.
pombe    87 RPGYWILDTNIDFFYEIMLRQVLLKRPKEESQQIYLLRPAMVFFLAQAPNPLEIESALPPAMFDA 151

  Fly   116 SNTTGKPFIFFALND-NETTDAGGSHWSLLVFSRPEKTFYHFDSYGNNNTGN-SLELMNKIKDLL 178
            |      |||..:|| ||.....||||||||.|..:...:::||..|.||.: :|.:.|     |
pombe   152 S------FIFLPINDTNECGIESGSHWSLLVVSVEKGLGWYYDSMSNGNTNDCNLAIKN-----L 205

  Fly   179 GVRMAK---FRPMRCLQQANGYDCGIHVICMTDHIADY--LNRYEV--ID-GLPSLHIDTVKAKR 235
            |:.:.|   .|.|:..||.|..|||:|| |....|..|  |.:..|  :| .|....:|:|:.::
pombe   206 GILLKKEFRVRHMKTPQQINDCDCGLHV-CENTRILMYRLLQKPYVPKVDMNLDHSVVDSVRLRK 269

  Fly   236 TELLKLILSL 245
            . |:::|.||
pombe   270 A-LMEVITSL 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Den1	NP_001163126.1	Peptidase_C48	66..204	CDD:304959	46/153 (30%)
nep2	NP_595608.1	Peptidase_C48	90..272	CDD:304959	56/194 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	67	1.000	Domainoid score	I2753
eggNOG	1	0.900	-	-		E1_COG2828
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004372
OrthoInspector	1	1.000	-	-		otm47140
orthoMCL	1	0.900	-	-		OOG6_103852
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R806
SonicParanoid	1	1.000	-	-		X4159
TreeFam	1	0.960	-	-
	9	8.700