DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and psd3l

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_021334922.1	Gene:	psd3l / 559329	ZFINID:	ZDB-GENE-030131-8195	Length:	1135	Species:	Danio rerio

Alignment Length:	1233	Identity:	250/1233 - (20%)
Similarity:	402/1233 - (32%)	Gaps:	406/1233 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 NRIEDLRQIEPQVFLAPFLE-----------------------VIRTADAT---------GPLTS 85
            ||..:.|:.|...||:..:|                       .:..||.|         ....:
Zfish    87 NRANESRRPERMSFLSAVIERTSKLYGDTYTPGLHLSSSGETPAMENADVTSFPDVKGGEASAKT 151

  Fly    86 LALASVNKLLSYGLIDPTSPNLADIVERIADAVTHARFMG------------TDQSSDGVTFMRV 138
            ...|:...::....:.|..|...:..:|::.:.|||..:.            ...|||.||
Zfish   152 QCFATQTAMMPSARLRPAVPVKGEAFDRVSSSSTHAEIVAKAKYEFLFGKAEDSSSSDSVT---- 212

  Fly   139 IEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMRLPQFAE 203
                     ||..|.....|:.:..|....|.......|:     ::.|.:::.....|....|.
Zfish   213 ---------SPPQAKEKGSSILDSTLDDDDIDETSLFQEI-----DRELSNLLSGLTARSQHAAT 263

  Fly   204 ERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRK-------------------------- 242
            |:           |..:..||...: .....|.||.|.:
Zfish   264 EQ-----------GSLSGDATASPM-IPCNGQNQTLPSQLEMANQGLDLQNGQSELTGDSLLTSG 316

  Fly   243 -------SSAVEEPPQTPQSANL-------TVPGHLKAPILATTPA----SPAGNIL-------D 282
                   .:.:::|.....:||.       ..|..|.|   :.|||    .|:|.:|       :
Zfish   317 LLFDSWCEALIKDPSSVMAAANELSCFSTGNAPDKLDA---SPTPAGAHVEPSGEVLSQENSGKE 378

  Fly   283 MQGKITQTPT-----------TTASTGEDETTVPETPVI-------------------QVESTES 317
            .:||.|.:|:           ...|..|....:.|.|.|                   .||| .:
Zfish   379 TEGKRTGSPSPIRTDEPSAEIVDESLEESNKILAEVPGIFSGFLEGGKLRDKPPKKLRFVES-RA 442

  Fly   318 EPLLDGETGEATSTLAEANSSEYINSVGVRFTQQSTDHDVTSLSPYGLPFIQELFRFLIILCNPL 382
            |.|::||.         .|.|....||....||     |:.|.:..|:|....|        .|.
Zfish   443 ESLVNGEM---------QNGSHQSCSVKEEVTQ-----DIQSTAAAGVPQGSVL--------RPE 485

  Fly   383 DK--QNSDSMMHTGLSLLTVAFEVAADNI--GKYEGLLELVKDDLCRNLISLLSSERLSIFAADL 443
            .|  :|.......|.|   .|.|:...::  .::|.:||               |||
Zfish   486 QKPTENGTDRCSAGKS---AAGEIDTTDVFSCQFENILE---------------SER-------- 524

  Fly   444 QLCFLLFESLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINY 508
                     |||.|...::: |..||..:....|::..|               |.|.
Zfish   525 ---------LRGTLYSSMDS-LDALSNPVPEPTPQSTLE---------------PSFA------- 557

  Fly   509 DCDLYCTDMFESLTNLLSKYTLSATNAVYS-THIISM-------DTLLSVIDSI-----ERNCAA 560
             .|:..|.|.:......|.:...|...:.| |.::|:       .|.|.|..|.     :.:|||
Zfish   558 -FDIPLTPMIQQRLKDRSLFLEPAAPDLSSDTEVLSVTSTKERGKTALEVTSSFLSAGCKDSCAA 621

  Fly   561 SKNSSNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINASSHRLRLQS 625
            ..|..|.|:      |..........::||:.::.|..:.:...|.:::.....|
Zfish   622 LANGLNERD------PKDWLQGCLSSDAGLKDVLSDWDSDMDVVECLKDTDVLHN---------- 670

  Fly   626 GGEGVGITSEQLAKVKQKKRLLS-QGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPG 689
                 |..|:|.|..:..:||.. :|..|                        ..||..|.:|..
Zfish   671 -----GSRSDQEAARRLARRLYHLEGFRR------------------------SDVAKHLGKNND 706

  Fly   690 LDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDH 754
            ..|.:..||::               .|:||...:||:||.:|:.|.|.||......||.|||:.
Zfish   707 FSKMVAEEYLT---------------FFEFTDQTLDQSLRCFLKAFSLMGETQERERVLIHFSNR 756

  Fly   755 WHKQNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLA 819
            :::.|.......|....|..|:::||.|.|..|   :...||.::|..||.|||||:||.:|:|.
Zfish   757 YYQCNPTIITAQDGVHCLTCALMLLNTDLHGPN---IGKKMTCQEFINNLDGLNGGQDFPRELLK 818

  Fly   820 QVFNAIKNEEIVMPAEQTGLVRENYQW--------KVLLRRGDTHDGHFHYVHDASYDVEIFNIV 876
            .::|:||||::              :|        |.|....|.:    |:.|..|    |..|.
Zfish   819 SLYNSIKNEKL--------------EWAVDGDELKKSLSELADKN----HHSHSKS----ISRIS 861

  Fly   877 WGASLSALSFMFDKST---ETGYQRTLAGFSKSAAISAHYNLHSDFDA-----------LVLTLC 927
            .|:: ..|....|.:.   :||:   ||           ..:|:|.|.           ....:.
Zfish   862 SGSN-PFLDIAHDPNAAVYKTGF---LA-----------RKIHADMDGKKTPRGKRGWKTFYAVL 911

  Fly   928 KFTTLLSSVEQHEPAPANNETQQ----AVNFGLNGKA------------QAAMRTVFLLVHDYGD 976
            |...|....::::|..|.:|...    :|:..|..||            :.|...|||......:
Zfish   912 KGMILYLQKDEYKPEKALSEDDLKNAISVHHALAIKAMDYEKKPNVLKLKTADWRVFLFQAQSPE 976

  Fly   977 CLRESWKHILDLYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEKPREKQESGLFS--SLYSFIS 1039
            .: |||..|::....:|.....|.::...:.|    .:.:|.....|..||..|.|  :....:|
Zfish   977 EM-ESWIRIINSVAAMFSAPSFPAAIGSQKKF----SRPLLPATTTRMSQEEQLKSHEAKLKHVS 1036

  Fly  1040 SEGQREPTYEEQDFIKLGRKCIKECQLDQMLQESKFVQLESLQELLK-CVLALLKAPQGHKSI 1101
            :|.....:|.....:|  .|.|.|.:|.:...|.:..:.|...:||| .|..||.|..|..::
Zfish  1037 TELAEHRSYPPDKKVK--AKEIDEYRLKEHYLEFEENRYEMYVKLLKEGVKELLTAKDGDAAL 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	165/773 (21%)
		Sec7_N	370..512	CDD:289549	25/145 (17%)
		Sec7	643..830	CDD:279680	56/187 (30%)
psd3l	XP_021334922.1	Sec7	675..829	CDD:238100	58/195 (30%)
psd3l	XP_021334922.1	PH_EFA6	873..998	CDD:270107	26/139 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582787
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930