DRSC/TRiP Functional Genomics Resources

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Protein Alignment garz and Arfgef2

DIOPT Version :9

Sequence 1:NP_610761.2 Gene:garz / 36337 FlyBaseID:FBgn0264560 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_001078964.1 Gene:Arfgef2 / 99371 MGIID:2139354 Length:1792 Species:Mus musculus


Alignment Length:1830 Identity:357/1830 - (19%)
Similarity:638/1830 - (34%) Gaps:530/1830 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 IEPQVFLAPFLEVIRTADATGPLTSLALASVNKLLSYGLIDPTSPNLA----DIVERIADAVTHA 121
            ||...:..||  .:.....:..:.|.:|..:.||::||.|...:|:..    .:::||.:.:.:.
Mouse    63 IEADKYFLPF--ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNC 125

  Fly   122 RFMGTDQSSDGVTFMRVIEVLHTLIRSP-----EGAAVSNVSMCEVMLSCFKISFEPRLSELLRR 181
             |.| .|:.:||. :::|:.|.|.:.||     ||..:..|.      :|:.|....: :.:.:.
Mouse   126 -FQG-PQTDEGVQ-LQIIKALLTAVTSPHIEIHEGTILQTVR------TCYNIYLASK-NLINQT 180

  Fly   182 SAEKSLKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRKSSAV 246
            :|:.:|..|:.:.|.|:       .:.:||:...:........|..:.:.|....:.:..|.|..
Mouse   181 TAKATLTQMLNVIFTRM-------ENQVLQEARELEKPMQSKPQSPVIQATAGSPKFSRLKQSQA 238

  Fly   247 EEPPQTPQSANLTVPGHL------------KAPILATTPASPAGNILDMQGK-----------IT 288
            :..|.||:.|.|....|.            :||....:|.|  |.....:|.           :.
Mouse   239 QSKPTTPEKAELPNGDHAQSGLGKVSLENGEAPRERGSPVS--GRAEPSRGTDSGAQEVVKDILE 301

  Fly   289 QTPTTTASTGEDETTVPETP----VIQVESTESEPLLDGETGEATSTLAEANSSEYINS------ 343
            ...|:......::..:||..    .::.:.....|.:|    |.:.|...|:..:.::|      
Mouse   302 DVVTSAVKEAAEKHGLPEPDRALGALECQECAVPPGVD----ENSQTNGIADDRQSLSSADNLEP 362

  Fly   344 ------VGVRFTQQSTDHDVTSLSPYGLPFIQELFRFLII--LC----NPLDKQNSDSMMH---- 392
                  |..||:.                 |.:...||:.  ||    .||.:...|...|    
Mouse   363 DVQGHQVAARFSH-----------------ILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRS 410

  Fly   393 --TGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLRG 455
              ..|.||....:.|......:|..:..:|..||..|.....|....:|...|.:...|..:.:.
Mouse   411 KVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKM 475

  Fly   456 HLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFES 520
            |||.|:|.:.:::...|. :...:.:|.|.:.:..|.::......|.::|:||||||...::||.
Mouse   476 HLKMQIEVFFKEIFLNIL-ETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFER 539

  Fly   521 LTNLLSKYTLSATNAVYSTHIISM-------------DTLLSVIDSI---ERNCAASKN--SSNN 567
            |.|.|||.....     |.|.:.|             :.|:|::..:   .::...:.|  ::..
Mouse   540 LVNDLSKIAQGR-----SGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQATLG 599

  Fly   568 RESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINASSHRLRLQSGGEGVGI 632
            :|.||:.....|                 .|..:|....|.::.|.:          |.|....|
Mouse   600 QERLPDQEMGDG-----------------KGLDMARRCSVTSVESTV----------SSGTQTAI 637

  Fly   633 TS--EQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMI 695
            ..  ||...:||:|.::..|.|.||::|::|||:|||.|:|.|.::  .:|.||.:...||...:
Mouse   638 QDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVE--DIAQFLHQEERLDSTQV 700

  Fly   696 GEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHK--Q 758
            ||::......:.:::..:||..||.......|||.:||.|||||||..|..::|.|:..:.:  |
Mouse   701 GEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQ 765

  Fly   759 NQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFN 823
            .|..||:.|.|:.|||:||||..|.|:...|.   .||.|.:.|..||:|..:|..:|.|:.:::
Mouse   766 GQTLFASADTAYVLAYSIIMLTTDLHSPQVKN---KMTKEQYIKMNRGINDSKDLPEEYLSSIYD 827

  Fly   824 AIKNEEIVM-----------------PAEQTGLVRENYQWKVLLRRGD-------------THDG 858
            .|:.::|.|                 .:|:...:..|.:.:.:.:...             |...
Mouse   828 EIEGKKIAMKETKEHTIATKSTKQSVASEKQRRLLYNVEMEQMAKTAKALMEAVSHAKAPFTSAT 892

  Fly   859 HFHYVHDASYDVEIFNIVWGASLSALSFMFDKSTETGY-QRTLAGFSKSAAISAHYNLHSDFDAL 922
            |..:|.      .:|.:||...|:|.|.......:|.. ...|.|...:..|:..:.:..:.||.
Mouse   893 HLDHVR------PMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAY 951

  Fly   923 VLTLCKFTTLLSSVEQHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILD 987
            |..|.:|:.|.:|....|....|.:|               ::|:..:.|..|:.|..||..||.
Mouse   952 VQALARFSLLTASSSITEMKQKNIDT---------------IKTLITVAHTDGNYLGNSWHEILK 1001

