DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment garz and iqsec2b

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_005167294.1	Gene:	iqsec2b / 797187	ZFINID:	ZDB-GENE-081105-73	Length:	1581	Species:	Danio rerio

Alignment Length:	1296	Identity:	264/1296 - (20%)
Similarity:	413/1296 - (31%)	Gaps:	474/1296 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   545 DTLLSVIDSIER-NCAASKNSSNNRESLPEAAPATGG---SRHSRHNSGLEGIVIDSGNSVAAEE 605
            |:|.|..:|.|. ||:   :.|::|:||.|..|..|.   .|.||||          .:|.|...
Zfish   631 DSLNSTTNSNETINCS---SGSSSRDSLREPLPPLGKQTYQRESRHN----------WDSPAFNN 682

  Fly   606 KVENIASFINASSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGI 670
            .|      :....:|:                            |...||::||||||||.|.|.
Zfish   683 DV------VQRRQYRI----------------------------GLNLFNKKPEKGIQYLIEKGF 713

  Fly   671 LNAELDPMQVALFLRENPGLDKKMIGEYI-SKKKNVDSKILINFVDSFDFTGLRVDQALRLYLET 734
            ::.  .|:.:|.|:.|..||.::||||:: :::|..:..:|...||..||:|:.:|.|||.:...
Zfish   714 VSD--TPVGIARFILERKGLSRQMIGEFLGNRQKQFNKDVLDCVVDEMDFSGMDLDDALRKFQAQ 776

  Fly   735 FRLPGEAPLIFLVLEHFSDHWHKQNQ---DPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMT 796
            .::.|||..:..::|.||..:...|.   ..|.|.|..|.||:|||:||.|.::.|.| ....|.
Zfish   777 IKVQGEAQKVERLIEAFSQRYCVCNPALVRQFQNPDTIFILAFAIILLNTDMYSPNIK-AERKMK 840

  Fly   797 LEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENYQWKVLLRRGDTHDGHFH 861
            |:||.|||||::.|::..:::|..::..|:                  :|:  ||..|.|.....
Zfish   841 LDDFIKNLRGVDNGQEIPRDLLVGIYQRIQ------------------KWE--LRTNDDHVSQVQ 885

  Fly   862 YVHDASYDVEIFNIVWGASLSALSFMFDKSTETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTL 926
            .|                                 :|.:.|  |...:|..:.
Zfish   886 AV---------------------------------ERVIVG--KKPVLSLPHR------------ 903

  Fly   927 CKFTTLLSSVEQHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQ 991
                .|:...:.||....|...:..|:          .|.|||    :.|
Zfish   904 ----RLVCCCQLHEVPDPNRPQRSGVH----------QREVFL----FND--------------- 935

  Fly   992 LFRLKLLPKSLIEVEDFCEANGKAMLILEKPREKQESGLFSSLYSFISSEGQREPTYEEQDFIKL 1056
                                    :|::.|..:|:::   |..|||    .|..|..|.|
Zfish   936 ------------------------LLVVTKIFQKKKT---SVTYSF----RQSFPLVEMQ----- 964

  Fly  1057 GRKCIKECQLDQMLQESKF---VQLESLQELLKCVLALLKAPQGHKSIGL----PYAEDQTVFWM 1114
                      ..|.|.|.:   |:|.|            ..|.|.:.:.:    |..:|:|.|
Zfish   965 ----------VHMFQNSYYPHGVRLTS------------AIPGGERKVLIVFTAPSQQDRTRF-- 1005

  Fly  1115 EFLVKIVVHNRDRMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLAIYLMRNEELCPIV 1179
                                |.|                 |...|..|.::..|.:.:|
Zfish  1006 --------------------VSD-----------------LRESIAEVQEMEKYRVESE------ 1027

  Fly  1180 LQSLKMLLMLKPALLLRISKQISIGIYELLKTSAQNIHSEQDWQIIFNLLECVGAGAVPPNYDDA 1244
            |:..|.  :::|:||   :..|..|....:|....|              ..:|..::..||.
Zfish  1028 LEKQKG--VMRPSLL---TNSIMAGGVGGVKNEVVN--------------GTMGRPSLDDNYS-- 1071

