DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and SYT1

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_015420.1	Gene:	SYT1 / 856210	SGDID:	S000006299	Length:	1226	Species:	Saccharomyces cerevisiae

Alignment Length:	1360	Identity:	240/1360 - (17%)
Similarity:	426/1360 - (31%)	Gaps:	455/1360 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 PRKS----SAVEEPPQTP-QSANLTVPG--HLK-----APILATTPA---SPAGNILDMQGKITQ 289
            |.||    .::|:.|:.. :...||..|  ::|     ||.:...||   .|:.|.|....:.:|
Yeast   122 PFKSENNIDSIEKVPKPDGERVTLTSSGSDNVKRNSKHAPFIPVKPALEKFPSSNRLSRDYRKSQ 186

  Fly   290 TPTTTASTGEDETTVPETPVIQVESTESEPLLDGETGEATSTLAEANSSEYINSVGVRFTQQSTD 354
            .||..    ..:..||..|.:...||.|      ..|.:|:      :|.|.|. ..|....|:.
Yeast   187 EPTLF----NGDRLVPTLPTVSRISTSS------SVGSSTA------ASRYFNP-SKRAVVASSS 234

  Fly   355 HDVTSLSPYGLPFIQELFRFLIILCNPLDKQNSDSMMHTGLSLLTVAFEVAADNIGKYEGLLELV 419
            ...:|:            :|..:...|||              .|...|:|..
Yeast   235 SSSSSI------------KFNSLHAIPLD--------------ATPQIELAKQ------------ 261

  Fly   420 KDDLCRNLISLLSSERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMR 484
            :|::.:.......|..:.:|                       .|:.| :....:..|.:|
Yeast   262 QDEISKRRFGRRRSRTVDVF-----------------------DYINK-NNTAKNKPPLSP---- 298

  Fly   485 ELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTLSATNAVY--STHIISMDTL 547
                                      ..:...:.|..||.|.:..:.:...:.  ..:|||.||
Yeast   299 --------------------------SSFIRTIDEKNTNSLMQDPMGSRGPLLPDDANIISNDT- 336

  Fly   548 LSVIDSIERNCAASKNSSNNRESLPEAAPATGGSRHSRHNSGLE---GIVIDSGNSVAAEEKVEN 609
                |..|.:....:..|.:|..........||.|.|..:.|..   |:...||.:.....| .|
Yeast   337 ----DGAEASHPDHQVLSRSRSQSTSFVQGKGGKRKSIEDEGYHNKLGLPHGSGPTSVYNNK-SN 396

  Fly   610 IASFINASSHRLR--LQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILN 672
            ..|.|...|.|..  :.:....|.:.|..|:..:|                    |:||:...|.
Yeast   397 ANSTITGMSRRSSSIVNALSSFVNLRSSSLSSSRQ--------------------QHLQQQQQLQ 441

  Fly   673 AELDPMQVALFLRENPGLDK------------------KMIGEYISKKKNVDSKILINFV--DSF 717
            .:||     :.|.:.|.:..                  |.||..:::|.:...|..:|::  :.|
Yeast   442 QKLD-----VSLEDLPPVPAPEFSDSCKDFLIKLAPYGKFIGIILTEKDDEFKKNCLNYLLTNCF 501

  Fly   718 DFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQD---------PFANVDAAFRLA 773
            :|....:|.|||..|....||.|...|..::..||..::|..:.         |::|.|..:.:|
Yeast   502 EFKNDPLDIALRKLLMFLELPKETQQIDRLIMAFSFAYYKAQKSYSKKKGIECPWSNADQVYFIA 566

  Fly   774 YAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRG--LNGGEDFDQEMLAQVFNAIKNEEIVMPAEQ 836
            ::::||:.|..|.|.|.   .||..||...:..  .:||.:....:|...:..:..:|
Yeast   567 FSLLMLHTDYFNPNNKS---KMTKHDFVDLVHNDKYSGGNEIPMAVLTYFYENVTAKE------- 621

  Fly   837 TGLVRENYQWKVLLRRGDTHDGHFHY-------VHDASYDVEIFNIVWGASLSALSF-----MFD 889
                                ...|:|       :.|:..|.:.|:..:..:||:.|.     |..
Yeast   622 --------------------SPKFNYFLMSPMALDDSILDKDAFDTNFAITLSSNSMYSPIDMIK 666

