DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment garz and Arfgef1

DIOPT Version :9

Sequence 1:NP_610761.2 Gene:garz / 36337 FlyBaseID:FBgn0264560 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_001263985.1 Gene:Arfgef1 / 312915 RGDID:1560793 Length:1846 Species:Rattus norvegicus


Alignment Length:1851 Identity:375/1851 - (20%)
Similarity:655/1851 - (35%) Gaps:537/1851 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 IEPQVFLAPFLEVIRTADATGPLTSLALASVNKLLSYGLI-----DPTSPNLADIVERIADAVTH 120
            ||...:..||  .:........:.|.:|..:.||::||.:     |.|:|. ..:::||.:.:..
  Rat    75 IEADKYFLPF--ELACQSKCPRIVSTSLDCLQKLIAYGHLTGSAPDSTTPG-KKLIDRIIETICG 136

  Fly   121 ARFMGTDQSSDGVTFMRVIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEK 185
            . |.| .|:.:||. :::|:.|.|.:.| :...:...::.:.:.:|:.|....: :.:.:.:|:.
  Rat   137 C-FQG-PQTDEGVQ-LQIIKALLTAVTS-QHIEIHEGTVLQAVRTCYNIYLASK-NLINQTTAKA 196

  Fly   186 SLKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRKSSAVEEPP 250
            :|..|:.:.|.|:...|.:.:..|.::|.        ..|..|.:..|:..:  |........||
  Rat   197 TLTQMLNVIFARMENQALQEAKQMERERH--------RQQHHLLQSPVSHHE--PESPHLRYLPP 251

  Fly   251 QTPQSANLTVPGHLKAPILATTPASPAGNILD--MQGKITQTPTTTASTGE------DETTVPET 307
            ||.........|.|          .|..:.:|  :|..|.....:..|:.|      |:.|..||
  Rat   252 QTVDHIAQEQEGDL----------DPQTHDVDKSLQDDIEPENGSDISSAENEQTEADQATAAET 306

  Fly   308 -----------------PVIQVESTESEPLLDGETGEATSTLAEA----------NSSEYINSVG 345
                             .::|....|...::.|:.||.|:..|.|          :.||.:.:.|
  Rat   307 LSKDDVLCDGECEEKPQDIVQSIVEEMVDIIVGDMGEGTAVSASADGNAGAVEDGSDSENVQANG 371

  Fly   346 V----------------RFTQQSTDHDVTSLSPYGLP-----FIQELFRFLII--LC----NPLD 383
            :                |.:..|.|...:..|....|     .|.:...||:.  ||    .||.
  Rat   372 IPGTPISAAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLS 436

  Fly   384 KQNSDSMMH------TGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSIFAAD 442
            ....|...|      ..|.||....:.|.......|..:..:|..||..|.....|....:|...
  Rat   437 DGPPDPKSHELRSKILSLQLLLSILQNAGPVFRTNEMFINAIKQYLCVALSKNGVSSVPEVFELS 501

  Fly   443 LQLCFLLFESLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYIN 507
            |.:...|..:.:.|||.|:|.:.:::...|. :...:.::.:.:.:..|.::......|.::|:|
  Rat   502 LSIFLTLLSNFKTHLKMQIEVFFKEIFLYIL-ETSTSSFDHKWMVIQTLTRICADAQSVVDIYVN 565

  Fly   508 YDCDLYCTDMFESLTNLLSKYT-------LSATNA-VYSTHIISMDTLLSVIDSIERNCAA--SK 562
            |||||...::||.|.|.|||..       |..:|. ..|.....::.|:|::     .|..  ||
  Rat   566 YDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSIL-----KCMVEWSK 625

  Fly   563 N---SSNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINASSHRLRLQ 624
            :   :.|::.:|.:..|:.......:|                 .|.:....|..:..|      
  Rat   626 DQYVNPNSQTTLGQEKPSEQEISEIKH-----------------PETINRYGSLNSLES------ 667

  Fly   625 SGGEGVGITS---------EQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQV 680
            :...|:|..|         ||...:||:|.::.||.:.||::|::|||||||.|:|..  .|..:
  Rat   668 TSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGT--TPEDI 730

  Fly   681 ALFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIF 745
            |.||.:...||....||::......:.:::..:||..||:|.....||||:||.|||||||..|.
  Rat   731 AQFLHQEERLDSTQAGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRLFLEGFRLPGEAQKID 795

  Fly   746 LVLEHFSDHWHK--QNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLN 808
            .::|.|:..:.:  |.|..||:.|.|:.|||:||||..|.|:...|.   .||.|.:.|..||:|
  Rat   796 RLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKN---KMTKEQYIKMNRGIN 857

  Fly   809 GGEDFDQEMLAQVFNAI--------KNEEIVMPAEQTGL-VRENYQWKVL--------------- 849
            ..:|..:|.|:.::|.|        :.:|:.:|.:.|.. |....|.::|               
  Rat   858 DSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSTKQNVASEKQRRLLYNLEMEQMAKTAKAL 922

  Fly   850 ------LRRGDTHDGHFHYVHDASYDVEIFNIVWGASLSALSFMFDKSTETGY-QRTLAGFSKSA 907
                  ::...|...|..:|.      .:|.:.|...|:|.|.......:|.. ...|.|...:.
  Rat   923 MEAVSHVQAPFTSATHLEHVR------PMFKLAWTPFLAAFSVGLQDCDDTDVASLCLEGIRCAI 981

  Fly   908 AISAHYNLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVH 972
            .|:..:::..:.||.|..|.:||.|..|....|....|.:|               ::|:..:.|
  Rat   982 RIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQKNIDT---------------IKTLITVAH 1031

