DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment garz and CYTH3

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_004218.1	Gene:	CYTH3 / 9265	HGNCID:	9504	Length:	399	Species:	Homo sapiens

Alignment Length:	204	Identity:	76/204 - (37%)
Similarity:	122/204 - (59%)	Gaps:	5/204 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   632 ITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIG 696
            :||.:.:|..|:.:.::.|.::||..|:||||:|.|:.:|.:  .|..||.||.:..||:|.:||
Human    55 LTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQS--SPEDVAQFLYKGEGLNKTVIG 117

  Fly   697 EYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQD 761
            :|:.::...:.|:|..||:..:|..|.:.||||.:|.:|||||||..|..::|.|:..:...|..
Human   118 DYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPG 182

  Fly   762 PFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIK 826
            .|.:.|..:.|::||||||...||.|.:  :.| |.|.|....||:|.|.|..:|:|..::.:||
Human   183 VFQSTDTCYVLSFAIIMLNTSLHNHNVR--DKP-TAERFIAMNRGINEGGDLPEELLRNLYESIK 244

  Fly   827 NEEIVMPAE 835
            ||...:|.:
Human   245 NEPFKIPED 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	76/204 (37%)
		Sec7_N	370..512	CDD:289549
		Sec7	643..830	CDD:279680	71/186 (38%)
CYTH3	NP_004218.1	Sec7	66..248	CDD:396096	71/186 (38%)
		PH_GRP1-like	263..382	CDD:269954
		C-terminal autoinhibitory region. /evidence=ECO:0000269\|PubMed:23940353	391..399
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148857
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740