DRSC/TRiP Functional Genomics Resources

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Protein Alignment garz and Arfgef1

DIOPT Version :9

Sequence 1:NP_610761.2 Gene:garz / 36337 FlyBaseID:FBgn0264560 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_001095900.1 Gene:Arfgef1 / 211673 MGIID:2442988 Length:1846 Species:Mus musculus


Alignment Length:1869 Identity:373/1869 - (19%)
Similarity:665/1869 - (35%) Gaps:543/1869 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 IEPQVFLAPFLEVIRTADATGPLTSLALASVNKLLSYGLI-----DPTSPNLADIVERIADAVTH 120
            ||...:..||  .:........:.|.:|..:.||::||.:     |.|:|. ..:::||.:.:..
Mouse    75 IEADKYFLPF--ELACQSKCPRIVSTSLDCLQKLIAYGHLTGRAPDSTTPG-KKLIDRIIETICG 136

  Fly   121 ARFMGTDQSSDGVTFMRVIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEK 185
            . |.| .|:.:||. :::|:.|.|.:.| :...:...::.:.:.:|:.|....: :.:.:.:|:.
Mouse   137 C-FQG-PQTDEGVQ-LQIIKALLTAVTS-QHIEIHEGTVLQAVRTCYNIYLASK-NLINQTTAKA 196

  Fly   186 SLKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRKSSAVEEPP 250
            :|..|:.:.|.|:...|.:.:..|.::|.        ..|:.|.:..|:..:  |........||
Mouse   197 TLTQMLNVIFARMENQALQEAKQMERERH--------RQQQHLLQSPVSHHE--PESPHLRYLPP 251

  Fly   251 QTPQSANLTVPGHLK-------APILATTPASPAGNILDMQGKITQTPTTTASTGEDETTV---- 304
            ||....|....|.|:       ..:...|......:|...:.:.|:....||:....:..:    
Mouse   252 QTVDHINQEHEGDLEPQTHDVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNDILYDG 316

  Fly   305 --PETPVIQVESTESE--PLLDGETGEA----------TSTLAEANSSEYINSVGV--------- 346
              .|.|:..|:|...|  .::.|:.||.          |.|:.:.:.||.|.:.|:         
Mouse   317 DYEEKPLDIVQSIVEEMVNIIVGDMGEGMAISASTEGNTGTVEDGSDSENIQANGIPGTPISVAY 381

  Fly   347 -------RFTQQSTDHDVTSLSPYGLP-----FIQELFRFLII--LC----NPLDKQNSDSMMH- 392
                   |.:..|.|...:..|....|     .|.:...||:.  ||    .||.....|...| 
Mouse   382 TPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHE 446

  Fly   393 -----TGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFES 452
                 ..|.||....:.|.......|..:..:|..||..|.....|....:|...|.:...|..:
Mouse   447 LRSKILSLQLLLSILQNAGPVFRTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSN 511

  Fly   453 LRGHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDM 517
            .:.|||.|:|.:.:::...|. :...:.::.:.:.:..|.::......|.::|:||||||...::
Mouse   512 FKTHLKMQIEVFFKEIFLYIL-ETSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANI 575

  Fly   518 FESLTNLLSKYT-------LSATNA-VYSTHIISMDTLLSVIDSIERNCAA--SKN---SSNNRE 569
            ||.|.|.|||..       |..:|. ..|.....::.|:|::     .|..  ||:   :.|::.
Mouse   576 FERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSIL-----KCMVEWSKDQYVNPNSQT 635

  Fly   570 SLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINASSHRLRLQSGGEGVGITS 634
            :|.:..|:.......:|                 .|.:....|..:..|      :...|:|..|
Mouse   636 TLGQEKPSEQEISEVKH-----------------PETINRYGSLNSLES------TSSSGIGSYS 677

  Fly   635 ---------EQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGL 690
                     ||...:||:|.::.||.:.||::|::|||||||.|:|..  .|..:|.||.:...|
Mouse   678 TQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGT--TPEDIAQFLHQEERL 740

  Fly   691 DKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHW 755
            |...:||::......:.:::..:||..||:|.....||||:||.|||||||..|..::|.|:..:
Mouse   741 DSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRLFLEGFRLPGEAQKIDRLMEKFAARY 805

  Fly   756 HK--QNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEML 818
            .:  |.|..||:.|.|:.|||:||||..|.|:...|.   .||.|.:.|..||:|..:|..:|.|
Mouse   806 LECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKN---KMTKEQYIKMNRGINDSKDLPEEYL 867

  Fly   819 AQVFNAI--------KNEEIVMPAEQTGL-VRENYQWKVL---------------------LRRG 853
            :.::|.|        :.:|:.:|.:.|.. |....|.::|                     ::..
Mouse   868 SAIYNEIAGKKISMKETKELTIPTKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAP 932

  Fly   854 DTHDGHFHYVHDASYDVEIFNIVWGASLSALSFMFDKSTETGY-QRTLAGFSKSAAISAHYNLHS 917
            .|...|..:|.      .:|.:.|...|:|.|.......:|.. ...|.|...:..|:..:::..
Mouse   933 FTSATHLEHVR------PMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQL 991

  Fly   918 DFDALVLTLCKFTTLLSSVEQHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCLRESW 982
            :.||.|..|.:||.|..|....|....|.:|               ::|:..:.|..|:.|..||
Mouse   992 ERDAYVQALARFTLLTVSSGITEMKQKNIDT---------------IKTLITVAHTDGNYLGNSW 1041

  Fly   983 KHILDLYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEKPREKQESGLFSSLYSFISS-----EG 1042
            ..||....||...:|:...:                  |||             :||.     ||
Mouse  1042 HEILKCISQLELAQLIGTGV------------------KPR-------------YISGTVRGREG 1075

