Protein Alignment garz and GEA1

DIOPT Version :10

• Sequence 1: NP_610761.2
• Gene: garz / 36337
• FlyBaseID: FBgn0264560
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_012565.1
• Gene: GEA1 / 853488
• SGDID: S000003792
• Length: 1408
• Species: Saccharomyces cerevisiae
• Alignment Length: 1531
• Identity: 348/1531 - (22%)
• Similarity: 599/1531 - (39%)
• Gaps: 445/1531 - (29%)

  Fly    38 NDSLLKLFIDLKHELNRIEDLRQIEPQVFLAPFLEVIRTADATGPLTSLALASVNKLLSYGLIDP 102
            :|.|:...:.|:.::|.::.|..:.....|.||||::..:..:|..|||||.|:.|:.:..:|:.
Yeast    72 HDPLISGLVQLRLKINDLKGLDSLNALELLKPFLEIVSASSVSGYTTSLALDSLQKVFTLKIINK 136

  Fly   103 TSPNLADIVERIADAVTHARFMGTDQSSDGVTFMRVIEVLHTLIRSPEGAAVSNVSMCEVMLSCF 167
            |..::...|.....|:||.||..:.|.||....::|:.:|..:|.|..|..:|:..:.:|:.:..
Yeast   137 TFNDIQIAVRETVVALTHCRFEASKQISDDSVLLKVVTLLRDIITSSFGDYLSDTIIYDVLQTTL 201

  Fly   168 KISFEPRLSELLRRSAEKSLKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAASGATQEKLKRKT 232
            .::...:.||:||::||.::..:.:..|.:|                            ||
Yeast   202 SLACNTQRSEVLRKTAEVTIAGITVKLFTKL----------------------------KL---- 234

  Fly   233 VAQAQTAPRKSSAVEEPPQTPQSAN--LTVPGHLKAPILATTPASPAGNILDMQGKITQTPTTTA 295
                         ::.|.:|.:..|  .....:||..|:.||                 |.....
Yeast   235 -------------LDPPTKTEKYINDESYTDNNLKDDIIGTT-----------------TSDNDL 269

  Fly   296 STGEDETTVP-----ETPVIQVESTESEPLLDGETGEATSTLAEANSSEYINSVGVRFTQQSTDH 355
            |:.:|::.|.     |.||.||       :.:.|..|.|:..||
Yeast   270 SSTDDDSAVADDNKNEKPVQQV-------IREQENDEETAEKAE--------------------- 306

  Fly   356 DVTSLSP-YGLPFIQELFRFLIILCNPLDK-QNSDSMMHTGLSLLTVAFEVAADNIGKYEGLLEL 418
               ::.| ||:..|::....|:.|..|.:: :::.|.|...|.|:..|.|::.|....|..|..|
Yeast   307 ---NVEPNYGITVIKDYLGLLLSLVMPENRMKHTTSAMKLSLQLINAAIEISGDKFPLYPRLFSL 368

  Fly   419 VKDDLCRNLISLL-SSERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEI-----IASD-N 476
            :.|.:.::::.:: ||.:.|:..|.|||...|...|..:|..|:|..||::.||     |:.| :
Yeast   369 ISDPIFKSVLFIIQSSTQYSLLQATLQLFTSLVVILGDYLPMQIELTLRRIFEILEDTTISGDVS 433

  Fly   477 PKTPYEMRELALDNLLQLW-RIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTLSATNAVYSTH 540
            .:.|..:|||.::.|..|| ..|.|..:|::|:||:|..:|:.......|:|::|.
Yeast   434 KQKPPAIRELIIEQLSILWIHSPAFFLQLFVNFDCNLDRSDLSIDFIKELTKFSLP--------- 489

  Fly   541 IISMDTLLSVIDSIERNCAASKNSSNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEE 605
                              ||:.|:|||   :|...              |||::          .
Yeast   490 ------------------AAAVNTSNN---IPPIC--------------LEGVL----------S 509

  Fly   606 KVENI---------ASFINASSHRLRLQSGGEGVGITSEQLAKVKQKKR----LLSQGTERFNQR 657
            .:|||         |.|:.                 ..:::..:||:.|    :|.  .|.||::
Yeast   510 LIENIYNDLQRFDRAEFVK-----------------NQKEIDILKQRDRKTEFILC--VETFNEK 555

  Fly   658 PEKGIQYLQEHGILNAELDPMQVALFLRENPG-LDKKMIGEYISKKKNVDSKILINFVDSFDFTG 721
            .:||||.|.|.|.::::.: ..:|.||..|.| |:||.||..:...|.  :.:|..|:|.|||.|
Yeast   556 AKKGIQMLIEKGFIDSDSN-RDIASFLFLNNGRLNKKTIGLLLCDPKK--TSLLKEFIDLFDFKG 617

