DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and IQSEC3

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_001164209.1	Gene:	IQSEC3 / 440073	HGNCID:	29193	Length:	1182	Species:	Homo sapiens

Alignment Length:	1192	Identity:	254/1192 - (21%)
Similarity:	398/1192 - (33%)	Gaps:	422/1192 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 RLSELLRR----SAE-KSLKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAASGATQEKLK---R 230
            |:.||.||    ||| :||.:...|...:.|......|...|........||:...||.|:   :
Human    35 RIDELERRLDELSAENRSLWEHQQLLQAQPPPGLVPPSSAPLPAAPATAPAAAARAQEPLQDQGQ 99

  Fly   231 KTVAQAQTAPRK------SSAVEEPPQTPQSANLTVPGHLKAPILATTPASPAGNILDMQGKIT- 288
            ::.|....||.:      ...:|:|.:.|.|.             |.||.||..: |..||.:|
Human   100 RSAAAPHPAPDRPPRQHHGQLLEQPQRGPGSR-------------AHTPQSPHKH-LGTQGAVTD 150

  Fly   289 ----QTPTTTASTG--------------------EDETTVPE----------------------- 306
                :.|:..|:.|                    |:||.:.:
Human   151 KEKERPPSCCAAAGALLQHKSPSALGKGVLSRRPENETVLHQFCCPAADACSDLASQSDGSCTQA 215

  Fly   307 ----------------------TPVIQVESTESE--------------PLLDGETGEATSTLAEA 335
                                  .|..|.:..:.|              |......|.....||.|
Human   216 GGGMEDSVVAAAAVAAGRPSAHAPKAQAQELQEEEERPGAGAASPRAGPQHKASPGRQQPALATA 280

  Fly   336 ------NSSEYINSVGVRFTQ-QSTDHDVTS--LSPYGLPFIQELFRFLIILCNPLDKQNS--DS 389
                  .:|:|..|:.::..| :..:|....  :|......||..||...:..|....:||  :|
Human   281 LCPHAPAASDYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLES 345

  Fly   390 MMHTGLSLLTVAFEVAADNIGKYEGLLE---LVKDDLCRNLISLLSSERLSIFAADLQLCFLLFE 451
            .:...:||..|. ...|:::...:.|:|   ||...|.|      |......||..|       .
Human   346 RLPRRISLRKVR-SPTAESLAAEKALMEGYGLVGLPLVR------SPSLPPTFAGTL-------T 396

  Fly   452 SLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRI----PGFVTE--------- 503
            .|......|:::..:.:.:.:::.:.||...:||.....|.|..:.    ||...|
Human   397 ELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGP 461

  Fly   504 -----------LYINYDCDLYCTDMFESLTNLLSKYTLSATNAVYSTHIISMDTLLSVIDSIERN 557
                       |...:...|...  |..:|..::...:|          :|..|.|||     .|
Human   462 GPGDDAAETPGLPPAHSGTLMMA--FRDVTVQIANQNIS----------VSSSTALSV-----AN 509

  Fly   558 C---------------AASKNSSNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAA---- 603
            |               .|.:..::.||: || |||.|....|..:|..|.....:.:...|
Human   510 CLGAQTVQAPAEPAAGKAEQGETSGREA-PE-APAVGREDASAEDSCAEAAASGAADGATAPKTE 572

  Fly   604 -EEKVENIA--------------SFINASSHRLRLQSGGEGVGITS----------------EQL 637
             ||:.|..|              ...::|:.....:||.|.....|                |..
Human   573 EEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENP 637

  Fly   638 AKVKQ--------KKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKM 694
            |..|.        :|||...|...||..|:||||:|...|.:..  .|:.||.||.:..||.::|
Human   638 ASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPD--TPIGVAHFLLQRKGLSRQM 700

  Fly   695 IGEYI-SKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQ 758
            |||:: :.||..:..:|...||..||:.:.:|:|||.:....|:.|||..:..::|.||..:...
Human   701 IGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMC 765

  Fly   759 NQD---PFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQ 820
            |.:   .|.|.|..|.||:|||:||.|.::.|.|. :..|.||||.:||||::.|.|..:|::..
Human   766 NPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKP-DRKMMLEDFIRNLRGVDDGADIPRELVVG 829

  Fly   821 VFNAIKNEEIVMPAEQTGLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFNIVWGASLSALS 885
            ::..|:.:|:                       .:::.|..||
Human   830 IYERIQQKEL-----------------------KSNEDHVTYV---------------------- 849

  Fly   886 FMFDKSTETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNETQQ 950
                    |..::::.|. |:.....|..         |..|.....::.|         |:.|
Human   850 --------TKVEKSIVGM-KTVLSVPHRR---------LVCCSRLFEVTDV---------NKLQ- 886

  Fly   951 AVNFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIEVEDFCEANGKA 1015
                    |..|..|.|||    :.|.              |..|||.|
Human   887 --------KQAAHQREVFL----FNDL--------------LVILKLCP---------------- 909

  Fly  1016 MLILEKPREKQESGLFSSLYSFISSEGQREPTYE--EQDFIKLG------------RKCIKECQL 1066
                     |::|   ||.|:|..|.|.....::  |.::...|            ::.:..|.|
Human   910 ---------KKKS---SSTYTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVLHFCAL 962

  Fly  1067 --DQMLQESKFVQLESLQELLKCVLAL--------LKAPQGHKSI---------------GLPYA 1106
              |:|   .|||  |.|:|.:..|..|        |:..||.|::               |.|.|
Human   963 GSDEM---QKFV--EDLKESIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSPTA 1022

  Fly  1107 EDQTVFW---MEFLVKIVVHNR 1125
            :.:....   .|..|::.:|||
Human  1023 KREAALRERPAESTVEVSIHNR 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	178/823 (22%)
		Sec7_N	370..512	CDD:289549	32/170 (19%)
		Sec7	643..830	CDD:279680	70/190 (37%)
IQSEC3	NP_001164209.1	bZIP	<32..63	CDD:269834	11/27 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..157		24/108 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..275		5/44 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..479		4/34 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..616		21/96 (22%)
		Sec7	651..839	CDD:279680	70/190 (37%)
		PH_IQSEC	866..996	CDD:270128	41/207 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1002..1090		8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1182
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148869
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740