DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and Psd

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_001334383.1	Gene:	Psd / 73728	MGIID:	1920978	Length:	1025	Species:	Mus musculus

Alignment Length:	904	Identity:	185/904 - (20%)
Similarity:	302/904 - (33%)	Gaps:	285/904 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 GHLKAPILATTPAS---PAGNILDMQGKITQTPTTTASTGEDETTVP-----ETPVIQV------ 312
            |.|.||.....|..   |:..:...||...........:..|...||     ||.:.:|
Mouse   245 GSLDAPSSGAKPPEQVLPSRGVGSKQGSGVAVGRAAKYSETDLDKVPLRCYRETDIDEVLAEREE 309

  Fly   313 --ESTESEPLLDGETGEA-------------TSTLAEANSSEYINSVGVRFTQQSTDHDVTSLSP 362
              .:.||:|..:|..|.|             :|:|...|..:....      ::..|.:|...|.
Mouse   310 ADSAIESQPSSEGPHGTAQPPASRPSPCPGPSSSLGSGNEDDEAGG------EEDVDDEVFEASE 368

  Fly   363 YGLPFIQELFRFLIILCNPLDKQNSDSMMHTGLSLLTVAF----EVAADNIGKYEGLLELVKDDL 423
            ...|                    .|.|.|:||....|.|    ..:||....:..:.|.:.:..
Mouse   369 GARP--------------------GDHMPHSGLLKSPVPFLLGTSPSADGPDSFSCVFEAILESH 413

  Fly   424 CRNLISLLSSERLSIFAA--DLQLCFLLFESLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMREL 486
            .....|..|...|...|:  ..|..|..||     :..|..|         ...:|..|..:..|
Mouse   414 RAKGTSYSSLASLEALASPGPTQSPFFTFE-----MPPQPPA---------PRPDPPAPAPLAPL 464

  Fly   487 ALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTLSATNAVYSTHIISMDTLLSVI 551
            ..|:                                     .|.||.:..::..
Mouse   465 EPDS-------------------------------------GTSSAADGPWTQR----------- 481

  Fly   552 DSIERNCAASKNSSNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINA 616
            ..:|.:.|.:..:.  |:.||..:       ||..:.||....:.|     :|..:..:.|..::
Mouse   482 REVEESDAGATLAP--RKELPSPS-------HSEDSFGLGAAPLGS-----SEPPLSQLVSDSDS 532

  Fly   617 ---SSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPM 678
               |:.||.|   |....:::.|.|.::..:||            .|.:..|.  |...|:
Mouse   533 ELDSTERLAL---GSTDTLSNGQKADLEAAQRL------------AKRLYRLD--GFRKAD---- 576

  Fly   679 QVALFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPL 743
             ||..|.:|....|.:.|||:.               .|.|||:.:|||||::|:...|.||...
Mouse   577 -VARHLGKNNDFSKLVAGEYLK---------------FFVFTGMTLDQALRVFLKELALMGETQE 625

  Fly   744 IFLVLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQHNSN-AKRLNVPMTLEDFTKNLRGL 807
            ...||.|||..:.:.|.:..::.|.|..|..|:::||.|.|..| .||    ||..||..||.||
Mouse   626 RERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKR----MTCGDFIGNLEGL 686

  Fly   808 NGGEDFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEI 872
            |.|.||.:|:|..::::||||::              ||.:     |..:........|..:.::
Mouse   687 NDGGDFPRELLKALYSSIKNEKL--------------QWAI-----DEEELRRSLSELADPNPKV 732

  Fly   873 FNIVWGASLSALSFMFDKSTETGYQRTLAGFSKSAAISAH----YNLHSDFDALVLTLCKFT--- 930
            ...|.|.|.|:.|...|.:.|.|           ||:..|    ..:|:|.|      |:.|
Mouse   733 IKRVSGGSGSSSSPFLDLTPEPG-----------AAVYKHGALVRKVHADPD------CRKTPRG 780

  Fly   931 --------------TLLSSVEQHEPAPANNETQQ----AVNFGLNGKAQAAMR---TVFLLVHDY 974
                          .|....|:::|..|.:|.:.    :::..|..:|....:   ..:|...|:
Mouse   781 KRGWKSFHGILKGMILYLQKEEYQPGKALSEAELKNAISIHHALATRASDYSKRPHVFYLRTADW 845

  Fly   975 GDCL--------RESWKHILDLYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEKPREKQESGLF 1031
            ...|        .:||...:::...:|.....|.::...:.|           .:|       |.
Mouse   846 RVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKF-----------SRP-------LL 892

  Fly  1032 SSLYSFISSEGQREPTYE-----------EQDFIKLGRKCIKECQLDQMLQESKFVQLE 1079
            .|..:.:|.|.|.. |:|           |.....||:|. :..:.|:..|:..:::.|
Mouse   893 PSAATRLSQEEQVR-THEAKLKAMASELREHRAAHLGKKA-RGKEADEQRQKEAYLEFE 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	159/772 (21%)
		Sec7_N	370..512	CDD:289549	24/147 (16%)
		Sec7	643..830	CDD:279680	62/187 (33%)
Psd	NP_001334383.1	PHA03247	<17..426	CDD:223021	39/206 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..96
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..195
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..277		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..401		22/119 (18%)
		Sec7	543..709	CDD:238100	65/203 (32%)
		PH_EFA6	754..878	CDD:270107	22/140 (16%)
		DUF812	<891..980	CDD:368550	14/61 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	977..1025
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900