Protein Alignment garz and GEA2

DIOPT Version :9

• Sequence 1: NP_610761.2
• Gene: garz / 36337
• FlyBaseID: FBgn0264560
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_010892.1
• Gene: GEA2 / 856691
• SGDID: S000000748
• Length: 1459
• Species: Saccharomyces cerevisiae
• Alignment Length: 1757
• Identity: 387/1757 - (22%)
• Similarity: 677/1757 - (38%)
• Gaps: 509/1757 - (28%)

  Fly     8 IYVVRGEMATLMTAMRRGTRWNATAYV--------------DD-------------ENDSLLKLF 45
            :.::..|...|.||||:.:::.:.:.|              ||             .||..|..|
Yeast    12 VTIIIKECINLSTAMRKYSKFTSQSGVAALLGGGSEIFSNQDDYLAHTFNNLNTNKHNDPFLSGF 76

  Fly    46 IDLKHELNRIEDLRQIEPQVFLAPFLEVIRTADATGPLTSLALASVNKLLSYGLIDPTSPNLADI 110
            |.|:..||::::|..|:....|.|||.::.|:..:|.:|||||.|:.|..:..:|:.:|.|....
Yeast    77 IQLRLMLNKLKNLDNIDSLTILQPFLLIVSTSSISGYITSLALDSLQKFFTLNIINESSQNYIGA 141

  Fly   111 VERIADAVTHARFMGTDQSSDGVTFMRVIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRL 175
            .....:|:||.||.|:.|.||....::|:.:|.:::.||.|..:||..:.:|:.:...::...|.
Yeast   142 HRATVNALTHCRFEGSQQLSDDSVLLKVVFLLRSIVDSPYGDLLSNSIIYDVLQTILSLACNNRR 206

  Fly   176 SELLRRSAEKSLKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAP 240
            ||:||.:|:.::..:.:..|.:|     :..:.:...:..|.|  ...|.:.||..|:
Yeast   207 SEVLRNAAQSTMIAVTVKIFSKL-----KTIEPVNVNQIYIND--ESYTNDVLKADTI------- 257

  Fly   241 RKSSAVEEPPQTPQSANLTVPGHLKAPILATTPASPAGNILDMQGKITQTPTTTASTGEDETTVP 305
              .:.||...:..|.                   .|.|..::                 :|..:.
Yeast   258 --GTNVESKEEGSQE-------------------DPIGMKVN-----------------NEEAIS 284

  Fly   306 ETPVIQVESTESEPLLDG-ETGEATSTLAEANSSEYINSVGVRFTQQSTDHDVTSLSPYGLPFIQ 369
            |...|:.|...||...:| |..:.......:||         |....:.|:       ||||.::
Yeast   285 EDDGIEEEHIHSEKSTNGAEQLDIVQKTTRSNS---------RIQAYADDN-------YGLPVVR 333

  Fly   370 ELFRFLIILCNPLDK-QNSDSMMHTGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLL-S 432
            :....|:.|..|.:: ::|.|....||.|:..|.|::.|.:..|..|..|:.|.:.::::.:: :
Yeast   334 QYLNLLLSLIAPENELKHSYSTRIFGLELIQTALEISGDRLQLYPRLFTLISDPIFKSILFIIQN 398

  Fly   433 SERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEII---------ASDNPKTPYEMRELAL 488
            :.:||:..|.|||...|...|..:|:.|:|..|.::..|:         :|:|...|..::||.:
Yeast   399 TTKLSLLQATLQLFTTLVVILGNNLQLQIELTLTRIFSILLDDGTANNSSSENKNKPSIIKELLI 463

  Fly   489 DNLLQLW-RIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTL--SATNAVYSTHIISMDTLLSV 550
            :.:..|| |.|.|.|..:||:||:|...|:..:....|:|..|  ||.....|...|.::.|:|:
Yeast   464 EQISILWTRSPSFFTSTFINFDCNLDRADVSINFLKALTKLALPESALTTTESVPPICLEGLVSL 528

  Fly   551 IDSIERNCAASKNSSNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEE--KVENIASF 613
            :|.                                        :.|....:..||  :.:|
Yeast   529 VDD----------------------------------------MFDHMKDIDREEFGRQKN---- 549

  Fly   614 INASSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPM 678
                                ..::.|.:.:|....:.|..||::|:|||..|.|.|.:.::.| .
Yeast   550 --------------------EMEILKKRDRKTEFIECTNAFNEKPKKGIPMLIEKGFIASDSD-K 593

  Fly   679 QVALFL-RENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAP 742
            .:|.|| ..|..::||.||..:.....|  .:|..::..|||:|||||:|:|:.|..||||||:.
Yeast   594 DIAEFLFNNNNRMNKKTIGLLLCHPDKV--SLLNEYIRLFDFSGLRVDEAIRILLTKFRLPGESQ 656

  Fly   743 LIFLVLEHFSD-HWHKQNQDPF--------------ANVDAAFRLAYAIIMLNMDQHNSNAKRLN 792
            .|..::|.||. :...|:.||.              .:.|:.|.|:|:|||||.|.||...|.
Yeast   657 QIERIIEAFSSAYCENQDYDPSKISDNAEDDISTVQPDADSVFILSYSIIMLNTDLHNPQVKE-- 719

  Fly   793 VPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENY---QWKVLLR--- 851
             .|:.||::.||:|....:||....|.:::.:|:::|||||.|..|  .|.:   .|..|:.
Yeast   720 -HMSFEDYSGNLKGCCNHKDFPFWYLDRIYCSIRDKEIVMPEEHHG--NEKWFEDAWNNLISSTT 781

  Fly   852 -----RGDTHDGHFHYVHD-------ASYDVEIFNIVWGASLSALSFMF----DKSTETGYQRTL 900
                 :.||..     |.|       .::|..||..|..:.:|.|..::    |....|   |.:
Yeast   782 VITEIKKDTQS-----VMDKLTPLELLNFDRAIFKQVGPSIVSTLFNIYVVASDDHIST---RMI 838

  Fly   901 AGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHE---------PAP--------ANNE- 947
            ....|.:.|||.::....|:.::.::.|.|||::|....|         |.|        .|.|
Yeast   839 TSLDKCSYISAFFDFKDLFNDILNSIAKGTTLINSSHDDELSTLAFEYGPMPLVQIKFEDTNTEI 903

  Fly   948 --TQQAVNFGLNGKAQAAMRTVFLLVHDYGD---CLRESWKHILDLYLQLF-------------- 993
              :..||.||.:.|.|......|.::....|   ..:|.|.:|:::.|.|:
Yeast   904 PVSTDAVRFGRSFKGQLNTVVFFRIIRRNKDPKIFSKELWLNIVNIILTLYEDLILSPDIFPDLQ 968

  Fly   994 -RLKL--LPKSLIEVEDFCEANGKAMLILEKPREKQESGLFSSLYSFISSEGQREPTYEEQDFIK 1055
             ||||  |||...|:    ..|          :.|:..||.|:..|::  :|..|||.||....|
Yeast   969 KRLKLSNLPKPSPEI----SIN----------KSKESKGLLSTFASYL--KGDEEPTEEEIKSSK 1017

  Fly  1056 LGRKCIKECQLDQML--QESKFVQLESLQELLKCVLALLKAPQGHKSIGLPYAEDQTVFWMEFLV 1118
            ...:|||...:...:  .||...     .:|:|.:|...|..:  .:....|.|.:.:|.:|..:
Yeast  1018 KAMECIKSSNIAASVFGNESNIT-----ADLIKTLLDSAKTEK--NADNSRYFEAELLFIIELTI 1075

