Protein Alignment garz and Sec71

DIOPT Version :9

• Sequence 1: NP_610761.2
• Gene: garz / 36337
• FlyBaseID: FBgn0264560
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Alignment Length: 1773
• Identity: 340/1773 - (19%)
• Similarity: 619/1773 - (34%)
• Gaps: 569/1773 - (32%)

  Fly    61 IEPQVFLAPFLEVIRTADATGPLTSLALASVNKLLSYGLIDPTSPNLAD----IVERIADAVTHA 121
            |..:.:..||....::......:|  ||..:.||::||.:..:..:.|:    :::||...: :.
  Fly    77 INAETYFLPFELACKSRSPRIVVT--ALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVTI-YG 138

  Fly   122 RFMGTDQSSDGVTFMRVIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEKS 186
            .|.|  ..:|....:::|:.|.|::.| :...:...::.:.:.:|:.|....: :.:.:.:|..:
  Fly   139 CFSG--PQTDEAVQLQIIKALLTVVTS-QHVEIHEFTLLQAVRTCYDIYLSSK-NLVNQTTARAT 199

  Fly   187 LKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRKSSAVEEPPQ 251
            |..|:.:.|.|:                                           ::...|.||.
  Fly   200 LTQMLNVIFARM-------------------------------------------ENQVYELPPP 221

  Fly   252 TPQSANLTVPGHLKAPILATTPASPAGNILDMQGKITQTPTTTASTGE------DETTVPETPVI 310
            .....|.::...                  |..|           :||      ||....|....
  Fly   222 NSNPTNGSIHSE------------------DCNG-----------SGEESLRDSDEVIASELLAE 257

  Fly   311 QVESTESEPLLDGET-GEATSTLAEANSSEYINSVGVRFTQQSTDHDVTSLSPYGLPFIQELF-- 372
            .:.:..:|.:.|.|: ||...||   |.::|         ...:|||...|.......:...|
  Fly   258 IISAAYNEAMKDQESVGEPEPTL---NGNDY---------SSHSDHDSVELHSENDAVVTAKFTH 310

  Fly   373 -----RFLII--LC----NPLDKQNSDSMMH------TGLSLLTVAFEVAADNIGKYEGLLELVK 420
                 .||:.  ||    .||...:.|...|      ..|.||.:..:.|.......|..:..:|
  Fly   311 ILQKDAFLVFRALCKLSMKPLPDGHPDPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIK 375

  Fly   421 DDLC----RNLISLLSSERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEIIASDNPKTPY 481
            ..||    .|.:||:.    .:|...|.:...|..:.:.|||.|:|.:.:::...|...| .:.:
  Fly   376 QYLCVALSNNGVSLVP----EVFELSLSIFVALLSNFKVHLKRQIEVFFKEIFLNILEAN-SSSF 435

  Fly   482 EMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTLS------ATNAVY--S 538
            |.:.:.:..|.::......|.::|:|||||....::||.|.|.|||....      ..|.:.  |
  Fly   436 EHKWMVIQALTRICADAQSVVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGANPMQEKS 500

  Fly   539 THIISMDTLLSVIDSIERNCAA--SKNSSNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSV 601
            ..|..::.|:|::     .|..  ||:...|                  .|..:..:.:.|..|.
  Fly   501 MRIRGLECLVSIL-----KCMVEWSKDLYVN------------------PNMPVPPMQVQSPTST 542

  Fly   602 AAEEKVENIASFINASSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQ 666
            ..::....|.:..:.|||  .|.|..|.:....|.|.:.|.:|.::..|.|.||::|:||:|:||
  Fly   543 EQDQADTTIQTMHSGSSH--SLNSNQEQLQDLPEALEERKMRKEVMETGIELFNRKPQKGVQFLQ 605

  Fly   667 EHGILNAELDPMQVALFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLY 731
            |..:|.|...  .:|.:|.|:..|||.:||.||.:..:...:::..::|:|||..:.|..|||..
  Fly   606 EKQLLGATCG--DIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFL 668

  Fly   732 LETFRLPGEAPLIFLVLEHFSDHW---HKQNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNV 793
            ||.|||||||..|..::|.|:..:   :.:|| .|.:.|..:.||::||||..|.|:...|.
  Fly   669 LEGFRLPGEAQKIDRLMEKFASRYCECNPKNQ-LFQSADTVYVLAFSIIMLTTDLHSPQVKH--- 729

  Fly   794 PMTLEDFTKNLRGLNGGE-DFDQEMLAQVFNAIKNEEIVM-----------PAEQTGLVRE---- 842
            .||.|.:.|..||::..: |..:|.|:.:::.|...||.|           |..:...:.|
  Fly   730 KMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKNNSGMLQQAKPTGKQAFITEKRRK 794

  Fly   843 ---NYQWKVL-------------LRRGDTHDGHFHYVHDASYDVEIFNIVWGASLSALSFMFDKS 891
               |.:.:|:             ::...|...|..:|.      .:|.:.|...|:|.|
  Fly   795 LLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEHVR------PMFKMAWTPFLAAFS------ 847

  Fly   892 TETGYQ---------RTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNE 947
              .|.|         ..|.|...:..|:..:::..:.||.|..|.:||.|.::...:|....|.:
  Fly   848 --VGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLNANSPINEMKAKNID 910

  Fly   948 TQQAVNFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIEVEDFCEAN 1012
            |               ::|:.::.|..|:.|..||   ||:...:.:|:|
  Fly   911 T---------------IKTLIMVAHTDGNYLGSSW---LDIVKCISQLEL--------------- 942

  Fly  1013 GKAMLILEKPREKQESGLFSSLYSFISSEGQREPTYEEQDFIKLGRKCIKE--CQLDQMLQESKF 1075
              |.||....|.:..||..::|...::      |:.:|.    :|....:.  ..:|::...|..
  Fly   943 --AQLIGTGVRPQFLSGAQTTLKDSLN------PSVKEH----IGETSSQSVVVAVDRIFTGSMR 995

  Fly  1076 VQLESLQELLK--CVLALLKAPQGHKSIGLPYAEDQTVFWMEFLVKIVVHNRDRMIPLWPAVRDQ 1138
            :..:::.:.:|  |.:::.:..|          :...:|.::.:|:|..:|.:|:...|    .:
  Fly   996 LDGDAIVDFVKALCQVSVDELQQ----------QQPRMFSLQKIVEISYYNMERIRLQW----SR 1046

  Fly  1139 MYLLL---MGSASCGYDYLLNRCIVAVLKLAIYLMRNEELCPIVLQSLKMLLM------------ 1188
            ::.:|   ..:..|.                    .|||:....|.||:.|.|
  Fly  1047 IWQVLGEHFNAVGCN--------------------SNEEISFFALDSLRQLSMKFMEKGEFSNFR 1091

  Fly  1189 ----------------LKPALLLRISKQISIGIYELLKTSAQNIHSEQDWQIIFNLLECVGAGAV 1237
                            ..||:...:.:.|:    :::.:.|.||.|  .|:.||::.. :.||
  Fly  1092 FQKDFLRPFEHIMKKNASPAIRDMVVRCIA----QMVNSQAHNIRS--GWKNIFSIFH-LAAG-- 1147

  Fly  1238 PPNYDDAQLPLPPNGSAKSDGAISGEEDATAVPERGYTSDSEITKASAAPAVSSPSAENWILVNN 1302
                 |.:.|: ...:.::.|.|.|:
  Fly  1148 -----DNEEPI-VELAFQTTGKIIGD--------------------------------------- 1167

  Fly  1303 KDSELTTASRPQSPPSLSAPPVNTLVYNCQLLDHAPFALFKCWDSLAFIVRSVAHITPYNFEACV 1367
                                                  |:|  ...|.:|.|        |:..|
  Fly  1168 --------------------------------------LYK--RQFAIMVDS--------FQDAV 1184

  Fly  1368 RCIRIFVEACRDGGIRQRRKLESAAKQKSSKKRSERKPGMASSASSSNLTLLTGDPSDNQINGNA 1432
            :|:..|..|
  Fly  1185 KCLSEFATA-------------------------------------------------------- 1193

  Fly  1433 AEQEDLAQRYEQLSIQLLDLMYT---LYTRTAQIFRWWA--EEGCTVPQSAALWSPGWCPLLQGI 1492
                    |:...|::.:.|:.|   ......|:|...|  |...:|.:...:|..||.|:|..:
  Fly  1194 --------RFPDTSMEAIRLVRTCAQCVHEAPQLFAEHAGMENDASVAEEDRVWVRGWFPMLFSL 1250

  Fly  1493 ARLAMDRRREVRTHAISCLQQRALLVHDLQTLSGTEWCSCFHQVLFPLLNEL-LPESNAAGQLDA 1556
            :.:....:.:|||.|::.|.:   :|..........|......|:|.:.:.: |||.
  Fly  1251 SCVVNRCKLDVRTRALTVLFE---IVKTYGESFKPHWWKDLFNVIFRIFDNMKLPEH-------- 1304

  Fly  1557 ALLEESRIRTAT------IMSKVFLQHLTTL--IELGNAFNELWLDILDYIERFMKVGSDTLSEQ 1613
             :.|:|...|.|      .:..||.|:...|  :.|...|.:|...:....|:..:.|::.|..
  Fly  1305 -VTEKSEWMTTTCNHALYAIIDVFTQYFDVLGHLLLEELFAQLHWCVQQSNEQLARSGTNCLEN- 1367

  Fly  1614 MQEILKNMLLVMHSVRVFHNQ-------------DGSLQQALWELTWRRIGEFLPNLKEELFHDE 1665
                     ||:.:...|:..             :.:|.|.|  |:||.......|:.:|..|.|
  Fly  1368 ---------LVISNGFKFNESTWDKTCQCILDIFNATLPQDL--LSWRPKAHSSNNIPQEHNHFE 1421

  Fly  1666 G---------KRAQTLTN 1674
            .         :..||:.|
  Fly  1422 ALHIRCVVQLELIQTMDN 1439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	189/792 (24%)
		Sec7_N	370..512	CDD:289549	38/164 (23%)
		Sec7	643..830	CDD:279680	67/190 (35%)
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	340/1773 (19%)
		DCB	30..212	CDD:292830	27/184 (15%)
		Sec7_N	312..465	CDD:289549	36/157 (23%)
		Sec7	582..767	CDD:279680	67/190 (35%)
		DUF1981	1080..1161	CDD:286414	14/95 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452087
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850