DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Den1 and SENP8

DIOPT Version :9

Sequence 1:	NP_001163126.1	Gene:	Den1 / 36339	FlyBaseID:	FBgn0033716	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_001159812.1	Gene:	SENP8 / 123228	HGNCID:	22992	Length:	212	Species:	Homo sapiens

Alignment Length:	211	Identity:	77/211 - (36%)
Similarity:	121/211 - (57%)	Gaps:	4/211 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DPISLTFHDSCLRMSDVQLLHGPHWLNDQILSFYYEYLAHMKYKTNAD-LHFIAPEITQCMKYMG 105
            ||:.|::.||.||.|||.||..|.||||.|:.|.:||.|:.::...:| :.||:||:||.:|...
Human     2 DPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTS 66

  Fly   106 D-QELKQLLDQSNTTGKPFIFFALNDNETTDAGGSHWSLLVFSRPEKTFYHFDSYGNNNTGNSLE 169
            : .|:...|:..:...|..:|.|:|||....|||:||||||:.:.:.:|:|:||:..:|:.::.:
Human    67 NPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQ 131

  Fly   170 LMNKIKDLLGVRMAK--FRPMRCLQQANGYDCGIHVICMTDHIADYLNRYEVIDGLPSLHIDTVK 232
            :..|::..||.:..|  |...:...|.|.||||::|||.|:.:.....|.:....|..|....:.
Human   132 VAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYIT 196

  Fly   233 AKRTELLKLILSLGGK 248
            .||.|...||.:|..|
Human   197 KKRGEWKDLITTLAKK 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Den1	NP_001163126.1	Peptidase_C48	66..204	CDD:304959	50/141 (35%)
SENP8	NP_001159812.1	Protease	11..174		63/162 (39%)
SENP8	NP_001159812.1	Peptidase_C48	26..174	CDD:420019	54/147 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159393
Domainoid	1	1.000	109	1.000	Domainoid score	I6399
eggNOG	1	0.900	-	-		E1_COG2828
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14084
Inparanoid	1	1.050	139	1.000	Inparanoid score	I4521
Isobase	1	0.950	-	0	Normalized mean entropy	S3849
OMA	1	1.010	-	-		QHG54524
OrthoDB	1	1.010	-	-		D1313098at2759
OrthoFinder	1	1.000	-	-		FOG0004372
OrthoInspector	1	1.000	-	-		oto89220
orthoMCL	1	0.900	-	-		OOG6_103852
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R806
SonicParanoid	1	1.000	-	-		X4159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.650