DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and Arfgef2

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_851597.2	Gene:	Arfgef2 / 296380	RGDID:	631430	Length:	1791	Species:	Rattus norvegicus

Alignment Length:	1829	Identity:	355/1829 - (19%)
Similarity:	640/1829 - (34%)	Gaps:	528/1829 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 IEPQVFLAPFLEVIRTADATGPLTSLALASVNKLLSYGLIDPTSPNLA----DIVERIADAVTHA 121
            ||...:..||  .:.....:..:.|.:|..:.||::||.|...:|:..    .:::||.:.|.:.
  Rat    63 IEADKYFLPF--ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETVCNC 125

  Fly   122 RFMGTDQSSDGVTFMRVIEVLHTLIRSP-----EGAAVSNVSMCEVMLSCFKISFEPRLSELLRR 181
             |.| .|:.:||. :::|:.|.|.:.||     ||..:..|.      :|:.|....: :.:.:.
  Rat   126 -FQG-PQTDEGVQ-LQIIKALLTAVTSPHIEIHEGTILQTVR------TCYNIYLASK-NLINQT 180

  Fly   182 SAEKSLKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRKSSAV 246
            :|:.:|..|:.:.|.|:       .:.:||:...:........|..:.:.|....:.:..|.|..
  Rat   181 TAKATLTQMLNVIFTRM-------ENQVLQEARELEKPIQSKPQSPVIQATAGSPKFSRLKQSQA 238

  Fly   247 EEPPQTPQSANLTVPGHLKAPI----------------LATTPASPAGN--------ILDMQGKI 287
            :..|.||:...|....|.::.:                ..:..|.|:|.        :.|:...:
  Rat   239 QSKPTTPEKTELPNGDHARSSLGKVNSENGEAHRERGSSISGRAEPSGGSDNGAQEVVKDILEDV 303

  Fly   288 TQTPTTTASTGE--------------DETTVPETPVIQVESTESEPLLDGETGEATSTLAEANSS 338
            ..:....|:..:              .|.|||  |.:. |::::..:.|.....:::...|.::.
  Rat   304 VTSAVKEAAEKQGLPEPDQAPGVPECQECTVP--PAVD-ENSQTNGIADDRQSLSSADNLEPDAQ 365

  Fly   339 EYINSVGVRFTQQSTDHDVTSLSPYGLPFIQELFRFLII--LC----NPLDKQNSDSMMH----- 392
            .:  .|..||:.                 |.:...||:.  ||    .||.:...|...|
  Rat   366 GH--PVAARFSH-----------------ILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSK 411

  Fly   393 -TGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLRGH 456
             ..|.||....:.|......:|..:..:|..||..|.....|....:|...|.:...|..:.:.|
  Rat   412 VVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMH 476

  Fly   457 LKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESL 521
            ||.|:|.:.:::...|. :...:.:|.|.:.:..|.::......|.::|:||||||...::||.|
  Rat   477 LKMQIEVFFKEIFLNIL-ETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERL 540

  Fly   522 TNLLSKYTLSATNAVYSTHIISM-------------DTLLSVIDSI---ERNCAASKN--SSNNR 568
            .|.|||.....     |.|.:.|             :.|:|::..:   .::...:.|  ::..:
  Rat   541 VNDLSKIAQGR-----SGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQATLGQ 600

  Fly   569 ESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINASSHRLRLQSGGEGVGIT 633
            |.||:.....|                 .|..:|....|.::.|.:          |.|....|.
  Rat   601 ERLPDQEMGDG-----------------KGLDMARRCSVTSVESTV----------SSGTQTAIP 638

  Fly   634 S--EQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIG 696
            .  ||...:||:|.::..|.|.||::|::|||:|||.|:|.|.::  .:|.||.:...||...:|
  Rat   639 DDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVE--DIAQFLHQEERLDSTQVG 701

  Fly   697 EYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHK--QN 759
            |::......:.:::..:||..||.......|||.:||.|||||||..|..::|.|:..:.:  |.
  Rat   702 EFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQG 766

  Fly   760 QDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNA 824
            |..||:.|.|:.|||:||||..|.|:...|.   .||.|.:.|..||:|..:|..:|.|:.::..
  Rat   767 QTLFASADTAYVLAYSIIMLTTDLHSPQVKN---KMTKEQYIKMNRGINDSKDLPEEYLSSIYEE 828

  Fly   825 IKNEEIVM-----------------PAEQTGLVRENYQWKVLLRRGD-------------THDGH 859
            |:.::|.|                 .:|:...:..|.:.:.:.:...             |...|
  Rat   829 IEGKKIAMKETKEHTMATKSTKQNVASEKQRRLLYNVEMEQMAKTAKALMEAVSHAKAPFTSATH 893

  Fly   860 FHYVHDASYDVEIFNIVWGASLSALSFMFDKSTETGY-QRTLAGFSKSAAISAHYNLHSDFDALV 923
            ..:|.      .:|.:||...|:|.|.......:|.. ...|.|...:..|:..:.:..:.||.|
  Rat   894 LDHVR------PMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAYV 952

  Fly   924 LTLCKFTTLLSSVEQHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDL 988
            ..|.:|:.|.:|....|....|.:|               ::|:..:.|..|:.|..||..||..
  Rat   953 QALARFSLLTASSSITEMKQKNIDT---------------IKTLITVAHTDGNYLGNSWHEILKC 1002

