DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment garz and GBF1

DIOPT Version :9

Sequence 1:NP_610761.2 Gene:garz / 36337 FlyBaseID:FBgn0264560 Length:1983 Species:Drosophila melanogaster
Sequence 2:XP_006718110.1 Gene:GBF1 / 8729 HGNCID:4181 Length:1893 Species:Homo sapiens


Alignment Length:1970 Identity:842/1970 - (42%)
Similarity:1151/1970 - (58%) Gaps:277/1970 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 IYVVRGEMATLMTAMRRGTRWNATAYVDDENDSLLKLFIDLKHELNRIEDLRQIEPQVFLAPFLE 72
            ||:::||:..::.|::|..||:....:|:|.|.||..|..||..||.|.:|.:|||.|||.||||
Human     6 IYIIQGEINIVVGAIKRNARWSTHTPLDEERDPLLHSFGHLKEVLNSITELSEIEPNVFLRPFLE 70

  Fly    73 VIRTADATGPLTSLALASVNKLLSYGLIDPTSPNLADIVERIADAVTHARFMGTDQSSDGVTFMR 137
            |||:.|.|||:|.|||.||||.|||.|||||....|:.:|.:|||||||||:|||.:||.|..|:
Human    71 VIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMADAVTHARFVGTDPASDEVVLMK 135

  Fly   138 VIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMRLPQFA 202
            :::||.||:.:|.||.::|.|:||:|.|||:|.||.|||||||:|||.:|.|||.|.|.|||||.
Human   136 ILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFK 200

  Fly   203 EER-----------SDTMLQK-RFTIGDAASGATQ-------EKLKRKTVA----------QAQT 238
            ||.           |..:|.| ..:.|:......|       :.||.|..|          :.:.
Human   201 EEPKNYVGTNMKKISPCLLNKLELSSGEQTKALNQLERVLLFKNLKLKMRAGGMSDSSKWKKQKR 265

  Fly   239 APR---------KSSAVEEPPQTPQSANLT-------VPGHL-----KAPILATTPASPAG---- 278
            :||         ..|.:..|..|..|:|||       ||..:     :|.....:|::.:|    
Human   266 SPRPPRHMTKVTPGSELPTPNGTTLSSNLTGGMPFIDVPTPISSASSEAASAVVSPSTDSGLEFS 330

  Fly   279 -------NILDMQGKITQTPTTTASTGEDETTVPETPVIQVEST----------ESEP-LLDGET 325
                   ::.|::...:...:|....|..|..|||.|.:|.|.|          ||.| :|:..|
Human   331 SQTTSKEDLTDLEQPGSPGYSTATEPGSSELGVPEQPDLQQEGTHVEKSQSASVESIPEVLEECT 395

  Fly   326 GEAT-STLAEANSSEYINSVGVRFTQQSTDHDVTSLSPYGLPFIQELFRFLIILCNPLDKQNSDS 389
            ..|. |..|..:..:|:|..||||| ||:..:.|:|.|||||.|:|||||||.|.||.|:.||:.
Human   396 SPADHSDSASVHDMDYVNPRGVRFT-QSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRHNSEV 459

  Fly   390 MMHTGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLR 454
            |:|.||.|||||.|.|.  :.:.:.||.|:||::||:|..|||.|||:::||.|::|||||||:|
Human   460 MIHMGLHLLTVALESAP--VAQCQTLLGLIKDEMCRHLFQLLSIERLNLYAASLRVCFLLFESMR 522

  Fly   455 GHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFE 519
            .|||||:|.|::||.|||..:|||.||||:|:||:.::||||||.||||||||||||.||:::||
Human   523 EHLKFQMEMYIKKLMEIITVENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFE 587

  Fly   520 SLTNLLSKYTLSATNAVYSTHIISMDTLLSVIDSIERNCAAS-KNSSNNRESLPEAAPA---TGG 580
            .||.||||.....:..:|:||::|:|.||:||||.|.:|.|. .||...:|....|.|:   ..|
Human   588 ELTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNSLTQQEKKETARPSCEIVDG 652