  Fly   988 LYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEKPREKQESGLFSSLYSFISSEGQREPTYEEQD 1052
            ...||           |:........|...:....||::.|....||..              ::
Mouse  1002 CISQL-----------ELAQLIGTGVKTRYLSGSGREREGSLKGHSLAG--------------EE 1041

  Fly  1053 FIKLGRKCIKECQLDQMLQESKFVQLESLQELLKCVLALLKAPQGHKSIGLPYAEDQTVFWMEFL 1117
            |:.||...:....:|:.       |:.|.||                |:|            |..
Mouse  1042 FMGLGLGNLVSGGVDKR-------QMASFQE----------------SVG------------ETS 1071

  Fly  1118 VKIVVHNRDRMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLAIYLMRNEELCPIVLQS 1182
            .:.||...||:.                   .|...|....||..::.         ||.:   |
Mouse  1072 SQSVVVAVDRIF-------------------TGSTRLDGNAIVDFVRW---------LCAV---S 1105

  Fly  1183 LKMLLMLKPALLLRISKQISIGIYELLKTSAQNIHSEQDWQII---FNLLECVGAGAVPPNYDDA 1244
            :..|.......:..:.|.:.|..|.:.:...|   ..:.|.:|   ||.:.|      .||.|.|
Mouse  1106 MDELASPHHPRMFSLQKIVEISYYNMNRIRLQ---WSRIWHVIGDHFNKVGC------NPNEDVA 1161

  Fly  1245 QLPLPPNGSAKSDGAISGEEDATAVPERGYTSDSEITKASAAPAVSSPSAENWILVNNKDSELTT 1309
            ...:.           |..:.:....|:|..::....|....|.       ..|:..|:      
Mouse  1162 IFAVD-----------SLRQLSMKFLEKGELANFRFQKDFLRPF-------EHIMKKNR------ 1202

  Fly  1310 ASRPQSPPSLSAPPVNTLVYNC--QLLDHAPFALFKCWDS------------------LAFIVRS 1354
                       :|.:..:|..|  |::......:...|.:                  |||  ::
Mouse  1203 -----------SPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAF--QT 1254

  Fly  1355 VAHITPY-----------NFEACVRCIRIFVEACR----DGGIRQRRKLESAAKQKSSKKRSERK 1404
            ..||...           :|:..|:|:..|  ||.    |..:...|.:....|..|      .:
Mouse  1255 TGHIVSTIFQHHFPAAIDSFQDAVKCLSEF--ACNAAFPDTSMEAIRLIRFCGKYVS------ER 1311

  Fly  1405 PGMASSASSSNLTLLTGDPSDNQINGNAAEQEDLAQRYEQLSIQLLDLMYTLYTRTAQIFRWWAE 1469
            |.:....:|.::.:..||                                               
Mouse  1312 PRVLQEYTSDDMNVAPGD----------------------------------------------- 1329

  Fly  1470 EGCTVPQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQRALLVHDLQTLSGTEWCSCFH 1534
                     .:|..||.|:|..::.:....:.:|||..::.:.:   ::..........|.....
Mouse  1330 ---------RVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFE---IMKSYGHTFAKHWWQDLF 1382

  Fly  1535 QVLFPLLNEL-LPESNAAGQLDAALLEESRIRTAT------IMSKVFLQHLTTLIELGNAFNELW 1592
            :::|.:.:.: |||..:         |:|...|.|      .:..||.|....|.|:      |.
Mouse  1383 RIVFRIFDNMKLPEQQS---------EKSEWMTTTCNHALYAICDVFTQFYEALHEV------LL 1432

  Fly  1593 LDILDYIERFMKVGSDTLSEQMQEILKNMLLVMHSVRVFHNQDGSLQQALWE------------- 1644
            .|:...::..:|..::.|:......|:|:::         :.......|:|:             
Mouse  1433 SDVFAQLQWCVKQDNEQLARSGTNCLENLVI---------SNGEKFSPAVWDETCNCMLDIFKTT 1488

  Fly  1645 -----LTWRRIGEFLPNLKEE-----------------LFHDEGKRAQT-LTNPAPQAAVAA--A 1684
                 ||||..|     ::||                 :..:..:|.|: |:||...:...|  |
Mouse  1489 IPHVLLTWRPAG-----MEEEVSDRHLDVDLDRQSLSSIDRNASERGQSQLSNPTDDSWKGAPYA 1548

  Fly  1685 PQQQLPAVTI 1694
            .|:.|.::.|
Mouse  1549 HQKLLASLLI 1558

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
garzNP_610761.2 COG5307 346..>1062 CDD:227623 184/780 (24%)
Sec7_N 370..512 CDD:289549 36/153 (24%)
Sec7 643..830 CDD:279680 68/188 (36%)
Arfgef2NP_001078964.1 DCB, DCB:DCB domain and DCB:HUS domain interaction. /evidence=ECO:0000250 2..224 37/179 (21%)
PLN03076 11..1718 CDD:215560 357/1830 (20%)
DCB 28..198 CDD:292830 34/153 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..294 16/88 (18%)
Sec7_N 377..531 CDD:289549 36/154 (23%)
HUS, DCB:HUS domain interaction. /evidence=ECO:0000250 515..535 8/19 (42%)
Sec7 650..834 CDD:279680 68/188 (36%)
DUF1981 1174..1255 CDD:286414 14/106 (13%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838950
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5307
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D815698at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.750

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