  Fly  1245 QLPLPPNGSAKSDGAISGEEDATAVPERGYTSDSEITKASAAPAVSSPSAENWILVNNKDSELTT 1309
                 |....|.....|...|.:...:||..:             |..|.::.:.|:..::|.:|
Zfish  1072 -----PGEGLKRTALSSSLRDLSESGKRGRRN-------------SVGSLDSTMEVSLSEAEQST 1118

  Fly  1310 ASRPQSPPSLSAPPVNTLVYNCQLLDHAPFALFKCWDSLAFIVRSVAHITPYNFEACVRCIRIFV 1374
            || |..|.|..:|.:                   .||..  :..|..|..|
Zfish  1119 AS-PALPSSHCSPRM-------------------LWDRR--LPASPPHPEP-------------- 1147

  Fly  1375 EACRDGGIRQRRKLESAAKQKSSKKRSERKPGMASSA----SSSNLTLLTGDPSDNQINGNAAEQ 1435
               |.||                       .|.|.:|    |......|......|..||: .||
Zfish  1148 ---RSGG-----------------------GGWAGAATHTCSDWRWASLQQHRERNDWNGD-WEQ 1185

  Fly  1436 EDLAQRYEQLSIQLLDLMYTLYTRTAQIFRWWAE----EGCTVPQSAALWSPGWCPLLQGIARLA 1496
            :...:.:..|.:                   |.:    .|...|..|.|..|  |    |.|
Zfish  1186 QQQHRFFPGLPV-------------------WGQAIQSPGSYYPPGATLPRP--C----GPA--- 1222

  Fly  1497 MDRRREVRTHAISCLQQ-----------RALLVHDLQTLSGTEWCSCFHQVLFPLLNELL----- 1545
             |.||...:..:..:..           |.:|.|..|....|...........|..:..|
Zfish  1223 -DYRRPTASVPVLAVPDGRWTFQDPGPARPVLPHYQQQCQWTASAPVLPPPPLPYTDRTLNWAAR 1286

  Fly  1546 PESNAAGQLDAALLEESRIRTATIMSKVFLQHLTTLIELGNAFNELWLDILDYIERFMKVGSDTL 1610
            |..::||.| |:......:|...|.:.:......:|.|.|           .:.:..::..|...
Zfish  1287 PSYSSAGHL-ASSAAPQPLRALPIPADLPAYFAGSLREHG-----------QHGQHGLRPPSPPF 1339

  Fly  1611 SEQMQEILKNMLLVMHSVRVFHNQDGSLQQALWELTWRRIGEFLPNLKEELFHDEGKRAQTLTNP 1675
            |.........:..|.|:.... .|.|..|||             |:....|   ....|:||.:|
Zfish  1340 SSLPTLPSPAVCSVPHTAYTL-GQRGRHQQA-------------PSHVVTL---AAPPARTLPHP 1387

  Fly  1676 APQAAVAAAP----------QQQLPAVTILPRQTQVSNELVVSAPTPPAATPLLGSPVESPRRSI 1730
             |:.....||          :.:.|:.:.||.....::.|.|....|.||    |.||.:|..::
Zfish  1388 -PRPCANTAPHLPPRAPTSLRLRQPSASALPCSHSAASSLRVRHCPPRAA----GRPVSAPVSTV 1447

  Fly  1731 ILQPPMADVLQQPPSFVFAQPIIVPPQPPAVTDPIPPSTLLPDLVNEATAAAVQATTTSPT 1791
            :|..|      .||...|..|.: ||.|...:.|.||....|......:|.|:.::..|.|
Zfish  1448 VLHSP------SPPPLPFTPPFL-PPYPSYASLPSPPPAPRPTFPGRGSARALTSSDWSRT 1501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	121/524 (23%)
		Sec7_N	370..512	CDD:289549
		Sec7	643..830	CDD:279680	67/190 (35%)
iqsec2b	XP_005167294.1	Sec7	686..871	CDD:279680	68/233 (29%)
		IQ_SEC7_PH	899..1026	CDD:293062	40/268 (15%)
		PH	926..1014	CDD:278594	31/213 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582822
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840