DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and Efa6

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_001163691.2	Gene:	Efa6 / 42665	FlyBaseID:	FBgn0051158	Length:	1601	Species:	Drosophila melanogaster

Alignment Length:	843	Identity:	166/843 - (19%)
Similarity:	280/843 - (33%)	Gaps:	273/843 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 FAEERSDTMLQKRFTIGDAASGATQEK---LKRKTVAQAQTAPRKSSAVEEPPQTPQSANLTVPG 262
            :.:|.:|.. .:.::.....||:.:::   ||::|..:.|  .|...||:            ..|
  Fly   545 YDDEENDAG-DEDYSTNSLGSGSAKQRLRALKQRTATRQQ--QRNRDAVD------------CAG 594

  Fly   263 HLKAPILATTPASPAGNILDMQGKITQTPTTTASTGEDET--TVPETPVIQVESTESEPLLDGET 325
            ...:...:||..|.||.:                 |.|||  :||.:|:     :.|.||:|.||
  Fly   595 RSGSGSSSTTVKSEAGGL-----------------GLDETSFSVPTSPI-----SLSTPLIDKET 637

  Fly   326 G-------EATSTLAEANSSEYINSVGVR---------------FTQQSTDHDVTSLSPYGLPFI 368
            .       |.:|.:.|::|.....:|.||               .|.:|.||            :
  Fly   638 ANSVPTSPEPSSLVPESSSGAGAGAVVVRRHNGHVVRKCDAAGFRTSKSEDH------------L 690

  Fly   369 QELFRFLIILCNPLD-KQNSDSMMHTGL----------SLLTVAFEVAA-----------DNIGK 411
            |::.|..|....|:| .::.:|.::|.|          |:.||....::           ||...
  Fly   691 QQIQREGIAAVIPIDIDEDVNSSLNTLLDTRQDSEDSQSMATVIVNNSSLASNNNEGEQTDNRSS 755

  Fly   412 YEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSE---IIA 473
            .........::...|.....:||..:..|..:........:....|.:.|   .:|.|:   |:.
  Fly   756 SSSSNSSDNNNCSSNTGEPATSETATATATIITATSTRTMNCSSKLNYIL---CKKASDRDRIVW 817

  Fly   474 SDN-PKTPYEMRELALDNLLQLWRIPGFVTELYINY----------------------DCDLYCT 515
            :.| |..|:::..|......|..:......:|:..:                      ...||..
  Fly   818 TYNAPLQPHQLAALQRQQQQQEQQFQQQQQQLHQQHLQQQQQLQQQHQQQQQQQQQQQQQQLYGQ 882

  Fly   516 DMFES--LTNLLSKYTLSATNAVYSTHIISMDTLLSVIDSIERNCAASKNSSNN----------- 567
            ....:  .:::.|....||..:..|...:|.    ||:.|.....|....||:|
  Fly   883 QSHSNSHSSSISSSPQHSAVGSPASPTSVSS----SVMSSSGSKGALGLGSSSNGPMAAVQQQQL 943

  Fly   568 --RE----------SLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIAS-------- 612
              ||          .:|......||.  ..:|.|..||.....|..:..|.:.||:|
  Fly   944 REREQGGQVAQPPSGIPGLLSCPGGG--CGNNGGGGGIGGGGNNDQSVSEAISNISSPDYQDDDN 1006

  Fly   613 ------------------------FINASSH-------RLRLQ---------------------- 624
                                    ..:|::|       :||.|
  Fly  1007 LLSSRDILGGMVLSDPSDSDSTILVSDAAAHQRQQLKQQLRAQQQQQRERERDRDRDREQSEHKV 1071

  Fly   625 -----------SGGEG---------VGITSEQLAKVKQKKR-----LLSQGTERFNQRPEKGIQY 664
                       |||.|         |.:|.|.|..:....|     :...|::         ::.
  Fly  1072 VIQVRGLDSNSSGGNGTNGRSEEDVVTLTDEPLGTMTVGMRDASPPVSDDGSD---------VES 1127

  Fly   665 LQEHGILNAELD---PMQVALFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQ 726
            |..:......:|   .:::|..|....|..|..:..::||..:....:...::..|.|....:||
  Fly  1128 LHSYHYSPKAVDMPSAIRLAKRLHSLDGFKKSDVSRHLSKNNDFSRAVADEYLKHFTFEKKSLDQ 1192

  Fly   727 ALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRL 791
            |||.:|:.|.|.||......||.|||..:...|...|.:.||...|..||::||.|.|..|   :
  Fly  1193 ALREFLQQFSLSGETQERERVLVHFSKRFLDCNPGTFNSQDAVHTLTCAIMLLNTDLHGQN---I 1254

  Fly   792 NVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENYQWKVLLRRGD 854
            |..|:..:|..||..||.||:|.:::|..::.|||.:.:              :|.:....||
  Fly  1255 NRKMSCAEFVDNLADLNDGENFPKDVLKSLYQAIKTKPL--------------EWALDEEAGD 1303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	131/686 (19%)
		Sec7_N	370..512	CDD:289549	27/189 (14%)
		Sec7	643..830	CDD:279680	53/194 (27%)
Efa6	NP_001163691.2	PDZ_signaling	7..85	CDD:238492
		PHA03269	225..>344	CDD:165527
		Sec7	1124..1293	CDD:238100	51/180 (28%)
		PH_EFA6	1330..1452	CDD:270107
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452083
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840