DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and siz

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_730594.1	Gene:	siz / 40327	FlyBaseID:	FBgn0026179	Length:	1325	Species:	Drosophila melanogaster

Alignment Length:	1096	Identity:	237/1096 - (21%)
Similarity:	373/1096 - (34%)	Gaps:	346/1096 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 RVIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMRLPQF 201
            |::....:|..:.|||:.|         |.:..:.|.:|:|                      |.
  Fly   372 RMVVTASSLGLAEEGASSS---------SAYGSATESQLTE----------------------QQ 405

  Fly   202 AEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRKSSAVEEPPQ-----TPQSANLTVP 261
            .::::....|.|.||....:||....|.|       |.|.:|.::.|..|     .|:|.:...|
  Fly   406 QQQQAQQQQQPRVTIMAGPAGAASPGLSR-------TPPTRSLSMRERRQLDCSPIPRSQSGASP 463

  Fly   262 GHLKAPILATT--PASPAGNILDM------------QGKITQTP----------TTTASTGEDET 302
            ..:.:..::|:  .:.|..|:|..            ||....|.          .::|.|..:.:
  Fly   464 ASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHDLSYASSADTSLNAS 528

  Fly   303 TV------PETPVIQVE---------STESEPLLDGETGEATSTLAEANSSEYINSVGVRFTQQS 352
            .|      |.||.....         ||...|...|.||..:......:|.:....|..| |...
  Fly   529 WVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTPSCSGSTGSGSGGSGSGSSKKVPPEVPKR-TSSI 592

  Fly   353 TDHDVTSLSPYGLPFIQELFRFLIILCNPLDKQN--SDSMMHTGLSLLTVAFEVAADNIGKYEGL 415
            |....|.|                :|   |.:|.  ..|::.|
  Fly   593 TAQQQTQL----------------LL---LQRQTPPPPSLLRT---------------------- 616

  Fly   416 LELVKDDLCR-----NLISLLSS-ERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEIIAS 474
                 :.||:     :|.|:.|| ...|:.:|:                       |.|:..:.|
  Fly   617 -----NGLCKTAENGSLTSVQSSGSDSSVTSAE-----------------------RNLNSDLGS 653

  Fly   475 DNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTLSATNAVYST 539
            |...:|:            .|:                              :.|...::..:||
  Fly   654 DRSNSPH------------TWK------------------------------RGTALNSSQQFST 676

  Fly   540 HIISMDTLLSVIDSIERNCAASKNSSNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAE 604
            |  |.|:..:|..........:...:...::...||.|.||...:..::      |.|..|.|..
  Fly   677 H--SADSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHA------ISSHTSAAQY 733

  Fly   605 EKVENIASFINASSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHG 669
            |:.|      .....:.:||:.....|:..........:||....|...||::|||||.||...|
  Fly   734 EQHE------QQQHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRG 792

  Fly   670 ILNAELDPMQVALFLRENPGLDKKMIGEYISKKKN-VDSKILINFVDSFDFTGLRVDQALRLYLE 733
            .|  |..|..||.||....||.::|||||:...:| .:..:|..|....|.:|.:||.|||.:..
  Fly   793 FL--ENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQA 855

  Fly   734 TFRLPGEAPLIFLVLEHFSDHWHKQNQDPFANV---DAAFRLAYAIIMLNMDQHNSNAKRLNVP- 794
            .||:||||..|..::|.||..:.:.|.|....:   |..|.||:||||||.|.|..|.|    |
  Fly   856 YFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLK----PE 916

  Fly   795 --MTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEI---------VMPAEQTGLVRENYQWKV 848
              |.:|||.|||||::...|.|::||..:::.:|::|.         ||..:.| :|.:.....:
  Fly   917 RRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQAT-IVGKKPNLAL 980

  Fly   849 LLRR----------GDTHDGHFHYVHDASYDVEIFNIVWGASLSALSFMFD-KSTETGY----QR 898
            ..||          .|.:......||..  :|.:||     .|..::.:|. |.|...|    ..
  Fly   981 PHRRLVCYCRLYEIPDVNKKERPGVHQR--EVFLFN-----DLLVITKIFSKKKTSVTYTFRNSF 1038

  Fly   899 TLAGFSKSAAISAHY----NLHSDFDALVLTL---------CKFT----TLLSSVEQHEP--APA 944
            .|.|...:.....:|    .|....|..:|..         |||.    ..:|.:::.|.  ..|
  Fly  1039 PLCGTVVTLLDMPNYPFCIQLSQKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEA 1103

  Fly   945 NNETQQAVNFGLNGKAQ---AAMRTVFLLVHDY---GDCLRESWKHILDLYLQLFRLKLLPKSLI 1003
            ..|.|::......|.|:   :.:..|.:....|   .....|...:..|...||.| ..|..||:
  Fly  1104 ELERQKSARNRAPGNAENRDSGVADVEVCPCPYQQGSQASGEQAPNSADNSQQLKR-SALSNSLL 1167

  Fly  1004 EVEDFCEANGKAMLILEKPREK-----QESGLFSSLYSFISSEGQRE------------------ 1045
               |..|..|.     |||:.:     .:||:..|..|..:|...||
  Fly  1168 ---DMHEQFGN-----EKPQRRGSVGSLDSGMSISFQSTTTSSASRENAAAIAAAANAAAAAKMR 1224

  Fly  1046 ----PT-----------------YEEQDFIKLGRKCIKECQLDQMLQESKFVQLES 1080
                ||                 |...:|       :::.|...|||:.:.:|.::
  Fly  1225 FNMPPTAAIATPSNVYAAPGMQAYTHANF-------VQQSQAAYMLQQQQMLQQQA 1273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	184/823 (22%)
		Sec7_N	370..512	CDD:289549	19/149 (13%)
		Sec7	643..830	CDD:279680	78/193 (40%)
siz	NP_730594.1	Sec7	766..954	CDD:279680	78/193 (40%)
siz	NP_730594.1	PH_IQSEC	981..1108	CDD:270128	26/133 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452079
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840