DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and PSD3

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_016868747.1	Gene:	PSD3 / 23362	HGNCID:	19093	Length:	1067	Species:	Homo sapiens

Alignment Length:	990	Identity:	199/990 - (20%)
Similarity:	341/990 - (34%)	Gaps:	257/990 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 SDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRKSSAVEEP--------PQTPQSANLTVPG 262
            |.|:...:....||.|..:.:::::    :..||.||:..|.:.        |:.|.||.:|...
Human   167 SGTLQATKVLDQDAVSSFSVQQVEK----ELDTASRKTQRVNKTLPAGQKNLPEIPLSAEVTTEE 227

  Fly   263 HLKAPILATTPASPAGNILDMQGKITQTPTTTASTGEDETTVPETPVIQVESTESEPLLDGETG- 326
            .....|.....|...|   |.|.:|:|. ......|......|..|:..:.|:.......|..|
Human   228 SFYLSIQKDLTALLTG---DTQAEISQI-MNNGRKGAVCVQEPSCPLASLGSSAVTCHSAGSVGF 288

  Fly   327 ----------------EATSTLAEANSSEYINSVGV---------RFTQQSTDHDVTSLSPYGLP 366
                            :.:|::......:::...||         |.||...|.: |||.....|
Human   289 LKEQRSALGREHPGGCDRSSSMGRPGRVKHVEFQGVEILWTGGDKRETQHPIDFE-TSLQRTASP 352

  Fly   367 FIQE---LFRFLII---LCN---------------PLDKQNSDSMMHTGLSLLTVAFEVAADNIG 410
            ..:|   :.|.||.   |||               |.::..:.|...:.:.|         |..|
Human   353 DSKESSKVPRHLISSAGLCNSSSLTENVWDESWKAPSERPGTSSGTFSPVRL---------DESG 408

  Fly   411 KYEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEIIASD 475
            :.|..|:..|..|.:........||:|                      :.|.:::...|.|..
Human   409 EDEVFLQENKQHLEKTPKPERDRERIS----------------------EQEEHVKGEDEDILG- 450

  Fly   476 NPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTLSATNAVYSTH 540
                                  ||:..:     ..|:| :..||::        |..|:..||..
Human   451 ----------------------PGYTED-----STDVY-SSQFETI--------LDNTSLYYSAE 479

  Fly   541 IISMDTLLSVIDSI----------------ERNCAASKNSSNNRESLPEAAPATGGSRHSRHNSG 589
              |::||.|..||.                |......:.|....:.:...: |.||.... ::||
Human   480 --SLETLYSEPDSYFSFEMPLTPMIQQRIKEGGQFLERTSGGGHQDILSVS-ADGGIVMG-YSSG 540

  Fly   590 LEGIVIDSGNSVAAEEKVENIASFINASSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERF 654
            :...:.|:.:|:..:...|......||.....||::..|   :.|.::.: |:....||.||...
Human   541 VTNGLNDASDSIYTKGTPEIAFWGSNAGVKTTRLEAHSE---MGSTEILE-KETPENLSNGTSSN 601

  Fly   655 NQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDF 719
            .:..::..:.|            .|:..|.|.:       :.:::.|.......:...::..|||
Human   602 VEAAKRLAKRL------------YQLDRFKRSD-------VAKHLGKNNEFSKLVAEEYLKFFDF 647

  Fly   720 TGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQH 784
            ||:.:||:||.:.:.|.|.||......||.|||:.:...|.|..|:.|....|..||::||.|.|
Human   648 TGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLH 712

  Fly   785 NSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEI----------VMPAEQTGL 839
            ..|   :...||.::|..||:|:|.|.||.:::|..::|:||||::          ..|:|.|..
Human   713 GHN---IGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEE 774

  Fly   840 VRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFNIVWGASLSALSFMFDKSTETGYQRTLAGFS 904
            .......|.:.|.|.|.:......||.:                                 |...
Human   775 KANGTHPKTISRIGSTTNPFLDIPHDPN---------------------------------AAVY 806

  Fly   905 KSAAISAHYNLHSDFDA-----------LVLTLCKFTTLLSSVEQHEPAPANNE----TQQAVNF 954
            ||..::.  .:|:|.|.           ....:.|.|.|....::::|..|.:|    ...:|:.
Human   807 KSGFLAR--KIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHH 869

  Fly   955 GLNGKAQAAMR--TVF---------LLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIEVEDF 1008
            .|..||....:  .||         ||.........:.|.:.::....:|.....|.::...:.|
Human   870 ALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKF 934

  Fly  1009 CEANGKAMLILEKPREKQESGLFS--SLYSFISSEGQREPTYEEQDFIKLGRKCIKECQLDQMLQ 1071
                .:.:|.....:..||..|.|  |....|::|.....:|.....:|  .|.:.|.:|.....
Human   935 ----SRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVK--AKDVDEYKLKDHYL 993

  Fly  1072 ESKFVQLESLQELLK 1086
            |.:..:.|....:||
Human   994 EFEKTRYEMYVSILK 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	163/799 (20%)
		Sec7_N	370..512	CDD:289549	24/162 (15%)
		Sec7	643..830	CDD:279680	55/186 (30%)
PSD3	XP_016868747.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148847
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740