DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and Psd4

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_001342160.1	Gene:	Psd4 / 215632	MGIID:	2674093	Length:	1005	Species:	Mus musculus

Alignment Length:	858	Identity:	171/858 - (19%)
Similarity:	288/858 - (33%)	Gaps:	284/858 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 SGATQEKLKRKTV-AQAQTAPRKSSAVEE-----PPQTPQSANLTV---PGHLKAPILATTPASP 276
            ||.....|:...| .||:.|.....::|:     .||..||::..|   .|.|:|.:.
Mouse    63 SGVESTHLENCLVQVQARQASASLRSLEDNSSLGSPQQNQSSSTQVVFWAGILQAQMC------- 120

  Fly   277 AGNILDMQGKITQT-----------PTTTASTGEDETTVPETPVIQVESTE--SEPLLDGET--- 325
               :||::.::.:|           |..:.....||...|..|....:|.:  |.|..:.:|
Mouse   121 ---VLDLEEELEKTEGLRAELRCCIPPPSKDLLGDEGLSPSRPEEDEDSGDDSSGPEEENQTWPR 182

  Fly   326 ----GEATSTLAEANSSEYINSVGVR--FTQQSTDHDVTSLS-PYGLPFIQELFRFLIILCNPLD 383
                |.:....||.:|..:.|.:.:.  .:..||:.:..|.. |...|.::...:....|.:||.
Mouse   183 EKIPGSSLEWGAEEDSIFFDNPLFLESPCSDTSTEGECFSWGYPNSHPDMKTWHQSPQTLDSPLQ 247

  Fly   384 K-------QN-----SDSMMHTGLSLLTVAFEVAADN------IGKYEGLLELVKDD----LCRN 426
            |       :|     ||:..|.|.|  |..|.|.:..      :|..||...:..|.    .|.:
Mouse   248 KGTGLWRQENELDLGSDTADHGGCS--TPPFPVPSYKMHPCLALGSTEGDPTVPPDQEGETSCED 310

  Fly   427 LISLLSSERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNL 491
                           ||           ||                  .:||.|:...||..::
Mouse   311 ---------------DL-----------GH------------------GSPKAPFVDHELIQES- 330

  Fly   492 LQLWRIPGFVTELYINYDCDL----------YCTDMFESLTNLL--------------SKYTLSA 532
                          .|::.||          :.:...:||::|.              |:.||.:
Mouse   331 --------------DNFEFDLRPATTHPVQPWGSQTSQSLSDLTQPILEDLQREDPSRSQETLIS 381

  Fly   533 TN-----------AVYSTHIISMDTLLSVIDSIERNCAASKNSSNNRESLPEAAPATGGSRHSRH 586
            .|           .|:.|    :....|....:|.||.    .|..|.|.|:.:|.:......|
Mouse   382 QNRGERDAGCFQEPVFCT----LAPWGSQTSLLEPNCP----ESEGRGSGPQPSPVSSQDSSPR- 437

  Fly   587 NSGLEGIVIDSGN----------------SVAAEEKVENIASF--------------INASSHRL 621
                  :::.|..                |...||:.|.:.|.              .:|:.|.:
Mouse   438 ------VLLHSPKWPQDASHLLQKDRSELSSLKEEETEEVPSLRQEAECEDTSRSEDASANQHHV 496

  Fly   622 RLQSGGEGVGITSEQLAKVKQKKRLLSQGTERF--NQRPEKG-----IQYLQEHGILNAELDPMQ 679
            .|.| .||:..:....|:..::....|...|:.  :.|.:||     ::..|.:|...:|
Mouse   497 HLAS-AEGLPESPMPQAQSPEEGWRPSSSREKLANDIRNDKGAWNLALRLYQLNGFRKSE----- 555

  Fly   680 VALFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLI 744
            ||..||:|....:.:...|:|               .|.|.|..:|:|||.:|:...|.||....
Mouse   556 VAAHLRKNNDFSRAVAEAYLS---------------FFQFEGQSLDRALRGFLQALVLSGETQER 605

  Fly   745 FLVLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNG 809
            ..:|..||..:|..|...|.:||:...|..||::||.|.|..|   :...|:.::|..||.||..
Mouse   606 ERILYQFSKRFHYCNPGAFPSVDSVHTLTCAIMLLNTDLHGQN---IGKSMSCQEFVTNLNGLQD 667

  Fly   810 GEDFDQEMLAQVFNAIKNEEIV--------------MPAEQTGLVRE------------NYQWKV 848
            |.:|.:|:|..::.:|::|::.              .|:...|.:..            .|:..:
Mouse   668 GRNFPKELLKALYWSIRSEKLEWAIDEEDADRPEKDQPSPSAGKISSPFLQMAQDPTMPTYKQGI 732

  Fly   849 LLRRGDTHDGHFHYVHDASYDVEIFNIVWG--------ASLSALSFMFDKSTETGYQ-RTLAGFS 904
            |.|:       .|::.|..      ...||        ..|..:...|.|....... .:|.|..
Mouse   733 LARK-------MHHIADGK------KTPWGKRGWKMFHTLLRGMVLYFLKGEGQWLDGESLVGHM 784

  Fly   905 KSAAISAHYNLHS 917
            ....:..|::|.|
Mouse   785 VDEPVGVHHSLAS 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	138/704 (20%)
		Sec7_N	370..512	CDD:289549	28/163 (17%)
		Sec7	643..830	CDD:279680	54/193 (28%)
Psd4	NP_001342160.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..66		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..189		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..386		24/157 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..525		23/129 (18%)
		Sec7	510..688	CDD:238100	55/200 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..714		2/19 (11%)
		PH_EFA6	722..849	CDD:270107	15/89 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	951..1005
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838948
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830