Protein Alignment garz and Iqsec3

DIOPT Version :10

• Sequence 1: NP_610761.2
• Gene: garz / 36337
• FlyBaseID: FBgn0264560
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_997500.2
• Gene: Iqsec3 / 404781
• RGDID: 1593191
• Length: 1194
• Species: Rattus norvegicus
• Alignment Length: 1178
• Identity: 256/1178 - (21%)
• Similarity: 397/1178 - (33%)
• Gaps: 392/1178 - (33%)

  Fly   174 RLSELLRRSAEKSLKDMVLLFFMRLPQFAEERS----DTMLQKRFTIG---------------DA 219
            |:.||.||..|.|               ||.||    ..:||.:...|               ..
  Rat    35 RIDELERRLDELS---------------AENRSLWEHQQLLQAQPPPGLVPPPSAPLPAPAATAP 84

  Fly   220 ASGATQEKLK-----------------RKTVAQAQTAPRKSSAVEEPPQTPQSANL--TVPG--- 262
            |:.|.||.|:                 .:.:||.|.||  ||.|    |||||.:.  ..||
  Rat    85 AATAAQEPLQDHGQLIPATPEPPLQHHGQLLAQPQPAP--SSRV----QTPQSPHQHPVAPGAVA 143

  Fly   263 -------------------HLKAPIL----------------------ATTPASPA--------- 277
                               |.....|                      |.|...||
  Rat   144 DKEKERPSSCCAAAGALLQHASPAALGKGVLSRRPKNETVLHQFCCPAADTEQKPACSDLASQSD 208

  Fly   278 GNILDMQGKITQTPTTTASTGEDETTVP--ETPVIQVE--------STESEPLLDGETGEATSTL 332
            |:.....|.:..:.....:.|......|  :.|.:|.|        |..:.||.....|:....|
  Rat   209 GSCAQAGGGMEDSVVAAVAAGRPSAHAPKAQAPELQQEEERPGAVGSPRAGPLRAASPGQQQPAL 273

  Fly   333 AEA------NSSEYINSVGVRFTQ-QSTDHDVTS--LSPYGLPFIQELFRFLIILCNPLDKQNS- 387
            |.|      .:|||..|:.::..| :..:|....  :|......||..||...:..|....:||
  Rat   274 ATALCSHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSL 338

  Fly   388 -DSMMHTGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSI---FAADLQLCFL 448
             :|.:...:||..|....|...:.: :.|||     .| .|:.|......|:   ||..|
  Rat   339 LESRLPRRISLRKVRAPTAESLVAE-KALLE-----SC-GLLGLPLGRSPSLPPTFAGSL----- 391

  Fly   449 LFESLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWR----IPGFVTELYINYD 509
              ..|......|:::..:.:.:.:::.:.||...::|.....|.|...    .||..||.....|
  Rat   392 --TELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETEAAREPD 454

  Fly   510 CDLYCTDMFESLT-----NLLSKY---TLSATNAVYSTHIISMDTLLSVIDSIERNCAASKNSSN 566
            ......|...||.     .|:..:   |:...|...|   :|..|.|||     .||..::.:..
  Rat   455 SGPGSGDEAGSLPQGHSGTLMMAFRDVTVQIANQNIS---VSSSTALSV-----ANCLGAQTAQA 511

  Fly   567 NRE-----------------SLP---------EAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEE 605
            ..|                 .:|         |.:.|......|.|...:...|::...:..|||
  Rat   512 TAEPAAVQTEQGDAATQEVSEVPASELMDPPVEDSEAAESGAQSAHEPTVAEAVVEEAVATEAEE 576

  Fly   606 KVE---------------NIASFINASSHRLRLQSGGEGVGITSEQ------------------- 636
            :.|               |.....::|:.....:||.|.....|::
  Rat   577 EEEGAGQAGKGAEAEVGDNSEQLSSSSASTKSAKSGSEVSAAASKEALQAVILSLPRYHCENPAS 641

  Fly   637 -----LAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIG 696
                 |:....:|||...|...||..|:||||:|...|.:..  .|:.||.||.:..||.::|||
  Rat   642 CRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPD--TPIGVAHFLLQRKGLSRQMIG 704

  Fly   697 EYI-SKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQ 760
            |:: :.||..:..:|...||..||:.:.:|:|||.:....|:.|||..:..::|.||..:...|.
  Rat   705 EFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNP 769

  Fly   761 D---PFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVF 822
            :   .|.|.|..|.||:|||:||.|.::.|.|. :..|.||||.:||||::.|.|..:|::..::
  Rat   770 EVVQQFHNPDTIFILAFAIILLNTDMYSPNIKP-DRKMMLEDFIRNLRGVDDGADIPRELVVGIY 833

  Fly   823 NAIKNEEIVMPAEQTGLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFNIVWGASLSALSFM 887
            ..|:.:|:                       .:::.|..||
  Rat   834 ERIQQKEL-----------------------KSNEDHVTYV------------------------ 851

  Fly   888 FDKSTETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNETQQAV 952
                  |..::::.|. |:.....|..         |..|.....::.|         |:.|
  Rat   852 ------TKVEKSIVGM-KTVLSMPHRR---------LVCCSRLFEVTDV---------NKLQ--- 888

  Fly   953 NFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIE-VEDFCEANGKAM 1016
                  |..|..|.|||    :.|.              |..|||.||.... ...||:|.|
  Rat   889 ------KQAAHQREVFL----FNDL--------------LVILKLCPKKKSSFTYTFCKAVG--- 926

  Fly  1017 LILEKPREKQESGLFS---SLYSFISSEGQREPTYEEQDFIKLGRKCIKECQLDQMLQESKFVQL 1078
             :|.......|:..:|   :|.:.:|...:::..:    |..||.        |:|   .|||
  Rat   927 -LLGMRFHLFENEYYSHGITLATPLSGSEKKQVLH----FCALGS--------DEM---QKFV-- 973

  Fly  1079 ESLQELLKCVLAL--------LKAPQGHKSI---------------GLPYAEDQTVFW---MEFL 1117
            |.|:|.:..|..|        |:..||.|::               |.|.|:.:.:..   .|..
  Rat   974 EDLKESIAEVTELEQIRIEWELERQQGTKTLSARSAGAQGDPQSKQGSPTAKREAMAGEKATESS 1038

  Fly  1118 VKIVVHNR 1125
            .::.:|||
  Rat  1039 GEVSIHNR 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	PLN03076	<395..>986	CDD:215560	148/674 (22%)
		Sec7	643..830	CDD:460178	70/190 (37%)
Iqsec3	NP_997500.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..149		21/92 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	229..272		9/42 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	439..471		8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..610		12/94 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1002..1099		8/45 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1137..1175