DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and gbf1

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_009305378.1	Gene:	gbf1 / 566350	ZFINID:	ZDB-GENE-081107-54	Length:	1862	Species:	Danio rerio

Alignment Length:	1914	Identity:	835/1914 - (43%)
Similarity:	1140/1914 - (59%)	Gaps:	211/1914 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IYVVRGEMATLMTAMRRGTRWNATAYVDDENDSLLKLFIDLKHELNRIEDLRQIEPQVFLAPFLE 72
            ||:|:||::.::.|::|.:||:....:|:|.|:||..|..||..||.|:||..:||.|||.||||
Zfish     6 IYIVQGEISVVVAAIKRNSRWSTHTPLDEEQDTLLNSFRLLKERLNNIKDLSDVEPNVFLRPFLE 70

  Fly    73 VIRTADATGPLTSLALASVNKLLSYGLIDPTSPNLADIVERIADAVTHARFMGTDQSSDGVTFMR 137
            |:|:.|.|||:|.|||.||||.|||||||......|:.:|.:|||||||||:|||.:||.|..|:
Zfish    71 VVRSEDTTGPITGLALTSVNKFLSYGLIDANHEGAAECIENMADAVTHARFVGTDPASDEVVLMK 135

  Fly   138 VIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMRLPQFA 202
            :::||.||:.:|.||.::|.|:||:|.|||:|.||.|||||||:|||.:|.|||.|.|.|||||.
Zfish   136 ILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFSRLPQFK 200

  Fly   203 EERSD---TMLQKRFTI--------GDAASGATQEKLKRKTVAQAQTAP----RKSSAVEEPPQT 252
            ||...   |.::|.:.|        ....:|...|..|.|...::...|    |..|...:|.|:
Zfish   201 EEAKSYVGTNMKKAYNILWKNKRVQLKMRAGGMSESSKWKKQKRSPRPPRHMVRSPSGQMDPAQS 265

  Fly   253 PQSAN----------------LTVPGHLKAPILATTPASPAGNILDMQGKIT-QTPTTTASTGED 300
            ....|                .|.||...|....::|.:.:|  ||...|.| :...|.......
Zfish   266 STLTNNLSGGVPFIEQHSGGSSTFPGSDSAASSISSPTTDSG--LDTGSKTTSKEDLTDLDQNSS 328

  Fly   301 ETTVPETPVIQ------------VESTES-------EPLLDGETGEATSTLAEANSSEYINSVGV 346
            ..|.|.||..:            ||..:|       |.|.|.:.....|..|..:..:|:|..||
Zfish   329 TATTPITPSAEPGRLESQSEGRGVERAQSASVESIPEVLEDRDLLADQSDSASVHDMDYVNPRGV 393

  Fly   347 RFTQQSTDHDVTSLSPYGLPFIQELFRFLIILCNPLDKQNSDSMMHTGLSLLTVAFEVAADNIGK 411
            ||| |||..:..:|.|||||.::|||||||.|.||.|:.|||.|||.||.||.||.|.|  :|..
Zfish   394 RFT-QSTQKEGAALIPYGLPCLRELFRFLISLTNPHDRHNSDVMMHMGLQLLNVALEAA--HIAP 455

  Fly   412 YEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEIIASDN 476
            |:.||.||||:|||:||.||..:|::::.|.:::|||||||:|.|||||||.||:||.:||.|:|
Zfish   456 YQSLLGLVKDELCRHLIQLLGVDRMNLYTASIRVCFLLFESMREHLKFQLEMYLKKLMDIITSEN 520

  Fly   477 PKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTLSATNAVYSTHI 541
            ||.||||:|:||:.::||||||.||||||||||||.||:::||.||.||||.....:..:|:||:
Zfish   521 PKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDFYCSNLFEDLTKLLSKNAFPVSGQLYTTHL 585

  Fly   542 ISMDTLLSVIDSIERNCAASKNSSNNRESLPEA-------------APATGGSRHSRHNSGLEGI 593
            :|::.||:||||.|.:|.|...:|..::...|:             :||..|..|...| |...:
Zfish   586 LSLEALLTVIDSTEAHCQAKVLNSATQQEQSESTTVGDSSVSTITDSPAETGKPHPSSN-GQNSV 649

  Fly   594 VID--------SGNSVAA--------EEKVENIASFINASSHRLRLQSGGEGVGITSEQLAKVKQ 642
            |.:        ||:.:|.        :|:.:.....|:...||.      ......|::|.::|.
Zfish   650 VSETRASCPPTSGHLMAEKMRLGRQDQEETDTGEKKISKKPHRF------SSYLPDSQELLEIKN 708

