Protein Alignment garz and IQSEC2

DIOPT Version :10

• Sequence 1: NP_610761.2
• Gene: garz / 36337
• FlyBaseID: FBgn0264560
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_006724642.1
• Gene: IQSEC2 / 23096
• HGNCID: 29059
• Length: 1520
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 140/614 - (22%)
• Similarity: 233/614 - (37%)
• Gaps: 206/614 - (33%)

  Fly   557 NCAASKNSSNNRESLPEAAPATG-----GSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINA 616
            ||:   :.|::|:||.| .||||     ..|.:||          |.:|.|....|      :..
Human   742 NCS---SGSSSRDSLRE-PPATGLCKQTYQRETRH----------SWDSPAFNNDV------VQR 786

  Fly   617 SSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVA 681
            ..:|:                            |...||::||||||||.|.|.|:.  .|:.||
Human   787 RHYRI----------------------------GLNLFNKKPEKGIQYLIERGFLSD--TPVGVA 821

  Fly   682 LFLRENPGLDKKMIGEYI-SKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIF 745
            .|:.|..||.::||||:: :::|..:..:|...||..||:.:.:|.|||.:....|:.|||..:.
Human   822 HFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVE 886

  Fly   746 LVLEHFSDHWHKQNQ---DPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGL 807
            .::|.||..:...|.   ..|.|.|..|.||:|||:||.|.::.:.| ....|.|:||.|||||:
Human   887 RLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVK-AERKMKLDDFIKNLRGV 950

  Fly   808 NGGEDFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEI 872
            :.|||..:::|..::..|:..|:                       .|:|.|...|.
Human   951 DNGEDIPRDLLVGIYQRIQGREL-----------------------RTNDDHVSQVQ-------- 984

  Fly   873 FNIVWGASLSALSFMFDKSTETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVE 937
                                  ..:|.:.|  |...:|..:.                .|:...:
Human   985 ----------------------AVERMIVG--KKPVLSLPHR----------------RLVCCCQ 1009

  Fly   938 QHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCL-----------------RESWKHI 985
            .:| .|..|..|:   .||:      .|.|||    :.|.|                 |:|:. :
Human  1010 LYE-VPDPNRPQR---LGLH------QREVFL----FNDLLVVTKIFQKKKILVTYSFRQSFP-L 1059

  Fly   986 LDLYLQLFR-------LKLLP-----------------------------KSLIEVEDFCEANGK 1014
            :::::|||:       :|||.                             :|:.||::..:...:
Human  1060 VEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVE 1124

  Fly  1015 AMLILEK----PREKQESGLFSSLYSFISSEGQREPTYEEQDFIKLGRKCIKECQLDQMLQESKF 1075
            :.|..:|    |...|..|...|:...: :....|.||...|.:|.|........|....:..:.
Human  1125 SELEKQKGMMRPNASQPGGAKDSVNGTM-ARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRR 1188

  Fly  1076 VQLESLQELLKCVLALLKAPQGHKSIGLP 1104
            ..:.||...::.  :::.:|:.|:.:..|
Human  1189 NSVGSLDSTIEG--SVISSPRPHQRMPPP 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	PLN03076	<395..>986	CDD:215560	113/454 (25%)
		Sec7	643..830	CDD:460178	70/190 (37%)
IQSEC2	XP_006724642.1	ATG16	<23..>64	CDD:462536
		Sec7	785..973	CDD:460178	71/218 (33%)
		IQ_SEC7_PH	995..1124	CDD:465120	25/159 (16%)
		KLF1_2_4_N	<1350..1457	CDD:425360