DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment garz and CYTH2

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_006723535.1	Gene:	CYTH2 / 9266	HGNCID:	9502	Length:	421	Species:	Homo sapiens

Alignment Length:	269	Identity:	90/269 - (33%)
Similarity:	149/269 - (55%)	Gaps:	16/269 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   575 APATGGSRHSRHNSGLEGIVIDSGNSVAAEEK--VENI---ASFINASSHRLR---LQSGGEGVG 631
            :|||.....| .|.||.  .:.....:..||:  :|||   ...:.....|||   .::..|..|
Human    10 SPATSPVMES-ENQGLS--PLPKPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEG 71

  Fly   632 ITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIG 696
            :.:.:.:|..|:.|.::.|.::||..|:||||:|.|:.:|  :..|.::|.||.:..||:|..||
Human    72 LEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELL--QNTPEEIARFLYKGEGLNKTAIG 134

  Fly   697 EYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQD 761
            :|:.:::.::..:|..|||..:||.|.:.||||.:|.:|||||||..|..::|.|:..:...|..
Human   135 DYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPG 199

  Fly   762 PFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIK 826
            .|.:.|..:.|::|:||||...||.|.:  :.| .||.|....||:|.|.|..:|:|..::::|:
Human   200 VFQSTDTCYVLSFAVIMLNTSLHNPNVR--DKP-GLERFVAMNRGINEGGDLPEELLRNLYDSIR 261

  Fly   827 NEEIVMPAE 835
            ||...:|.:
Human   262 NEPFKIPED 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	90/269 (33%)
		Sec7_N	370..512	CDD:289549
		Sec7	643..830	CDD:279680	70/186 (38%)
CYTH2	XP_006723535.1	Sec7	83..265	CDD:396096	70/186 (38%)
CYTH2	XP_006723535.1	PH_GRP1-like	280..399	CDD:269954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148852
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740