  Fly   581 SRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINA----SSHRLRLQSGGEGVGITSE------ 635
            :|.:.:.           ...|::.|...:||.|..    ...||..:.|..|.....|      
Human   653 TREASNT-----------ERTASDGKAVGMASDIPGLHLPGGGRLPPEHGKSGCSDLEEAVDSGA 706

  Fly   636 -------------------QLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVA 681
                               :|.::|.||:||..|||:|||:|:||||:|||.|:|...:|..:||
Human   707 DKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVA 771

  Fly   682 LFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFL 746
            .:|||||.||||||||::|.:||:|  :|.:||.:|.|.|||:|:|||||||.||||||||:|..
Human   772 QWLRENPRLDKKMIGEFVSDRKNID--LLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQR 834

  Fly   747 VLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGE 811
            :||.|::.|...|..||||.||.|.||||:||||.||||.|.::.|.|||||:|.|||:|:|||:
Human   835 LLEAFTERWMNCNGSPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGK 899

  Fly   812 DFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFNIV 876
            ||:|::|..:::||||||||||.||||||||||.|.|||.||.|.:|.|..|..||||:::|.:.
Human   900 DFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWNVLLHRGATPEGIFLRVPTASYDLDLFTMT 964

  Fly   877 WGASLSALSFMFDKS-TETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHE 940
            ||.:::|||::|||| .||..|:.::||.|.|.|||||.|...||.|:::|||||.|.|...::.
Human   965 WGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENL 1029

  Fly   941 PAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIEV 1005
            |:.          ||.|.||..|.:|||.|.|.:||.|||.||:|::..|||||.:||||::|||
Human  1030 PSV----------FGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMIEV 1084

  Fly  1006 EDFCEANGKAMLILEK-PREKQESGLFSSLYSFIS--------SEGQREPTYEEQDFIKLGRKCI 1061
            |||.:.|||..|..|: |..:.|    |::.||:|        ....|.|:.|.|:..::..:||
Human  1085 EDFVDPNGKISLQREETPSNRGE----STVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALECI 1145

  Fly  1062 KECQLDQMLQESKFVQLESLQELLKCVLALLKAPQGHKSIGLPYAEDQTVFWMEFLVKIVVHNRD 1126
            |:|..::|:.||||:||||||||:|.::::....:       .|.|:...|.:|.|::||:.|||
Human  1146 KQCDPEKMITESKFLQLESLQELMKALVSVTPDEE-------TYDEEDAAFCLEMLLRIVLENRD 1203

  Fly  1127 RMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLAIYLMRNEELCPIVLQSLKMLLMLKP 1191
            |:..:|..|||.:|.|.:.:..  :.:|:.|.:|.:|:|||.|:|.||:...||.||::||::||
Human  1204 RVGCVWQTVRDHLYHLCVQAQD--FCFLVERAVVGLLRLAIRLLRREEISAQVLLSLRILLLMKP 1266

  Fly  1192 ALLLRISKQISIGIYELLKTSAQNIHSEQDWQIIFNLLECVGAGAVPPNYDDAQLPLPPNGSAKS 1256
            ::|.|:|.|::.|::|||||:|.||||..||..:|.||||:|:|..||    |.|    ..:|::
Human  1267 SVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIGSGVKPP----AAL----QATARA 1323

  Fly  1257 DGAISGEEDATAVP---------ERGYTSDSEITKASAAPAVSSPSA-------ENWILVNNKDS 1305
            |...:|.:..:.:|         :||||||||:......|.....||       ..|::|...|.
Human  1324 DAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKIHRSATDADVVNSGWLVVGKDDV 1388

  Fly  1306 ELTTASRPQSPPSLSAPPVNTLVYNCQL---LDHAPF---ALFKCWDSLAFIVRSVAHITPYNFE 1364
            :       .|.|..|.|..:.|:....|   ||..|.   :|.||.:||:||||..|||||.|||
Human  1389 D-------NSKPGPSRPGPSPLINQYSLTVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFE 1446