  Fly   643 KKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIGEYISKKKNVDS 707
            ||:||..|||:|||:|:||||.|||.|:|::.:|..:||.:|||||.||||||||:||.::|.|
Zfish   709 KKKLLITGTEQFNQKPKKGIQTLQEKGLLSSPMDNNEVAQWLRENPRLDKKMIGEFISDRRNTD- 772

  Fly   708 KILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQDPFANVDAAFRL 772
             :|.:||::|.|.|||:|:|||||||.||||||||:|..:||.|:|:|||.|.:||...||.|.|
Zfish   773 -LLDSFVNTFTFQGLRIDEALRLYLEAFRLPGEAPVIHRLLETFTDNWHKVNGNPFQTNDAGFAL 836

  Fly   773 AYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPAEQT 837
            |||:||||.||||.|.::.|:|||||.|.|||:|:|||.||||:||..::|||||||||||.|||
Zfish   837 AYAVIMLNTDQHNHNVRKQNIPMTLEQFKKNLKGVNGGNDFDQDMLEDIYNAIKNEEIVMPDEQT 901

  Fly   838 GLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFNIVWGASLSALSFMFDKS-TETGYQRTLA 901
            |||:|||.|.|||.||.:.:|.|.:|.|.|||.::|::.||.:::|||::|||| .:|..::.:|
Zfish   902 GLVKENYVWSVLLHRGASAEGMFLHVPDGSYDRDLFSMTWGPTIAALSYVFDKSLDDTIIEKAIA 966

  Fly   902 GFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNETQQAVNFGLNGKAQAAMRT 966
            ||.|.|.|||||.....||.|:::|||||||.|...::.|..          ||.|.|||.|.:|
Zfish   967 GFRKCAMISAHYGFSDVFDNLIISLCKFTTLSSESVENLPTV----------FGSNRKAQVAAKT 1021

  Fly   967 VFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEK-PREKQESGL 1030
            ||.|.|.:||.||:.||:|:|..|||||.:||||:::|||||.:.|.|..|..|: |..:.||.:
Zfish  1022 VFSLAHRHGDILRDGWKNIMDSMLQLFRAELLPKTMVEVEDFLDPNEKISLQREETPSNRGESAV 1086

  Fly  1031 --FSSLYSFISSEGQREPTYEEQDFIKLGRKCIKECQLDQMLQESKFVQLESLQELLKCVLALLK 1093
              |.|..:.....|.|.|:.|.|:..:....|||:|..:::..||||:||||||||:|.::::..
Zfish  1087 LSFVSWLTLSEQSGLRGPSTENQEAKQAALLCIKQCDPEKLNTESKFLQLESLQELMKALISVTP 1151

  Fly  1094 APQGHKSIGLPYAEDQTVFWMEFLVKIVVHNRDRMIPLWPAVRDQMY-LLLMGSASCGYDYLLNR 1157
            ..:       .|.|:...|.:|.|::|::.||||:..:|..|||.:| |.:..:.||   :|:.|
Zfish  1152 DEE-------TYDEEDAAFCLEMLLRIILENRDRVSCVWQTVRDHLYQLCVHANESC---FLVER 1206

  Fly  1158 CIVAVLKLAIYLMRNEELCPIVLQSLKMLLMLKPALLLRISKQISIGIYELLKTSAQNIHSEQDW 1222
            .:|.:|:|||.|:|.|::...||.||::|||:||.:|.|:|::::.|::|||||:|.||||..||
Zfish  1207 AVVGLLRLAIRLLRREDIGSQVLLSLRLLLMMKPHVLSRVSREVAYGLHELLKTNAANIHSTDDW 1271

  Fly  1223 QIIFNLLECVGAGAVPPNYDDAQLPL----PPNGS-AKSDGAISGEEDATAVPERGYTSDSEITK 1282
            ..:|:||||:|||..||    |.|..    |.|.: |:||..:|....:....:|||||||||..
Zfish  1272 YTLFSLLECIGAGIKPP----AALQFANTNPDNDTGAQSDSELSSYHQSEVSLDRGYTSDSEIYN 1332