  Fly  1043 QREPTYEE--QDFIKLGRKCIKECQLDQMLQESKFVQLESLQELLKCVLALLKAPQGHKSIGLPY 1105
            ....|.::  .:|:.||   :....:|       :.|:.|:||                |||   
Mouse  1076 SLTGTKDQAPDEFVGLG---LVGGNVD-------WKQIASIQE----------------SIG--- 1111

  Fly  1106 AEDQTVFWMEFLVKIVVHNRDRMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLAIYLM 1170
                     |...:.||...||:.                   .|...|....||..::.     
Mouse  1112 ---------ETSSQSVVVAVDRIF-------------------TGSTRLDGNAIVDFVRW----- 1143

  Fly  1171 RNEELCPIVLQSLKMLLMLKPALLLRISKQISIGIYELLKTSAQNIHSEQDWQII---FNLLECV 1232
                ||.:   |:..||......:..:.|.:.|..|.:.:...|   ..:.|::|   ||.:.| 
Mouse  1144 ----LCAV---SMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQ---WSRIWEVIGDHFNKVGC- 1197

  Fly  1233 GAGAVPPNYDDAQLPLPPNGSAKSDGAISGEEDATAVPERGYTSDSEITKASAAPAVSSPSAENW 1297
                 .||.|.|...:.           |..:.:....|:|..::....|....|.       ..
Mouse  1198 -----NPNEDVAIFAVD-----------SLRQLSMKFLEKGELANFRFQKDFLRPF-------EH 1239

  Fly  1298 ILVNNKDSELTTASRPQSPPSLSAPPVNTLVYNC--QLLDHAPFALFKCWDS------------- 1347
            |:..|:                 :|.:..:|..|  |:::.....:...|.:             
Mouse  1240 IMKRNR-----------------SPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQD 1287

  Fly  1348 -----LAFIVRSVAHI-----------TPYNFEACVRCIRIFVEACR----DGGIRQRRKLESAA 1392
                 |||  ::..||           |..:|:..|:|:..|  ||.    |..:...|.:...|
Mouse  1288 ESIVELAF--QTTGHIVTLVFEKHFPATIDSFQDAVKCLSEF--ACNAAFPDTSMEAIRLIRHCA 1348

  Fly  1393 KQKSSKKRSERKPGMASSASSSNLTLLTGDPSDNQINGNAAEQEDLAQRYEQLSIQLLDLMYTLY 1457
            |..|.:                                                           
Mouse  1349 KYVSDR----------------------------------------------------------- 1354

  Fly  1458 TRTAQIFRWWAEEGCTVPQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQRALLVHDLQ 1522
               .|.|:.:..:..:|.....:|..||.|:|..::.:....:.:|||..::      ::...::
Mouse  1355 ---PQAFKEYTSDDMSVAPEDRVWVRGWFPILFELSCIINRCKLDVRTRGLT------VMFEIMK 1410

  Fly  1523 TLSGT---EWCSCFHQVLFPLLNEL-LPESNAAGQLDAALLEESRIRTAT------IMSKVFLQH 1577
            |...|   .|.....:::|.:.:.: |||...         |::...|.|      .:..||.|:
Mouse  1411 TYGHTYEKHWWQDLFRIVFRIFDNMKLPEQQT---------EKAEWMTTTCNHALYAICDVFTQY 1466

  Fly  1578 LTTL--IELGNAFNELWLDILDYIERFMKVGSDTLSEQMQEILKNMLLVMHSVRVFHNQDGSLQQ 1640
            |..|  :.|.:.|.:|:..:....|:..:.|::.|               .:|.:.:.:..:|: 
Mouse  1467 LEVLSDVLLDDIFAQLYWCVQQDNEQLARSGTNCL---------------ENVVILNGEKFTLE- 1515

  Fly  1641 ALWELTWRRIGEFLPNLKEELFHDEGKRAQTLTNPAPQAAVAAAPQQQLPAVTILPRQTQVSNEL 1705
             :|:.|.        |...::|                                   :|.:.:.|
Mouse  1516 -IWDKTC--------NCTLDIF-----------------------------------KTTIPHAL 1536

  Fly  1706 VVSAPT-----PPAATPLLGSPVESPRRSII-----LQPPMADVLQQPP 1744
            :...||     ||:.:.:...|:::..:..:     :||..:|..||.|
Mouse  1537 LTWRPTSGEAEPPSPSAVSEKPLDAISQKSVDIHDSIQPRSSDNRQQAP 1585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
garzNP_610761.2 COG5307 346..>1062 CDD:227623 194/810 (24%)
Sec7_N 370..512 CDD:289549 34/153 (22%)
Sec7 643..830 CDD:279680 72/196 (37%)
Arfgef1NP_001095900.1 DCB, DCB:DCB domain and DCB:HUS domain interaction. /evidence=ECO:0000250 2..224 33/156 (21%)
PLN03076 15..1763 CDD:215560 373/1869 (20%)
DCB 29..210 CDD:292830 31/142 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 216..249 6/42 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..304 5/39 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 347..410 11/62 (18%)
Sec7_N 416..570 CDD:289549 34/154 (22%)
HUS, DCB:HUS domain interaction. /evidence=ECO:0000250 554..574 8/19 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..684 10/75 (13%)
Sec7 695..879 CDD:279680 72/188 (38%)
Nuclear localization signal (NLS). /evidence=ECO:0000250 708..712 1/3 (33%)
DUF1981 1217..1298 CDD:286414 14/106 (13%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838928
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5307
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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