  Fly  1119 KIVVHNRDRMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLAIYLMRNEELCPIVLQSL 1183
            .:.:..::.. .|...:..:::.|   |.:.|   |..|.:..:|...|.|:   .||....:.|
Yeast  1076 ALFLFCKEEK-ELGKFILQKVFQL---SHTKG---LTKRTVRRMLTYKILLI---SLCADQTEYL 1130

  Fly  1184 KMLL---MLKPALLLRISKQISIGIYELLKTSAQNIHSEQDWQIIFNLLECVGAGAVPPNYDDAQ 1245
            ..|:   :||.            |.....|..|.| ..::..:.:|:|.|
Yeast  1131 SKLINDELLKK------------GDIFTQKFFATN-QGKEFLKRLFSLTE--------------- 1167

  Fly  1246 LPLPPNGSAKSDGAISGEED-------ATAVPERG-----YTSDSEITKASAAPAVSSPSAEN-- 1296
                   |....|.:.|.|:       .||:.|:.     |.::|..|.::..      :.||
Yeast  1168 -------SEFYRGFLLGNENFWKFLRKVTAMKEQSESIFEYLNESIKTDSNIL------TNENFM 1219

  Fly  1297 WILVNNKDSELTTASRPQSPPSLSAPPVNTLVYNCQLLDHAPFALFKCWDSLAFIVRSVAHITPY 1361
            |:|                                .|||
Yeast  1220 WVL--------------------------------GLLD-------------------------- 1226

  Fly  1362 NFEACVRCIRIFVEACRDGGIRQRRKLESAAKQKSSKKRSERKPGMASSASSSNLTLLTGDPSDN 1426
                         |....|.:....::|       .||.:|
Yeast  1227 -------------EISSMGAVGNHWEIE-------YKKLTE------------------------ 1247

  Fly  1427 QINGNAAEQEDLAQRYEQLSIQLLDLMYTLY-----TRTAQIFRWWAEEGCTVPQSAALWSPGWC 1486
              :|:..::|:..::..:||::.:.|...|.     .|..:||
Yeast  1248 --SGHKIDKENPYKKSIELSLKSIQLTSHLLEDNNDLRKNEIF---------------------- 1288

  Fly  1487 PLLQGIARLAMDRRREVRTHAISCLQQRALLVHDLQTLSGTEWCSCFHQVLFPLLNELLPESNAA 1551
            .::|.:|...::..:::...|:..|:|..:...::.|.............|.||||      ::.
Yeast  1289 AIIQALAHQCINPCKQISEFAVVTLEQTLINKIEIPTNEMESVEELIEGGLLPLLN------SSE 1347

  Fly  1552 GQLDAALLEESRIRTATIMSKVFLQHLTTLIELGNAFNELWLDILDYIERFMKVGSDTLSEQMQE 1616
            .|.|..:|..|.:   ||:|.|:|.:|    :||...||.:|.||....:|:: .|| :.:::|:
Yeast  1348 TQEDQKILISSIL---TIISNVYLHYL----KLGKTSNETFLKILSIFNKFVE-DSD-IEKKLQQ 1403

  Fly  1617 IL 1618
            ::
Yeast  1404 LI 1405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	208/809 (26%)
		Sec7_N	370..512	CDD:289549	43/153 (28%)
		Sec7	643..830	CDD:279680	69/202 (34%)
GEA2	NP_010892.1	COG5307	298..1331	CDD:227623	284/1328 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344270
Domainoid	1	1.000	67	1.000	Domainoid score	I2350
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	289	1.000	Inparanoid score	I533
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55524
OrthoFinder	1	1.000	-	-		FOG0003083
OrthoInspector	1	1.000	-	-		otm46872
orthoMCL	1	0.900	-	-		OOG6_102130
Panther	1	1.100	-	-	O	PTHR10663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2128
SonicParanoid	1	1.000	-	-		X2055
TreeFam	0	0.000	Not matched by this tool.
	13	12.830