Protein Alignment garz and Mon2

DIOPT Version :9

• Sequence 1: NP_610761.2
• Gene: garz / 36337
• FlyBaseID: FBgn0264560
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_011241835.1
• Gene: Mon2 / 67074
• MGIID: 1914324
• Length: 1716
• Species: Mus musculus
• Alignment Length: 1941
• Identity: 317/1941 - (16%)
• Similarity: 591/1941 - (30%)
• Gaps: 739/1941 - (38%)

  Fly    69 PFLEVIRTADATGPLTSLALASVNKLLSYGLIDPTSP-NLADIVERIADAVTHARFMGTDQSSDG 132
            |||....|.:.  .:|.|.||::.:|:|:.::..|:. |:.:::.::           .:.|.:.
Mouse    70 PFLMGCGTKEP--KITQLCLAAIQRLMSHEVVSETAAGNIINMLWQL-----------MENSLEE 121

  Fly   133 VTFMRVIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMR 197
            :..::.:.||.|     ....|.:.::.:.::.||::.|..  ..:...:|..:::.:|.:.|.|
Mouse   122 LKLLQTVLVLLT-----TNTVVHDEALSKAIVLCFRLHFTK--DNITNNTAAATVRQVVTVVFER 179

  Fly   198 LPQFAEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRKSSAVEEPPQTPQSANLTVPG 262
            :....:...|.                                       |||         ||
Mouse   180 MVAEDDRHRDI---------------------------------------EPP---------VP- 195

  Fly   263 HLKAPILATTPASPAGNILDMQGKITQTPTTTASTGEDETTVPETPVIQVESTESEPLLDGETGE 327
                                :||...:...:|......:..:....:.|:.:.::...|.|.| |
Mouse   196 --------------------IQGNSNRRSVSTLRPCAKDAYMLFQDLCQLVNADAPYWLVGMT-E 239

  Fly   328 ATSTLAEANSSEYINSVGVRFTQQSTDHDVTSLSPYGLPFIQELFRFLIILCNPLDKQNSDSMMH 392
            .|.|.    ..|.:.||...|.|....|             || |.||:       |:.
Mouse   240 MTRTF----GLELLESVLNDFPQVFLQH-------------QE-FSFLL-------KER------ 273

  Fly   393 TGLSLLTVAFEVAADNIGKYEGL--------LELVKDDLCRNLISLLSSERLSIFAADLQLCFLL 449
                :..:..::.:.||...:|.        :|.....:|..|:.::|               :|
Mouse   274 ----VCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVS---------------VL 319

  Fly   450 FESLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYC 514
            .:.....|..:.|.:|..|.:.:.||.|:.   :|.:|::::.:|...|..:.....:||...:.
Mouse   320 IKQFYSLLVTECEIFLSLLVKFLDSDKPQW---LRAVAVESIHRLCVQPQLLRSFCQSYDMKQHS 381

  Fly   515 TDMFESLTNLLSKYTLSATNAVYSTHIISMDTLLSVIDSIERNCAASKNSSNNRESLPEAAPATG 579
            |.:|..:.|.|..:       :.|..::..          ..|.|.:..:.||....|.:|||
Mouse   382 TKVFRDIVNALGSF-------IQSLFLVPP----------TGNPATANQAGNNNAGGPASAPA-- 427

  Fly   580 GSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINASSHRLRLQSGGEGVGITSEQLAKVKQKK 644
                   |||:.|:                                   |.|:|
Mouse   428 -------NSGVVGV-----------------------------------GGGVT----------- 439

  Fly   645 RLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIGEYISKKKNVDSKI 709
                                                                             
Mouse   440 ----------------------------------------------------------------- 439

  Fly   710 LINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFL-VLEHFSDHWHKQNQDPFANVDAAFRLA 773
               .:.:|::.|..:.      :.|..:.|.|...:| :|:        :.:.|......|..:|
Mouse   440 ---LLPAFEYRGAWIP------ILTVTVQGSAKATYLEMLD--------KVEPPTIPEGYAMSVA 487

  Fly   774 YAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPAEQTG 838
            :..::                    |..:.:..:..||      |.:|       |...|:...|
Mouse   488 FHCLL--------------------DLVRGITTMIEGE------LGEV-------EAEGPSVTEG 519

  Fly   839 LVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFNIVWGASLSALSFMFDKST-ETGYQRTLAG 902
            ...::.:.:......|..|.. ..|..|.:: |:.:..|...|:|||.:.|.|| |...:..|..
Mouse   520 ASSQSSERRDEQAASDPMDQE-TAVSRAVWE-EMVSACWCGLLAALSLLLDASTDEAATENILKA 582

  Fly   903 FSKSAAISAHYNLHSDFDALVLTLCKFT-------TLLS------------SVEQHEP---APAN 945
            ....||:.....|.:..||.:..:||.:       |:|:            |::....   :|::
Mouse   583 ELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNATTAATLSNKSYSIQGQSVMMISPSS 647

  Fly   946 NETQQAVNFG------------LNGKAQAAMRTVFLLVHDYGDCLRESWKHIL-DLYLQLFRLKL 997
            ...||.|..|            |..|....|||:..|.|.:|..|..||:.:| .|...::.|.|
Mouse   648 ESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGL 712

  Fly   998 LPKSLIEVEDFCEANGKAM---LILEKPREKQESGLFSSLYSFISSEGQREPTYEEQDFIKLGRK 1059
            .|.|           |.|:   ..:|.|.....:.:.:.| ..||:
Mouse   713 KPSS-----------GGALKPGRAVEGPSTVLTTAVMTDL-PVISN------------------- 746