  Fly   989 YLQLFRLKLLPKSLIEVEDFCEANGKAMLILEKPREKQESGLFSSLYSFISSEGQREPTYEEQDF 1053
            ..||           |:........|...:....||::.|....||..              ::|
  Rat  1003 ISQL-----------ELAQLIGTGVKTRYLSGSGREREGSLKGHSLAG--------------EEF 1042

  Fly  1054 IKLGRKCIKECQLDQMLQESKFVQLESLQELLKCVLALLKAPQGHKSIGLPYAEDQTVFWMEFLV 1118
            :.||...:....:|:.       |:.|.||                |:|            |...
  Rat  1043 MGLGLGNLVSGGVDKR-------QMASFQE----------------SVG------------ETSS 1072

  Fly  1119 KIVVHNRDRMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLAIYLMRNEELCPIVLQSL 1183
            :.||...||:.                   .|...|....||..::.         ||.:   |:
  Rat  1073 QSVVVAVDRIF-------------------TGSTRLDGNAIVDFVRW---------LCAV---SM 1106

  Fly  1184 KMLLMLKPALLLRISKQISIGIYELLKTSAQNIHSEQDWQII---FNLLECVGAGAVPPNYDDAQ 1245
            ..|.......:..:.|.:.|..|.:.:...|   ..:.|.:|   ||.:.|      .||.|.|.
  Rat  1107 DELASPHHPRMFSLQKIVEISYYNMNRIRLQ---WSRIWHVIGDHFNKVGC------NPNEDVAI 1162

  Fly  1246 LPLPPNGSAKSDGAISGEEDATAVPERGYTSDSEITKASAAPAVSSPSAENWILVNNKDSELTTA 1310
            ..:.           |..:.:....|:|..::....|....|.       ..|:..|:
  Rat  1163 FAVD-----------SLRQLSMKFLEKGELANFRFQKDFLRPF-------EHIMKKNR------- 1202

  Fly  1311 SRPQSPPSLSAPPVNTLVYNC--QLLDHAPFALFKCWDS------------------LAFIVRSV 1355
                      :|.:..:|..|  |::......:...|.:                  |||  ::.
  Rat  1203 ----------SPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAF--QTT 1255

  Fly  1356 AHITPY-----------NFEACVRCIRIFVEACR----DGGIRQRRKLESAAKQKSSKKRSERKP 1405
            .||...           :|:..|:|:..|  ||.    |..:...|.:....|..|      .:|
  Rat  1256 GHIVSTIFQHHFPAAIDSFQDAVKCLSEF--ACNAAFPDTSMEAIRLIRFCGKYVS------ERP 1312

  Fly  1406 GMASSASSSNLTLLTGDPSDNQINGNAAEQEDLAQRYEQLSIQLLDLMYTLYTRTAQIFRWWAEE 1470
            .:....:|.::.:..||
  Rat  1313 RVLQEYTSDDMNVAPGD------------------------------------------------ 1329

  Fly  1471 GCTVPQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQRALLVHDLQTLSGTEWCSCFHQ 1535
                    .:|..||.|:|..::.:....:.:|||..::.:.:   ::..........|.....:
  Rat  1330 --------RVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFE---IMKSYGHTFAKHWWQDLFR 1383

  Fly  1536 VLFPLLNEL-LPESNAAGQLDAALLEESRIRTAT------IMSKVFLQHLTTLIELGNAFNELWL 1593
            ::|.:.:.: |||..:         |:|...|.|      .:..||.|....|.|:      |..
  Rat  1384 IVFRIFDNMKLPEQQS---------EKSEWMTTTCNHALYAICDVFTQFYEALHEV------LLS 1433

  Fly  1594 DILDYIERFMKVGSDTLSEQMQEILKNMLLVMHSVRVFHNQDGSLQQALWE-------------- 1644
            |:...::..:|..::.|:......|:|:::         :.......|:|:
  Rat  1434 DVFAQLQWCVKQDNEQLARSGTNCLENLVI---------SNGEKFSPAVWDETCNCMLDIFRTTI 1489

  Fly  1645 ----LTWRRIGEFLPNLKEE-----------------LFHDEGKRAQT-LTNPAPQAAVAA--AP 1685
                ||||..|     ::||                 :..:..:|.|: |:||...:...|  |.
  Rat  1490 PHVLLTWRPAG-----MEEEVSDRHLDVDLDRQSLSSIDRNASERGQSQLSNPTDDSWKGAPYAN 1549

  Fly  1686 QQQLPAVTI 1694
            |:.|.::.|
  Rat  1550 QKLLASLLI 1558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	184/780 (24%)
		Sec7_N	370..512	CDD:289549	36/153 (24%)
		Sec7	643..830	CDD:279680	68/188 (36%)
Arfgef2	NP_851597.2	DCB, DCB:DCB domain and DCB:HUS domain interaction. /evidence=ECO:0000250	2..224		38/179 (21%)
		PLN03076	11..1718	CDD:215560	355/1829 (19%)
		DCB	28..198	CDD:292830	35/153 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..292		12/83 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..350		7/41 (17%)
		Sec7_N	377..531	CDD:289549	36/154 (23%)
		HUS, DCB:HUS domain interaction. /evidence=ECO:0000250	515..535		8/19 (42%)
		Sec7	650..834	CDD:279680	68/188 (36%)
		DUF1981	1174..1255	CDD:286414	14/106 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342754
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750