|
Fly 8 IYVVRGEMATLMTAMRRGTRWNATAYVDDENDSLLKLFIDLKHELNRIEDLRQIEPQVFLAPFLE 72
||:::||:..::.|::|..||:....:|:|.|.||..|..||..||.|.:|.:|||.|||.||||
Human 6 IYIIQGEINIVVGAIKRNARWSTHTPLDEERDPLLHSFGHLKEVLNSITELSEIEPNVFLRPFLE 70
Fly 73 VIRTADATGPLTSLALASVNKLLSYGLIDPTSPNLADIVERIADAVTHARFMGTDQSSDGVTFMR 137
|||:.|.|||:|.|||.||||.|||.|||||....|:.:|.:|||||||||:|||.:||.|..|:
Human 71 VIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMADAVTHARFVGTDPASDEVVLMK 135
Fly 138 VIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMRLPQFA 202
:::||.||:.:|.||.::|.|:||:|.|||:|.||.|||||||:|||.:|.|||.|.|.|||||.
Human 136 ILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFK 200
Fly 203 EER-----------SDTMLQK-RFTIGDAASGATQ-------EKLKRKTVA----------QAQT 238
||. |..:|.| ..:.|:......| :.||.|..| :.:.
Human 201 EEPKNYVGTNMKKISPCLLNKLELSSGEQTKALNQLERVLLFKNLKLKMRAGGMSDSSKWKKQKR 265
Fly 239 APR---------KSSAVEEPPQTPQSANLT-------VPGHL-----KAPILATTPASPAG---- 278
:|| ..|.:..|..|..|:||| ||..: :|.....:|::.:|
Human 266 SPRPPRHMTKVTPGSELPTPNGTTLSSNLTGGMPFIDVPTPISSASSEAASAVVSPSTDSGLEFS 330
Fly 279 -------NILDMQGKITQTPTTTASTGEDETTVPETPVIQVEST----------ESEP-LLDGET 325
::.|::...:...:|....|..|..|||.|.:|.|.| ||.| :|:..|
Human 331 SQTTSKEDLTDLEQPGSPGYSTATEPGSSELGVPEQPDLQQEGTHVEKSQSASVESIPEVLEECT 395
Fly 326 GEAT-STLAEANSSEYINSVGVRFTQQSTDHDVTSLSPYGLPFIQELFRFLIILCNPLDKQNSDS 389
..|. |..|..:..:|:|..||||| ||:..:.|:|.|||||.|:|||||||.|.||.|:.||:.
Human 396 SPADHSDSASVHDMDYVNPRGVRFT-QSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRHNSEV 459
Fly 390 MMHTGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLR 454
|:|.||.|||||.|.|. :.:.:.||.|:||::||:|..|||.|||:::||.|::|||||||:|
Human 460 MIHMGLHLLTVALESAP--VAQCQTLLGLIKDEMCRHLFQLLSIERLNLYAASLRVCFLLFESMR 522
Fly 455 GHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFE 519
.|||||:|.|::||.|||..:|||.||||:|:||:.::||||||.||||||||||||.||:::||
Human 523 EHLKFQMEMYIKKLMEIITVENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFE 587
Fly 520 SLTNLLSKYTLSATNAVYSTHIISMDTLLSVIDSIERNCAAS-KNSSNNRESLPEAAPA---TGG 580
.||.||||.....:..:|:||::|:|.||:||||.|.:|.|. .||...:|....|.|: ..|
Human 588 ELTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNSLTQQEKKETARPSCEIVDG 652
Fly 581 SRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINA----SSHRLRLQSGGEGVGITSE------ 635
:|.:.:. ...|::.|...:||.|.. ...||..:.|..|.....|
Human 653 TREASNT-----------ERTASDGKAVGMASDIPGLHLPGGGRLPPEHGKSGCSDLEEAVDSGA 706
Fly 636 -------------------QLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVA 681
:|.::|.||:||..|||:|||:|:||||:|||.|:|...:|..:||
Human 707 DKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVA 771
Fly 682 LFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFL 746
.:|||||.||||||||::|.:||:| :|.:||.:|.|.|||:|:|||||||.||||||||:|..
Human 772 QWLRENPRLDKKMIGEFVSDRKNID--LLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQR 834
Fly 747 VLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGE 811
:||.|::.|...|..||||.||.|.||||:||||.||||.|.::.|.|||||:|.|||:|:|||:
Human 835 LLEAFTERWMNCNGSPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGK 899
Fly 812 DFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFNIV 876
||:|::|..:::||||||||||.||||||||||.|.|||.||.|.:|.|..|..||||:::|.:.
Human 900 DFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWNVLLHRGATPEGIFLRVPTASYDLDLFTMT 964
Fly 877 WGASLSALSFMFDKS-TETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHE 940
||.:::|||::|||| .||..|:.::||.|.|.|||||.|...||.|:::|||||.|.|...::.
