DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and Iqsec1

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_006506046.1	Gene:	Iqsec1 / 232227	MGIID:	1196356	Length:	1203	Species:	Mus musculus

Alignment Length:	794	Identity:	192/794 - (24%)
Similarity:	302/794 - (38%)	Gaps:	243/794 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 PRL---SELLRRSAE-------KSLKDMVLLFFMRLPQFAEERSDTMLQKRF-----------TI 216
            |||   :.:||:.||       :||.:.     ..|....:::...||::::           ||
Mouse   171 PRLQHSTSVLRKQAEEEAIKRSRSLSES-----YELSSDLQDKQVEMLERKYGGRLVTRHAARTI 230

  Fly   217 GDA-------------ASGATQEKLKRKTVAQAQTAPRKSSAVEEPPQTPQS------ANLT--- 259
            ..|             .|..::.::.|:.|....   |...:.|.|.:...|      .::|
Mouse   231 QTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNM---RMQFSFEGPEKVHSSYFEGKQVSVTNDG 292

  Fly   260 ------VP---GHLKAPIL-ATTPASP-AGNILDMQGKITQTPTTTASTGED--------ETTVP 305
                  ||   |.|..|.| :..|:|. |..|.:::...::...:.|.:.:|        ...||
Mouse   293 SQLGALVPSECGDLSDPALKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEVP 357

  Fly   306 ETPVIQVESTESEPLLDG----ETGEATSTLAEANSSEYINSVGVRFTQQSTDHDVTSLSPYGLP 366
            .:...:...||.:|.|.|    :..|.|::.::.  :.||              |...||| .||
Mouse   358 ASDTARARDTEPKPGLHGMDHRKLDEMTASYSDV--TLYI--------------DEEELSP-PLP 405

  Fly   367 FIQELFRFLIILCNPLDKQNSDSMMHTGLSLLTVAFEVAADNIGKYEGLLELVKDD------LCR 425
            ..|...|       | ....||..:.:|        ..|.|    |..|..  |:|      .||
Mouse   406 LSQAGDR-------P-SSTESDLRLRSG--------GAAQD----YWALAH--KEDKADTDTSCR 448

  Fly   426 NLISLLSSE-RLSIFAADLQLCFLLFE------------SLRGHLKFQLEAYLRKLSEIIASDN- 476
            :..||...| ||.:    ..|..|..|            |.|..||.| .||.|.|.....|..
Mouse   449 STPSLERPEPRLRV----EHLPLLTIEPPSDSSVELSDRSDRSSLKRQ-SAYERSLGGQQGSPKH 508

  Fly   477 ------PK-TPYEMRELALDNLLQLWRIP-GFVTELYINYDCDLYCTDMFESLTNLLSK----YT 529
                  || .|.|..||..       |.| ...:.|.||            ...|..||    |:
Mouse   509 GPHGGPPKGLPREEPELRP-------RPPRPLESHLAIN------------GSANRQSKSESDYS 554

  Fly   530 LSATNAVYSTHIISMDTLLSVIDSIERNCAASKNSSNNRESLPEAAPATGGSRHSRHNSGLEGIV 594
            ....:::.||. .|.||:         ||:   :.|::|:||.|..
Mouse   555 DGDNDSINSTS-NSNDTI---------NCS---SESSSRDSLREQT------------------- 587

  Fly   595 IDSGNSVAAEEKVENIASFINASSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPE 659
                               ::..::....::..:....:::.:     :||....|...||::||
Mouse   588 -------------------LSKQTYHKETRNSWDSPAFSNDVI-----RKRHYRIGLNLFNKKPE 628

  Fly   660 KGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIGEYI-SKKKNVDSKILINFVDSFDFTGLR 723
            ||||||.|.|.:..  .|:.||.||.:..||.::||||:: :::|..:..:|...||..||:.:.
Mouse   629 KGIQYLIERGFVPD--TPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAME 691

  Fly   724 VDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQD---PFANVDAAFRLAYAIIMLNMDQHN 785
            :|:|||.:....|:.|||..:..::|.||..:...|..   .|.|.|..|.||:|||:||.|.::
Mouse   692 LDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYS 756

  Fly   786 SNAKRLNVP---MTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENYQWK 847
            .|.|    |   |.||||.|||||::.|||..:|.|..::..|:..|:....:....|::  ..|
Mouse   757 PNVK----PERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQK--VEK 815

  Fly   848 VLLRR---GDTHDG 858
            :::.:   |..|.|
Mouse   816 LIVGKKPIGSLHHG 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	146/555 (26%)
		Sec7_N	370..512	CDD:289549	42/169 (25%)
		Sec7	643..830	CDD:279680	75/193 (39%)
Iqsec1	XP_006506046.1	Sec7	612..800	CDD:366596	75/193 (39%)
Iqsec1	XP_006506046.1	IQ_SEC7_PH	832..962	CDD:374551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838946
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840