Protein Alignment garz and SEC7

DIOPT Version :9

• Sequence 1: NP_610761.2
• Gene: garz / 36337
• FlyBaseID: FBgn0264560
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_010454.3
• Gene: SEC7 / 851748
• SGDID: S000002577
• Length: 2009
• Species: Saccharomyces cerevisiae
• Alignment Length: 2219
• Identity: 424/2219 - (19%)
• Similarity: 768/2219 - (34%)
• Gaps: 760/2219 - (34%)

  Fly     1 MALPGNG------IYVVRGEMATLMTAMRRGTRWNATAYVDDENDSLLKLFIDLKHELNR-IEDL 58
            ::|..||      |.:|:..:.|::                  ||..:|...:.:..:.| ::..
Yeast   211 ISLSSNGSNTNSTIILVKTTLETIL------------------NDKDIKKNSNAQKAIERTLQKF 257

  Fly    59 RQIEPQVFLAP-------FLEVIRTADAT--GPLTSLALASVNKLLSYGLIDPT---SP--NLAD 109
            ::.:||....|       ..|.:|.:..|  ..:.||||..::||.|:..:|.|   :|  :||.
Yeast   258 KEFDPQTTNNPHYVDSILVFEALRASCRTKSSKVQSLALDCLSKLFSFRSLDETLLVNPPDSLAS 322

  Fly   110 IVERIADAVTHARFMGTDQSSDGVT---FMRVIEVLHTLIRSPEGAAVSNVSMC----------- 160
            ..:|             ..::||:|   ..::|:           ||:..:|.|
Yeast   323 NDQR-------------QDAADGITPPPKQKIID-----------AAIDTISDCFQGEGTDDRVE 363

  Fly   161 ----EVMLSCFKISFEPRLSELLR-RSAEKSLKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAA 220
                ..:.||.   .|...|.|.. .|..|:::.:..:|.                  |::..:.
Yeast   364 LQIVRALSSCI---LEEDSSSLCHGASLLKAIRTIYNVFV------------------FSLNPSN 407

  Fly   221 SGATQEKLKRKTVAQAQTAPRKSSA---VEEPPQTPQSANLTVPGHLKAPILATTPAS-----PA 277
            .|          :|||......||.   ::....|..:.:|:...|.:...:..:.||     ||
Yeast   408 QG----------IAQATLTQIISSVYDKIDLKQSTSSAVSLSTKNHQQQSAIELSEASENAETPA 462

  Fly   278 GNILDMQGKITQTPTTTASTGEDETTVPETPVIQVESTESEPLLDGETGEATSTLAEANSSEYIN 342
            ...|:...|:          .:||                |.|:|.:..:
Yeast   463 PLTLENMDKL----------NDDE----------------ERLMDAQQPD--------------- 486

  Fly   343 SVGVRFTQQSTDHDVTSLSPYGLPFIQELFRFLIILC-NPLDKQNSDSMMH---TGLSLLTVAFE 403
            |:.:      |:.|:.....:      .:||.:..:| .||:.: .|...|   :.|..|.:.:.
Yeast   487 SIAI------TNQDLAVKDAF------LVFRVMAKICAKPLETE-LDMRSHAVRSKLLSLHIIYS 538

  Fly   404 VAADNI-----------GK-----YEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFES 452
            :..|:|           ||     .:.:.:.::..|.||..|.|:    .:|...|::.:||..:
Yeast   539 IIKDHIDVFLSHNIFLPGKERVCFIDSIRQYLRLVLSRNAASPLA----PVFEVTLEIMWLLIAN 599

  Fly   453 LRGHLKFQLEAYLRK----LSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDL- 512
            ||.....::..:|.:    :||:..|.:.:..|     .|..:.::...|..:.|.|:||||:.
Yeast   600 LRADFVKEIPVFLTEIYFPISELTTSTSQQKRY-----FLSVIQRICNDPRTLVEFYLNYDCNPG 659

  Fly   513 ----------YCTDMF---------------ESLTNLLSKYTLSATNAVYSTHI----------- 541
                      |.|.:.               |.::..||.|..|....:.|:::
Yeast   660 MPNVMEITVDYLTRLALTRVEITQTQRSYYDEQISKSLSTYNFSQLPLLTSSNLSSSPDVGQVNL 724

  Fly   542 ----------ISMDTLLSVIDSIERNCAASKNSSN---NRESLPEAAPATGGSRHSRHNSGLEGI 593
                      :|::.::||:.|:......:.|.:.   |:..|...:.|...||.|..|.....|
Yeast   725 LFPLDFALKMVSLNCIVSVLRSLSSWAHKALNPNTHTANKVLLNTTSSARQESRSSLSNDVRSSI 789

