DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and Iqsec3

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_001028526.1	Gene:	Iqsec3 / 243621	MGIID:	2677208	Length:	1195	Species:	Mus musculus

Alignment Length:	1191	Identity:	256/1191 - (21%)
Similarity:	397/1191 - (33%)	Gaps:	416/1191 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 RLSELLRRSAEKSLKDMVLLFFMRLPQFAEERS----DTMLQKRFTIG----------------D 218
            |:.||.||..|.|               ||.||    ..:||.:...|                .
Mouse    35 RIDELERRLDELS---------------AENRSLWEHQQLLQAQPPPGLVPPPPSAPLPAPAVTA 84

  Fly   219 AASGATQEKLK-----------------RKTVAQAQTAPRKSSAVEEPPQTPQSANL--TVPG-- 262
            .|:.|.||.|:                 .:.:||.|.||  ||.|    |||||.:.  ..||
Mouse    85 PAAAAAQEPLQDHGQLIPASPEPPLQHHGQLLAQPQPAP--SSRV----QTPQSPHQHPVAPGAI 143

  Fly   263 --------------------HLKAPIL----------------------ATTPASPA-------- 277
                                |.....|                      |.|...||
Mouse   144 ADKEKERPSSCCAAAGALLQHASPAALGKGVLSRRPENETVLHQFCCPAADTEQKPACSDLASQS 208

  Fly   278 -GNILDMQGKITQTPTTTASTGEDETTVP--ETPVIQVE--------STESEPLLDGETGEATST 331
             |:.....|.:..:.....:.|......|  :.|.:|.|        |..:.||.....|.....
Mouse   209 DGSCAQAGGGMEDSVVAAVAAGRPSAHAPKAQAPELQQEEERPGAVGSPRAGPLRAASPGRQQPA 273

  Fly   332 LAEA------NSSEYINSVGVRFTQ-QSTDHDVTS--LSPYGLPFIQELFRFLIILCNPLDKQNS 387
            ||.|      .:|||..|:.::..| :..:|....  :|......||..||...:..|....:||
Mouse   274 LATALCSHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNS 338

  Fly   388 --DSMMHTGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSI---FAADLQLCF 447
              :|.:...:||..|....|...:.: :.|||     .| .|:.|......|:   ||..|
Mouse   339 LLESRLPRRISLRKVRAPTAESLVAE-KALLE-----GC-GLLGLPLGRSPSLPPTFAGSL---- 392

  Fly   448 LLFESLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWR----IPGFVTE----- 503
               ..|......|:::..:.:.:.:::.:.||...::|.....|.|...    .||..||
Mouse   393 ---TELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETEAAARE 454

  Fly   504 -------------LYINYDCDLYCTDMFESLTNLLSKYTLSATNAVYSTHIISMDTLLSVIDSIE 555
                         |...:...|...  |..:|..::...:|          :|..|.|||
Mouse   455 PESGPGSGDEAGGLPQGHSGTLMMA--FRDVTVQIANQNIS----------VSSSTALSV----- 502

  Fly   556 RNCAASKNSSNNRESLPEAA---------------PAT---------GGSRHSRHNSGLE----G 592
            .||..::.:....|  |.||               ||:         ..:..||..|..|    .
Mouse   503 ANCLGAQTAQATAE--PAAAQAEQEDTADQEVSEVPASEQMDPPSEDSEAAESRAQSAQEPAVAQ 565

  Fly   593 IVIDSGNSVAAEEKVE---------------NIASFINASSHRLRLQSGGEGVGITSEQ------ 636
            .|::...:..|||:.|               |.....::|:.....:|..|.....|::
Mouse   566 AVVEEAVATEAEEEEEGAKQAGKGAEAEGGDNSEQLSSSSASTKSAKSSSEASAAASKEALQAVI 630

  Fly   637 ------------------LAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALF 683
                              |:....:|||...|...||..|:||||:|...|.:..  .|:.||.|
Mouse   631 LSLPRYHCENPASCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPD--TPIGVAHF 693

  Fly   684 LRENPGLDKKMIGEYI-SKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLV 747
            |.:..||.::||||:: :.||..:..:|...||..||:.:.:|:|||.:....|:.|||..:..:
Mouse   694 LLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERL 758

  Fly   748 LEHFSDHWHKQNQD---PFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNG 809
            :|.||..:...|.:   .|.|.|..|.||:|||:||.|.::.|.|. :..|.||||.:||||::.
Mouse   759 IEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKP-DRKMMLEDFIRNLRGVDD 822

  Fly   810 GEDFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFN 874
            |.|..:|::..::..|:.:|:                       .:::.|..||
Mouse   823 GADIPRELVVGIYERIQQKEL-----------------------KSNEDHVTYV----------- 853

  Fly   875 IVWGASLSALSFMFDKSTETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQH 939
                               |..::::.|. |:.....|..         |..|.....::.|
Mouse   854 -------------------TKVEKSIVGM-KTVLSMPHRR---------LVCCSRLFEVTDV--- 886

  Fly   940 EPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIE 1004
                  |:.|         |..|..|.|||    :.|.              |..|||.||....
Mouse   887 ------NKLQ---------KQAAHQREVFL----FNDL--------------LVILKLCPKKKSS 918

  Fly  1005 -VEDFCEANGKAMLILEKPREKQESGLFS---SLYSFISSEGQREPTYEEQDFIKLGRKCIKECQ 1065
             ...||:|.|    :|.......|:..:|   :|.:.:|...:::..:    |..||.
Mouse   919 FTYTFCKAVG----LLGMRFHLFENEYYSHGITLATPLSGSEKKQVLH----FCALGS------- 968

  Fly  1066 LDQMLQESKFVQLESLQELLKCVLAL--------LKAPQGHKSI---------------GLPYAE 1107
             |:|   .|||  |.|:|.:..|..|        |:..||.|::               |.|.|:
Mouse   969 -DEM---QKFV--EDLKESIAEVTELEQIRIEWELEKQQGTKTLSVRSAGAQGDPQSKQGSPTAK 1027

  Fly  1108 DQTVFW---MEFLVKIVVHNR 1125
            .:.:..   .|...::.:|||
Mouse  1028 REAMAGEKAAESSGEVSIHNR 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	177/820 (22%)
		Sec7_N	370..512	CDD:289549	32/168 (19%)
		Sec7	643..830	CDD:279680	70/190 (37%)
Iqsec3	NP_001028526.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..139		19/82 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..272		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	440..474		5/33 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..615		18/100 (18%)
		Sec7	655..843	CDD:279680	70/190 (37%)
		PH_IQSEC	870..1000	CDD:270128	42/195 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1100		8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1138..1175
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740