  Fly   722 LRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHW---------------------HKQNQDPFAN 765
            ||||:|:|:.|..||||||:..|..::|.||..:                     ....:|...:
Yeast   618 LRVDEAIRILLTKFRLPGESQQIERIVEAFSSKYSADQSNDKVELEDKKAGKNGSESMTEDDIIH 682

  Fly   766 V----DAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIK 826
            |    |:.|.|:|:|||||.|.||...|.   .||.:|::.||||...|:||.:..|.:::.:||
Yeast   683 VQPDADSVFVLSYSIIMLNTDSHNPQVKD---HMTFDDYSNNLRGCYNGKDFPRWYLHKIYTSIK 744

  Fly   827 NEEIVMPAEQTGLVRENYQW------------KVL--LRRGDTHD-GHFHYVHDASYDVEIFNIV 876
            .:|||||.|..|    |.:|            .|:  ::|..|:. .....:....|:..||:.|
Yeast   745 VKEIVMPEEHHG----NERWFEDAWNNLISSTSVMTEMQRDFTNPISKLAQIDILQYEKAIFSNV 805

  Fly   877 WGASLSALSFMFD-KSTETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSS----- 935
            ....|..|..:|. .|::....|.|...||...|:.:::....::..||.|.:.|||..|
Yeast   806 RDIILKTLFKIFTVASSDQISLRILDAISKCTFINYYFSFDQSYNDTVLHLGEMTTLAQSSAKAV 870

  Fly   936 -----------VEQHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGD---CLRESWKHIL 986
                       :...:.....:.:.|::..|.|.|||......|.::.:..|   .....|..|:
Yeast   871 ELDVDSIPLVEIFVEDTGSKISVSNQSIRLGQNFKAQLCTVLYFQIIKEISDPSIVSTRLWNQIV 935

  Fly   987 DLYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEKP-----REKQESGLFSSLYSFISSEGQREP 1046
            .|.|:||...|:..:|....:|........|.|..|     :.|....|.|:..|::  :|..||
Yeast   936 QLILKLFENLLMEPNLPFFTNFHSLLKLPELPLPDPDISIRKAKMSRSLLSTFASYL--KGDEEP 998

  Fly  1047 TYEEQDFIKLGRKCIKECQ-LDQMLQESKFVQLESLQELLKCVLALLKAPQGHKSIGLPYAEDQT 1110
            :.|:.||.....:|:|... |..:.:.::.|..:.::.||.. |.:.|..:..     ||.|.:.
Yeast   999 SEEDIDFSIKAFECVKASHPLSSVFENNQLVSPKMIETLLSS-LVIEKTSENS-----PYFEQEL 1057

  Fly  1111 VFWMEFLVKIVVHNRDRMIPLWPAVRDQMYLLLMGSASCGY-------DYLLNRCIV------AV 1162
            :|.:|                       :.::|:..||.|.       |:::|...:      |:
Yeast  1058 LFLLE-----------------------ISIILISEASYGQEFGALIADHMINISNLDGLSKEAI 1099

  Fly  1163 LKLAIY-----------------------LMRNE---------ELCPIVLQSL-----------K 1184
            .:||.|                       |::||         |....|:..|           :
Yeast  1100 ARLASYKMFLVSRFDNPRDILSDLIEHDFLVKNEIFNTKYYESEWGKQVINDLFTHLNDVKYNER 1164

  Fly  1185 MLLMLKPALLLRI---SKQISIGIYELLKTSAQN---IHSEQDWQIIFNLLE---CVGAGAV--P 1238
            .|..:|....|||   :|.....:|..|:...||   ...:.::..|.:||:   |.||...  .
Yeast  1165 ALKNVKFWNFLRILISAKDRQFAVYTFLEKYIQNGDIFVDDGNFMNILSLLDEMSCAGAVGTKWE 1229

  Fly  1239 PNYDDAQLPLPPNGSAKSDGAISGEEDATAVPERG-YTSDSEITKASAAPAVSSPSAENWILVNN 1302
            .||:::                  .||....||.. |.|..:::..|               :|.
Yeast  1230 QNYENS------------------VEDGCEAPESNPYRSIIDLSSRS---------------INI 1261

  Fly  1303 KDSELTTASRPQSPPSLSAPPVNTLVYNCQLLDHAPFALFKCWDSLAFIVRSVAHITPYNFEACV 1367
            ....|:|..|..|                        ||.|  :.:...::.:||
Yeast  1262 TADLLSTVGRSNS------------------------ALNK--NEIIAAIQGLAH---------- 1290

  Fly  1368 RCIRIFVEACRDGGIRQRRKLESAAKQKSSKKRSER 1403
            :|:    ..|.:.|::..:.||:....::|:.|:|:
Yeast  1291 QCL----NPCDELGMQALQALENILLSRASQLRTEK 1322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	PLN03076	<395..>986	CDD:215560	178/672 (26%)
		Sec7	643..830	CDD:460178	75/216 (35%)
GEA1	NP_012565.1	Sec7_N	328..471	CDD:463703	43/142 (30%)
		Sec7	541..748	CDD:460178	75/214 (35%)