  Fly   594 VI--DSGNSVAAEEKVENIAS-FINASSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERFN 655
            :.  |.......:|:..:::| .|:|..               ..|...:|.:|..||:....||
Yeast   790 MTSNDDFKPTYEDEESRSLSSQNIDADD---------------PTQFENLKLRKTALSECIAIFN 839

  Fly   656 QRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFT 720
            .:|:|.|..|.:.|.|..: .|:.:|.:|.|..|||...:|:|:.:..:.:..|:..|||.||||
Yeast   840 NKPKKAIPVLIKKGFLKDD-SPISIAKWLLETEGLDMAAVGDYLGEGDDKNIAIMHAFVDEFDFT 903

  Fly   721 GLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQHN 785
            |:.:..|||.:|::||||||...|...:..|::.:..||...|:..|.|:.|:|::||||.|.|:
Yeast   904 GMSIVDALRSFLQSFRLPGEGQKIDRFMLKFAERFVDQNPGVFSKADTAYVLSYSLIMLNTDLHS 968

  Fly   786 SNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPAEQ--------TGLV-- 840
            |..|.   .|:|::|.:|..|::.|.|..::.|..:||.|.|.||.:.:||        |.||
Yeast   969 SQIKN---KMSLQEFLENNEGIDNGRDLPRDFLEGLFNEIANNEIKLISEQHQAMLSGDTNLVQQ 1030

  Fly   841 --------------RENYQ-------------WKVLLRRGDTHDGHF---HYVHDASYDVEIFNI 875
                          ||.|.             :|.|.:.....|.::   |..|..|    ||..
Yeast  1031 QQSAFNFFNSRDLTREAYNQVSKEISSKTELVFKNLNKNKGGPDVYYAASHVEHVKS----IFET 1091

  Fly   876 VWGASLSALSFMF-DKSTETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQH 939
            :|.:.|:||:..| |........:.|.|...|..|::.:.::....:.|..|.:|.. |.::|:.
Yeast  1092 LWMSFLAALTPPFKDYDDIDTTNKCLEGLKISIKIASTFRINDARTSFVGALVQFCN-LQNLEEI 1155

  Fly   940 EPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIE 1004
            :....|                 ||..:..:....|:.|..|||.||.:..|:.||:|:.|.:..
Yeast  1156 KVKNVN-----------------AMVILLEVALSEGNYLEGSWKDILLVVSQMERLQLISKGIDR 1203

  Fly  1005 --VEDFCEANGKAMLILEKPREKQESGLFSSLYSFISSEGQR-EPT------YEEQDFIKLGRKC 1060
              |.|..:|.      :..||...||.. |:..||....|:: .||      :..|.......|.
Yeast  1204 DTVPDVAQAR------VANPRVSYESSR-SNNTSFFDVWGKKATPTELAQEKHHNQTLSPEISKF 1261

  Fly  1061 IKECQL----DQMLQESKFVQLESLQELLKCVLAL-LKAPQGHKSIGLPYAEDQTVFWMEFLVKI 1120
            |...:|    |.:..:|..:...::.:.:|.:.|: |:..:..::...|     .:|.::.:|.:
Yeast  1262 ISSSELVVLMDNIFTKSSELSGNAIVDFIKALTAVSLEEIESSENASTP-----RMFSLQKMVDV 1321

  Fly  1121 VVHNRDRM----IPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLAIYLMRN--------E 1173
            ..:|.||:    .|||         .:||.|   ::.:.....:||:..||..:|.        |
Yeast  1322 CYYNMDRIKLEWTPLW---------AVMGKA---FNKIATNSNLAVVFFAIDSLRQLSMRFLDIE 1374

  Fly  1174 ELCPIVLQSLKMLLMLKPALLLRISKQISIGIYELLKTSAQNIHSEQDWQIIFNLLECVGAGAVP 1238
            ||.....|                        ::.||.....:.:..:.::...::||.
Yeast  1375 ELSGFEFQ------------------------HDFLKPFEYTVQNSGNTEVQEMIIECF------ 1409

  Fly  1239 PNYDDAQLPLPPNGSAKSDGAISGEEDATAVPERGYTSDSEITKASAAPAVSSPSAENWILVNN- 1302
                 ....|..:.|.||                |:....|..:.:|..:..|...:..:||:|
Yeast  1410 -----RNFILTKSESIKS----------------GWKPILESLQYTARSSTESIVLKTQLLVSND 1453

