DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment garz and Cyth2

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_035311.1	Gene:	Cyth2 / 19158	MGIID:	1334255	Length:	400	Species:	Mus musculus

Alignment Length:	219	Identity:	78/219 - (35%)
Similarity:	131/219 - (59%)	Gaps:	8/219 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   620 RLR---LQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVA 681
            |||   .::..|..|:.:.:.:|..|:.|.::.|.::||..|:||||:|.||.:|  :..|.::|
Mouse    35 RLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVEHELL--QNTPEEIA 97

  Fly   682 LFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFL 746
            .||.:..||:|..||:|:.:::.::..:|..|||..:||.|.:.||||.:|.:|||||||..|..
Mouse    98 RFLYKGEGLNKTAIGDYLGEREELNLSVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDR 162

  Fly   747 VLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGE 811
            ::|.|:..:...|...|.:.|..:.|::|:||||...||.|.:  :.| .||.|....||:|.|.
Mouse   163 MMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVR--DKP-GLERFVAMNRGINEGG 224

  Fly   812 DFDQEMLAQVFNAIKNEEIVMPAE 835
            |..:::|..::::|:||...:|.:
Mouse   225 DLPEDLLRNLYDSIRNEPFKIPED 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	78/219 (36%)
		Sec7_N	370..512	CDD:289549
		Sec7	643..830	CDD:279680	70/186 (38%)
Cyth2	NP_035311.1	Sec7	61..243	CDD:396096	70/186 (38%)
		PH_GRP1-like	258..378	CDD:269954
		C-terminal autoinhibitory region. /evidence=ECO:0000250	387..395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838931
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740