  Fly  1365 ACVRCIRIFVEACRDGGIRQRRKLESAAKQKSS----KKRSE-----RKPGMASSASSSNLTLLT 1420
            .||:.:||||||..:||.:.:.|...:.|..|.    ||:|:     |:|..:|..:|      .
Human  1447 LCVKTLRIFVEASLNGGCKSQEKRGKSHKYDSKGNRFKKKSKEGSMLRRPRTSSQHAS------R 1505

  Fly  1421 GDPSDNQINGNAAEQEDLAQRYEQLSIQ----LLDLMYTLYTRTAQIFRWWAEE-------GCTV 1474
            |..||:.      |.|.:...|..:|:|    |||||:||:||.|.|:..||||       |..:
Human  1506 GGQSDDD------EDEGVPASYHTVSLQVSQDLLDLMHTLHTRAASIYSSWAEEQRHLETGGQKI 1564

  Fly  1475 -PQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQRALLVHDLQTLSGTEWCSCFHQVLF 1538
             ..|..||:..|||||||||.|..|.||:||..|::.| ||||||||||.|...||.|||::|||
Human  1565 EADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYL-QRALLVHDLQKLDALEWESCFNKVLF 1628

  Fly  1539 PLLNELLPESNAAGQLDAALLEESRIRTATIMSKVFLQHLTTLIELGNAFNELWLDILDYIERFM 1603
            |||.:||...:.|   |...:||:|:|.:|::||||||||:.|:.| :.|..|||.|||:::::|
Human  1629 PLLTKLLENISPA---DVGGMEETRMRASTLLSKVFLQHLSPLLSL-STFAALWLTILDFMDKYM 1689

  Fly  1604 KVG-SDTLSEQMQEILKNMLLVMHSVRVFHNQD--GSLQQALWELTWRRIGEFLPNLKEELFHDE 1665
            ..| ||.|||.:.|.||||||||.:..:||:.|  |....||||:||.||..|||:|::|||   
Human  1690 HAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSALWEITWERIDCFLPHLRDELF--- 1751

  Fly  1666 GKRAQTLTNPAPQAAVAAAPQQQLPA----VTILPRQTQVSNELVVSAPTPPAATPLLGS----P 1722
              :...:.:|.|.     .||.|.|.    :|.....|:....     |.||.....||:    .
Human  1752 --KQTVIQDPMPM-----EPQGQKPLASAHLTSAAGDTRTPGH-----PPPPEIPSELGACDFEK 1804

  Fly  1723 VESPRRSIILQP--PMADVLQQPPSFVFAQPIIVPP--QPPAVTDP--------IPPSTLLPDLV 1775
            .||||.:....|  |:|    ..||.:...|...||  |||.:..|        :||.| ||.::
Human  1805 PESPRAASSSSPGSPVA----SSPSRLSPTPDGPPPLAQPPLILQPLASPLQVGVPPMT-LPIIL 1864

  Fly  1776 N----EATAAAVQATTTSPT 1791
            |    |||:......|..||
Human  1865 NPALIEATSPVPLLATPRPT 1884

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
garzNP_610761.2 COG5307 346..>1062 CDD:227623 372/758 (49%)
Sec7_N 370..512 CDD:289549 88/141 (62%)
Sec7 643..830 CDD:279680 113/186 (61%)
GBF1XP_006718110.1 Sec7_N 434..579 CDD:289549 91/146 (62%)
Sec7 733..918 CDD:279680 113/186 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148866
Domainoid 1 1.000 637 1.000 Domainoid score I168
eggNOG 1 0.900 - - E1_COG5307
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37897
Inparanoid 1 1.050 1346 1.000 Inparanoid score I144
Isobase 1 0.950 - 0 Normalized mean entropy S3208
OMA 1 1.010 - - QHG55524
OrthoDB 1 1.010 - - D49474at33208
OrthoFinder 1 1.000 - - FOG0003083
OrthoInspector 1 1.000 - - oto90706
orthoMCL 1 0.900 - - OOG6_102130
Panther 1 1.100 - - LDO PTHR10663
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2128
SonicParanoid 1 1.000 - - X2055
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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