  Fly  1303 ------------KDS---------ELTTASRPQSPPSLSAPPVNTLVYNCQLLDHAPFALFKCWD 1346
                        :|:         |:|...|.|                 :|..||       .:
Yeast  1454 IVTNHFENVFSQEDAFSELVGVFREITKNKRFQ-----------------KLSLHA-------LE 1494

  Fly  1347 SLAFIVRSVAHITPYNFEACVRCIRIFVEACRDGGIRQRRKLESAAKQKSSKKRSERKPGMASSA 1411
            ||..:.::||.|..||                                 .:|...|||
Yeast  1495 SLRKMTQNVADICFYN---------------------------------ENKTEEERK------- 1519

  Fly  1412 SSSNLTLLTGDPSDNQI--------NGNAAEQEDLAQR----------------------YEQLS 1446
              .|..||.|......:        |......|||..|                      :|::.
Yeast  1520 --HNDALLRGKDIFQDVWFPMLFCFNDTIMTAEDLEVRSRALNYMFDALVAYGGKFNDDFWEKIC 1582

  Fly  1447 IQLLDLMYTLYTRTAQIFRWWAEEGCTVPQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCL 1511
            .:||..::.:.::..::.::.:.:..:|..|..        |:|.:..|.
Yeast  1583 KKLLFPIFGVLSKHWEVNQFNSHDDLSVWLSTT--------LIQALRNLI--------------- 1624

  Fly  1512 QQRALLVHDLQTLSGTEWCSCFHQVLFPLLNELLPESNAAGQLDAALLEE----SRIRTATIMSK 1572
               ||..|                 .|..||.:|  ....|.|.:.:.:|    :|| ..:.:.:
Yeast  1625 ---ALFTH-----------------YFESLNRML--DGFLGLLVSCICQENDTIARI-GRSCLQQ 1666

  Fly  1573 VFLQHLTTLIE-----LGNAFNELW-----LDILDY--IERFMKVG-------------SDTLSE 1612
            :.||:::...|     :|:.|::|:     .::.||  :::..|..             ||..|.
Yeast  1667 LILQNVSKFNEYHWNQIGDVFDKLFDLTTANELFDYDPLQQGRKSSVSHHQTTNDTSQHSDDDSN 1731

  Fly  1613 QMQEILKNMLLVMHSVRVFHNQD------GSLQQALWELTWRRIGEFLPNLKEELFHDEGKRAQT 1671
            ..:|...|   :..:|...|.::      |.:.:.|...|....|..:|.:|:||
Yeast  1732 DRRENDSN---ISETVERAHQEESSEDVGGDMVETLNGQTKLNNGNSVPTVKDEL---------- 1783

  Fly  1672 LTNPAPQAAVAAAPQQQLPAVT----------ILPRQTQVSNELVVSAPTPPAATPLLGSPVES- 1725
              ||.|.:.       .:|..|          .:.|:..:.|.:||..........||....|:
Yeast  1784 --NPKPASL-------SIPKKTKHMKRNESNEDIRRRINIKNSIVVKCVLQLLMIELLNELFENE 1839

  Fly  1726 ------PRRSIILQPPMADVLQQPPSFVFAQPI---------IVPPQPPAVTDPIPPSTLLPDLV 1775
                  |.:..|   .:..:|::  |:.|::..         :|..:   |.|.|      |:|:
Yeast  1840 DFAHCIPYKEAI---RITRLLEK--SYEFSRDFNEDYGLRTRLVEAR---VVDKI------PNLL 1890

  Fly  1776 NEATAAAVQATTTSPTHSPQEAEQPASIVQQTNIVT-------------------TNNTYNSYAI 1821
            .:.|:||.............:.|:.|.::  |.::|                   :.|.:.|..:
Yeast  1891 KQETSAAAVLLDIMFQLYLNDDEKKADLI--TRLITICIQVVEGYVSLDDRTMERSINAWRSVIV 1953

  Fly  1822 EVPMAPETTAEQFGQQQQQLLYQQYYQQYQAQQQQLPAPAS--------DPAINVPISHLL---- 1874
            |:                   .|.|| ::..:..:|..||.        |.::...:.|.:
Yeast  1954 EI-------------------LQGYY-EFDDEDFRLYCPAMYALVIQILDKSVPTELRHAIKQFL 1998

  Fly  1875 --AGNAYPS 1881
              .|..|.|
Yeast  1999 SRVGELYLS 2007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	198/842 (24%)
		Sec7_N	370..512	CDD:289549	37/165 (22%)
		Sec7	643..830	CDD:279680	68/186 (37%)
SEC7	NP_010454.3	DCB	<283..426	CDD:406594	37/197 (19%)
		COG5307	504..1693	CDD:227623	293/1426 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810