  Fly  1283 ---ASAAPAVSSPSAENWILVNNKD-----SELTTASRPQSPPSLSAPPVNTLVYNCQLLDHAPF 1339
               .|..|..::.....|::|...|     :.:||.|:|.:.|.::...: ||..:..|  |...
Zfish  1333 EHGKSRIPRSATDVDVGWLVVGKDDLDGAKAAVTTPSKPMNHPLVNQYSL-TLGQDMGL--HDTK 1394

  Fly  1340 ALFKCWDSLAFIVRSVAHITPYNFEACVRCIRIFVEACRDGGIRQRRKLES---AAKQKSSKKRS 1401
            :|.||.|||:||||..||:||.|||.||:.||:||||..:||.|...|.:|   .:|....:|:.
Zfish  1395 SLIKCVDSLSFIVRDAAHVTPENFELCVKAIRVFVEASLNGGYRTHEKKKSHKYDSKSSRLRKKP 1459

  Fly  1402 ERKPGMASSASSSNLTLLTGDPSDNQINGNAAEQEDLAQRYE----QLSIQLLDLMYTLYTRTAQ 1462
            ..|.| ||..:.::........||::      |:|.:...|.    |:|:.|||||:||:||.|.
Zfish  1460 REKEG-ASRRTKASSQRPARSHSDDE------EEEGVPASYHTVSFQVSLDLLDLMHTLHTRAAG 1517

  Fly  1463 IFRWWAEE-------GCTV-PQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQRALLVH 1519
            |:..||||       |..: ..|..||:..|||||||:|.|..|.||:||..|::.| |||||||
Zfish  1518 IYSSWAEEQRHLEDAGKKIEADSQTLWTSCWCPLLQGMAWLCCDARRQVRMQALTYL-QRALLVH 1581

  Fly  1520 DLQTLSGTEWCSCFHQVLFPLLNELLPESNAAGQLDAALLEESRIRTATIMSKVFLQHLTTLIEL 1584
            |||||...||.|||::||||||.:||...:.|   |...:||:|:|..|::||||||||:.|:.|
Zfish  1582 DLQTLDAVEWESCFNKVLFPLLTKLLENISPA---DVGGMEETRMRACTLLSKVFLQHLSPLLSL 1643

  Fly  1585 GNAFNELWLDILDYIERFMKVG-SDTLSEQMQEILKNMLLVMHSVRVFHNQDGSLQQA-LWELTW 1647
             ..|..|||.|||:::::|..| ||.|.|.:.|.||||||||.:..:||:.|.....: |||:||
Zfish  1644 -PTFAALWLTILDFMDKYMHAGSSDLLLEAIPESLKNMLLVMDTAGIFHSADSRTGYSDLWEITW 1707

  Fly  1648 RRIGEFLPNLKEELFHDE--------------------GKRAQTLTNPAPQAAVAAAPQ------ 1686
            .||..|||.||||||...                    ...|.|:..|:|..|..|.|.
Zfish  1708 ERIVCFLPRLKEELFKQAVIPEPVCNVPVEPVPPPVAVPPAAPTVPAPSPVPAAPAEPNIPSRPS 1772

  Fly  1687 --QQLPAVTILPRQTQVSNELVVSAPTPPAATPLLGSPVESP----RRSIILQPPMADVLQ--QP 1743
              |.:|..:....:|..|:.  |...|||..||...||.|||    :..:||| |:|..||  .|
Zfish  1773 SPQDMPTPSANGDRTDRSSP--VPPSTPPLPTPAKKSPPESPPPLSQSPLILQ-PLASPLQVGVP 1834

  Fly  1744 PSFVFAQPIIVPPQPPAVTDPIPPSTLLP 1772
            |   ...|||:.|.....|.|:|   |||
Zfish  1835 P---MTLPIILNPALIEATSPVP---LLP 1857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	373/748 (50%)
		Sec7_N	370..512	CDD:289549	91/141 (65%)
		Sec7	643..830	CDD:279680	117/186 (63%)
gbf1	XP_009305378.1	Sec7_N	410..555	CDD:289549	93/146 (64%)
		COG5307	493..>1170	CDD:227623	336/702 (48%)
		Sec7	709..894	CDD:279680	117/186 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582816
Domainoid	1	1.000	641	1.000	Domainoid score	I157
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37897
Inparanoid	1	1.050	1354	1.000	Inparanoid score	I130
OMA	1	1.010	-	-		QHG55524
OrthoDB	1	1.010	-	-		D49474at33208
OrthoFinder	1	1.000	-	-		FOG0003083
OrthoInspector	1	1.000	-	-		oto39280
orthoMCL	1	0.900	-	-		OOG6_102130
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2055
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770