  Fly   890 KSTETGYQRTL-------------AGFSKSAAISAHYNLHSDFDALVLTLCKFTTL-------LS 934
            :.:....:.:|             :|.:.|.|.|                |..:|.       |.
Yeast   667 RGSIIPKEASLSPIFYPLTNSISASGIAPSTAAS----------------CPPSTSGTINGANLG 715

  Fly   935 SVEQHEPAPANNETQQAVNF----GLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRL 995
            :...:...||:|......::    ..:|.|......:.:..|...|.|.|              :
Yeast   716 TANSNSNRPASNSISSYFSYNPSSSSSGNATLVQDDINVYSHIINDTLNE--------------V 766

  Fly   996 KLLPKSLIEVEDFCEANG-KAMLILEKPREKQESGLFSSLYSFISSEGQREPTYEEQDFIKLG-- 1057
            .|.|    ||..:...|. ||.|:      :.|...:...||.::........:.:....||.
Yeast   767 NLFP----EVSKYWNKNALKANLL------RNEEHKYEKYYSIMNDTKGGYLRFHKSQLNKLNLP 821

  Fly  1058 --------------RKCIKECQLDQM-------LQESKFVQLESLQELLKCVLALLKAPQGHKSI 1101
                          ....|.|::.||       :...||..:.|.:...|...|:|      .|:
Yeast   822 NFEILNDNSRSGCKNSDYKYCKILQMGAIMNLGMPSRKFSIVNSAKIHWKKEFAIL------TSL 880

  Fly  1102 GLPYAEDQTVFWMEFLVKIVVHNRDRMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLA 1166
            ||                ::....|.:.|  ..::|..    .|:.:...|:......|....:.
Yeast   881 GL----------------LICDKMDWINP--QMMKDPK----SGTTNYIIDFKSGFSFVPGSTID 923

  Fly  1167 IY--LMRNEELCPIVLQSLKMLLMLKPALLLRISKQISIGIYELLKTSAQNI--HSEQDWQIIFN 1227
            :|  |..:.|...:.....       .:|:|..::..|.|.:....|:|.:.  |:|
Yeast   924 VYNGLFADRERDSLGKSHF-------ASLVLAYTEHHSTGSHTSNTTAASSSAKHNE-------- 973

  Fly  1228 LLECVGAGAVPPNYDDAQLPLPPNGSAKSDGAISGEEDATAVPERGYTSDSEITKASAAPAVSSP 1292
                   |...|:.|:             :.:|:...|.|:....| .||::...:|.....|:.
Yeast   974 -------GVFEPSSDE-------------EDSITNSTDGTSSVSNG-ESDNDSVSSSDNQLSSND 1017

  Fly  1293 SAENWILVNNKDSELTTASRPQSPPSLSAPPVNTLVY--NCQLLDHAPFALFKC--------W-D 1346
            |.|::..:  ||..          |.......:.|:|  .|    |..| ::||        | |
Yeast  1018 SNEDYHSI--KDEY----------PIFEDENADCLLYLHTC----HRNF-IWKCANKYERDNWID 1065

  Fly  1347 SLAFIVRSVAHITPYNFEACVRCIRIFVE-------ACRDGGIRQRRKLESAAKQKSSKKRSERK 1404
            |:..            |.|...|   :||       .|....:...:::|.....||:|....:|
Yeast  1066 SINL------------FSAYDGC---YVEIGSIANTICNKRKLTILQRMERLRSIKSAKWEKLKK 1115

  Fly  1405 PGMASSASSSNLTLLTGDPSDNQINGNAAEQEDLAQRYEQLSIQLLDLMYTLYTRTAQIF 1464
                   ..|.|.|:     ...:..:...:.|:..|..||::::..|:|.:  :.:::|
Yeast  1116 -------FESTLMLM-----GKCVPISTKTKTDMINRIRQLAVRMDWLIYEI--KRSELF 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	133/806 (17%)
		Sec7_N	370..512	CDD:289549	14/141 (10%)
		Sec7	643..830	CDD:279680	45/217 (21%)
SYT1	NP_015420.1	COG5307	141..1221	CDD:227623	235/1341 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910