  Fly  1060 CIKECQLDQMLQESKFVQLESLQELLK--CVLALLKAPQGHKSIGLPYA--EDQTVFWMEFLVKI 1120
                 .|.::.:.|:::...||..|:.  |.|:|       :::.:.|.  ::.::|.:..|::.
Mouse   747 -----ILSRLFESSQYLDDVSLHHLINALCSLSL-------EAMDMAYGNNKEPSLFAVAKLLET 799

  Fly  1121 VVHNRDRMIPLWPAVRDQMYLLLMGSASCGYDYLLNR-----CIVAVLKLAIY------LMRNEE 1174
            .:.|..|:..||..:...:.     ...|.:.....|     .:.::::..:.      |.:|:.
Mouse   800 GLVNMHRIEILWRPLTGHLL-----EKVCQHPNSRMREWGAEALTSLIRAGLTFSHEPPLPQNQR 859

  Fly  1175 LCPIVLQSLKMLLMLK-PALLLRISKQISIGIYELLKTSAQNIHSEQDWQIIFNLLECV----GA 1234
            |..::|..||.:..:. |.:.|   ||:.. :.::|::...::  ...|.::..::..:    |.
Mouse   860 LQLLLLNPLKEMSNINHPDIRL---KQLEC-VLQILQSQGDSL--GPGWPLVLGVMGAIRNDQGE 918

  Fly  1235 GAVPPNYDDAQ------LPLPP---------------------NGSAKSDGAISGEEDATAVPER 1272
            ..:...:...|      ||..|                     |.|..|.|.:....|...  :|
Mouse   919 SLIRTAFQCLQLVVTDFLPTMPCSCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFF--QR 981

  Fly  1273 GYTSDSEITKASAA--------------PAVSSPSAE-NWILVNNKDSELTTASRPQSPPSLSAP 1322
            |.|.:.|:.|..||              |...:|..: .|:.:..|..||....||....|....
Mouse   982 GETIEKELNKEEAAQQKQAEEKGVSLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQT 1046

  Fly  1323 PVNTLVYNCQLLDHAPFALFKCWDSLAFIVRSVAHITPYNFEACVRCIRIFVEACRDGGIRQRRK 1387
            ..:|:..:..||.|:      .|.::  |.:.:.|:..                      |.|..
Mouse  1047 LFSTIGAHGTLLQHS------TWHTV--IWKVLFHLLD----------------------RVRES 1081

  Fly  1388 LESAAKQKSSKKRSERKPGMASSASSSNLTLLTGDPSDNQINGNAAEQEDLAQRYEQLSIQLLDL 1452
            ..:|.|:|             ..:...|:.:              ....|.|::      |..:.
Mouse  1082 STTADKEK-------------IESGGGNILI--------------HHSRDTAEK------QWAET 1113

  Fly  1453 MYTLYTRTAQIF---RWWAEEGCTVPQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQR 1514
            ........|:||   |:       :.|....:|..|..||..|...|:.:..||...|:...|:
Mouse  1114 WVLTLAGVARIFNTRRY-------LLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQE- 1170

  Fly  1515 ALLVHDLQTLSGTEWCSCFHQVLFPLLNELLPESNAA--------GQLDAALLEESRIRTATIMS 1571
                              ..|::.|:.:...||..|.        |.|....|....:||.:|..
Mouse  1171 ------------------ILQIVSPVRDSEKPEPPAVSVPVPVLLGNLSGPGLSRPFVRTDSIGE 1217

  Fly  1572 KVFLQHLTTLIELGNAFNELWLDILDYIERFMKVGSDT--LSEQMQEILKNMLLVMHSVRVFHNQ 1634
            |           ||                  :.||:|  ::::::::
Mouse  1218 K-----------LG------------------RCGSETPVVTDELEDL----------------- 1236

  Fly  1635 DGSLQQALWELTWRRIGEFLPNLKEELFHDEGKRAQTLTNPAPQAAVAAAPQQQLPAVTILPRQT 1699
              .|..|.|. ||.|.|                            :.:..|...:..:|.:|.|
Mouse  1237 --KLWWAAWN-TWHRTG----------------------------SESTEPPSSVDELTFIPSQ- 1269

  Fly  1700 QVSNELVVSAPTPPAATPLLG-------------SPVESPRRSIILQPPMADVLQQPPSFVFAQP 1751
                         |..|.|:.             |..:..:..:||...::     .|....|.|
Mouse  1270 -------------PFLTALVQIFPALYQHIKAGFSMADLQKLGVILHSAVS-----VPISSDASP 1316

  Fly  1752 IIVPPQPPAVTDPIPPSTLLPDLVNEATAAAVQATTTSPTHSPQEAEQPASIVQQTNIVTTNNTY 1816
            .|:|....||.      |.|.:.|..|.....:|....|.:  .:...||...|....|
Mouse  1317 FILPSYTEAVL------TSLQEAVLTALDVLQKAICVGPEN--MQIMYPAIFDQLLAFV------ 1367

  Fly  1817 NSYAIEVPMAPETTAEQFGQQQQQLLYQQYYQQYQAQQQQLPAPASDPAIN-VPIS 1871
             .::.:.|        |:||.:.:.:....|.|.     ||.|||...|:| ||.:
Mouse  1368 -EFSCKPP--------QYGQLETKHIANAKYNQI-----QLFAPAEWVALNYVPFA 1409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	122/763 (16%)
		Sec7_N	370..512	CDD:289549	26/149 (17%)
		Sec7	643..830	CDD:279680	15/187 (8%)
Mon2	XP_011241835.1	DCB	9..180	CDD:374438	23/129 (18%)
		Sec7_N	211..378	CDD:372313	40/220 (18%)
		DUF1981	<871..930	CDD:370432	7/64 (11%)
		Mon2_C	933..1707	CDD:374431	121/692 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900