DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment garz and Cyth4

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_082471.2	Gene:	Cyth4 / 72318	MGIID:	2441702	Length:	393	Species:	Mus musculus

Alignment Length:	205	Identity:	75/205 - (36%)
Similarity:	119/205 - (58%)	Gaps:	5/205 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   634 SEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIGEY 698
            |.:.:::.||::.:..|.::||..|.||||||.||.:|.:  |...:|.||.:..||:|..||.|
Mouse    52 STEESRMAQKEKEMCIGRKKFNMDPNKGIQYLIEHKLLTS--DVQDIAQFLYKGDGLNKTAIGTY 114

  Fly   699 ISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQDPF 763
            :.:|..::.::|..|||..:|..|.:.||||.:|.:|||||||..|..::|.|:..:...|...|
Mouse   115 LGEKDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAARYCLCNPGVF 179

  Fly   764 ANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNE 828
            .:.|..:.|::::||||...||.|.:  :.| ..|.|....||:|.|.|..:|.|..:|::||:|
Mouse   180 RSTDTCYVLSFSVIMLNTGLHNPNVR--DRP-PFERFVTMNRGINSGSDLPEEQLRNLFDSIKSE 241

  Fly   829 EIVMPAEQTG 838
            ...:|.:..|
Mouse   242 PFSIPEDDGG 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	75/205 (37%)
		Sec7_N	370..512	CDD:289549
		Sec7	643..830	CDD:279680	71/186 (38%)
Cyth4	NP_082471.2	Sec7	61..243	CDD:279680	71/186 (38%)
		PH_GRP1-like	258..376	CDD:269954
		PH	262..374	CDD:278594
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250	268..275
		C-terminal autoinhibitory region. /evidence=ECO:0000250	386..393
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810