  Fly   973 DYGDCLRESWKHILDLYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEKPREKQESGLFSSLYSF 1037
            ..|:.|..||..||....||...:|:...:                  |||             :
  Rat  1032 TDGNYLGNSWHEILKCISQLELAQLIGTGV------------------KPR-------------Y 1065

  Fly  1038 ISS-----EGQREPTYEE--QDFIKLGRKCIKECQLDQMLQESKFVQLESLQELLKCVLALLKAP 1095
            ||.     ||....|.::  .:|:.||   :....:|       :.|:.|:||            
  Rat  1066 ISGTVRGREGSLTGTKDQAPDEFVGLG---LVGGNVD-------WKQIASIQE------------ 1108

  Fly  1096 QGHKSIGLPYAEDQTVFWMEFLVKIVVHNRDRMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIV 1160
                |||            |...:.||...||:.                   .|...|....||
  Rat  1109 ----SIG------------ETSSQSVVVAVDRIF-------------------TGSTRLDGNAIV 1138

  Fly  1161 AVLKLAIYLMRNEELCPIVLQSLKMLLMLKPALLLRISKQISIGIYELLKTSAQNIHSEQDWQII 1225
            ..::.         ||.:   |:..||......:..:.|.:.|..|.:.:...|   ..:.|::|
  Rat  1139 DFVRW---------LCAV---SMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQ---WSRIWEVI 1188

  Fly  1226 ---FNLLECVGAGAVPPNYDDAQLPLPPNGSAKSDGAISGEEDATAVPERGYTSDSEITKASAAP 1287
               ||.:.|      .||.|.|...:.           |..:.:....|:|..::....|....|
  Rat  1189 GDHFNKVGC------NPNEDVAIFAVD-----------SLRQLSMKFLEKGELANFRFQKDFLRP 1236

  Fly  1288 AVSSPSAENWILVNNKDSELTTASRPQSPPSLSAPPVNTLVYNC--QLLDHAPFALFKCWDS--- 1347
            .       ..|:..|:                 :|.:..:|..|  |:::.....:...|.:   
  Rat  1237 F-------EHIMKRNR-----------------SPTIRDMVVRCIAQMVNSQAANIRSGWKNIFS 1277

  Fly  1348 ---------------LAFIVRSVAHI-----------TPYNFEACVRCIRIFVEACR----DGGI 1382
                           |||  ::..||           |..:|:..|:|:..|  ||.    |..:
  Rat  1278 VFHLAASDQDESIVELAF--QTSGHIVTLVFEKHFPATIDSFQDAVKCLSEF--ACNAAFPDTSM 1338

  Fly  1383 RQRRKLESAAKQKSSKKRSERKPGMASSASSSNLTLLTGDPSDNQINGNAAEQEDLAQRYEQLSI 1447
            ...|.:...||..|.:                                                 
  Rat  1339 EAIRLIRHCAKYVSDR------------------------------------------------- 1354

  Fly  1448 QLLDLMYTLYTRTAQIFRWWAEEGCTVPQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQ 1512
                         .|.|:.:..:...|.....:|..||.|:|..::.:....:.:|||..::   
  Rat  1355 -------------PQAFKEYTSDDMNVAPEDRVWVRGWFPILFELSCVINRCKLDVRTRGLT--- 1403

  Fly  1513 QRALLVHDLQTLSGT---EWCSCFHQVLFPLLNEL-LPESNAAGQLDAALLEESRIRTAT----- 1568
               ::...::|...|   .|.....:::|.:.:.: |||...         |::...|.|     
  Rat  1404 ---VMFEIMKTYGHTYEKHWWQDLFRIVFRIFDNMKLPEQQT---------EKAEWMTTTCNHAL 1456

  Fly  1569 -IMSKVFLQHLTTL--IELGNAFNELWLDILDYIERFMKVGSDTLSEQMQEILKNMLLVMHSVRV 1630
             .:..||.|:|..|  :.|.:.|.:|:..:....|:..:.|::.|               .:|.:
  Rat  1457 YAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSGTNCL---------------ENVVI 1506

  Fly  1631 FHNQDGSLQQALWE------------------LTWR-RIGEFLPNLKEELFHDEGKRAQTLTNPA 1676
            .:.:..:|:  :|:                  |||| ..||..|.....:   ..|:...::..:
  Rat  1507 LNGEKFTLE--IWDKTCNCTLDIFKTTIPHALLTWRPTSGEAAPPSPSAM---SEKQLDAISQKS 1566

  Fly  1677 PQAAVAAAP-----QQQLPAVTILPRQTQVS 1702
            .....:|.|     :||.|.|::.|...:||
  Rat  1567 VDIHDSAQPRSSDNRQQAPLVSVSPASEEVS 1597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
garzNP_610761.2 COG5307 346..>1062 CDD:227623 194/810 (24%)
Sec7_N 370..512 CDD:289549 34/153 (22%)
Sec7 643..830 CDD:279680 72/196 (37%)
Arfgef1NP_001263985.1 DCB, DCB:DCB domain and DCB:HUS domain interaction. /evidence=ECO:0000250 2..224 33/156 (21%)
PLN03076 15..1763 CDD:215560 375/1851 (20%)
DCB 29..210 CDD:292830 31/142 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 217..248 6/40 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..302 8/47 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 347..410 10/62 (16%)
Sec7_N 416..570 CDD:289549 34/154 (22%)
HUS, DCB:HUS domain interaction. /evidence=ECO:0000250 554..574 8/19 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..684 10/75 (13%)
Sec7 695..879 CDD:279680 72/188 (38%)
Nuclear localization signal (NLS). /evidence=ECO:0000250 708..712 1/3 (33%)
DUF1981 1217..1297 CDD:286414 14/105 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1571..1600 9/27 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342729
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5307
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D815698at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.750

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