Human 965 WGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENL 1029
Fly 941 PAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIEV 1005
|:. ||.|.||..|.:|||.|.|.:||.|||.||:|::..|||||.:||||::|||
Human 1030 PSV----------FGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMIEV 1084
Fly 1006 EDFCEANGKAMLILEK-PREKQESGLFSSLYSFIS--------SEGQREPTYEEQDFIKLGRKCI 1061
|||.:.|||..|..|: |..:.| |::.||:| ....|.|:.|.|:..::..:||
Human 1085 EDFVDPNGKISLQREETPSNRGE----STVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALECI 1145
Fly 1062 KECQLDQMLQESKFVQLESLQELLKCVLALLKAPQGHKSIGLPYAEDQTVFWMEFLVKIVVHNRD 1126
|:|..::|:.||||:||||||||:|.::::....: .|.|:...|.:|.|::||:.|||
Human 1146 KQCDPEKMITESKFLQLESLQELMKALVSVTPDEE-------TYDEEDAAFCLEMLLRIVLENRD 1203
Fly 1127 RMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLAIYLMRNEELCPIVLQSLKMLLMLKP 1191
|:..:|..|||.:|.|.:.:.. :.:|:.|.:|.:|:|||.|:|.||:...||.||::||::||
Human 1204 RVGCVWQTVRDHLYHLCVQAQD--FCFLVERAVVGLLRLAIRLLRREEISAQVLLSLRILLLMKP 1266
Fly 1192 ALLLRISKQISIGIYELLKTSAQNIHSEQDWQIIFNLLECVGAGAVPPNYDDAQLPLPPNGSAKS 1256
::|.|:|.|::.|::|||||:|.||||..||..:|.||||:|:|..|| |.| ..:|::
Human 1267 SVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIGSGVKPP----AAL----QATARA 1323
Fly 1257 DGAISGEEDATAVP---------ERGYTSDSEITKASAAPAVSSPSA-------ENWILVNNKDS 1305
|...:|.:..:.:| :||||||||:......|.....|| ..|::|...|.
Human 1324 DAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKIHRSATDADVVNSGWLVVGKDDV 1388
Fly 1306 ELTTASRPQSPPSLSAPPVNTLVYNCQL---LDHAPF---ALFKCWDSLAFIVRSVAHITPYNFE 1364
: .|.|..|.|..:.|:....| ||..|. :|.||.:||:||||..|||||.|||
Human 1389 D-------NSKPGPSRPGPSPLINQYSLTVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFE 1446
Fly 1365 ACVRCIRIFVEACRDGGIRQRRKLESAAKQKSS----KKRSE-----RKPGMASSASSSNLTLLT 1420
.||:.:||||||..:||.:.:.|...:.|..|. ||:|: |:|..:|..:| .
Human 1447 LCVKTLRIFVEASLNGGCKSQEKRGKSHKYDSKGNRFKKKSKEGSMLRRPRTSSQHAS------R 1505
Fly 1421 GDPSDNQINGNAAEQEDLAQRYEQLSIQ----LLDLMYTLYTRTAQIFRWWAEE-------GCTV 1474
|..||:. |.|.:...|..:|:| |||||:||:||.|.|:..|||| |..:
Human 1506 GGQSDDD------EDEGVPASYHTVSLQVSQDLLDLMHTLHTRAASIYSSWAEEQRHLETGGQKI 1564
Fly 1475 -PQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQRALLVHDLQTLSGTEWCSCFHQVLF 1538
..|..||:..|||||||||.|..|.||:||..|::.| ||||||||||.|...||.|||::|||
Human 1565 EADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYL-QRALLVHDLQKLDALEWESCFNKVLF 1628
Fly 1539 PLLNELLPESNAAGQLDAALLEESRIRTATIMSKVFLQHLTTLIELGNAFNELWLDILDYIERFM 1603
|||.:||...:.| |...:||:|:|.:|::||||||||:.|:.| :.|..|||.|||:::::|
Human 1629 PLLTKLLENISPA---DVGGMEETRMRASTLLSKVFLQHLSPLLSL-STFAALWLTILDFMDKYM 1689
Fly 1604 KVG-SDTLSEQMQEILKNMLLVMHSVRVFHNQD--GSLQQALWELTWRRIGEFLPNLKEELFHDE 1665
..| ||.|||.:.|.||||||||.:..:||:.| |....||||:||.||..|||:|::|||
Human 1690 HAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSALWEITWERIDCFLPHLRDELF--- 1751
Fly 1666 GKRAQTLTNPAPQAAVAAAPQQQLPAVTILPRQTQVSNELVVSA--------PTPPAATPLLGS- 1721
:...:.:|.|. .||.|.|. .|..|..:| |.||.....||:
Human 1752 --KQTVIQDPMPM-----EPQGQKPL---------ASAHLTSAAGDTRTPGHPPPPEIPSELGAC 1800
Fly 1722 ---PVESPRRSIILQP--PMADVLQQPPSFVFAQPIIVPP--QPPAVTDP--------IPPSTLL 1771
..||||.:....| |:| ..||.:...|...|| |||.:..| :||.| |
Human 1801 DFEKPESPRAASSSSPGSPVA----SSPSRLSPTPDGPPPLAQPPLILQPLASPLQVGVPPMT-L 1860
Fly 1772 PDLVN----EATAAAVQATTTSPT 1791
|.::| |||:......|..||
Human 1861 PIILNPALIEATSPVPLLATPRPT 1884
| 
