Protein Alignment garz and agef-1

DIOPT Version :9

• Sequence 1: NP_610761.2
• Gene: garz / 36337
• FlyBaseID: FBgn0264560
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001021798.2
• Gene: agef-1 / 173231
• WormBaseID: WBGene00012386
• Length: 1594
• Species: Caenorhabditis elegans
• Alignment Length: 1926
• Identity: 367/1926 - (19%)
• Similarity: 680/1926 - (35%)
• Gaps: 576/1926 - (29%)

  Fly    61 IEPQVFLAPFLEVIRTADATGP-LTSLALASVNKLLSYGLIDPTSPNLAD----IVERIADAVTH 120
            :|...:..|| |:  ..::..| :...||..:.||::||.:.....::::    :::||.:|:.
 Worm    74 VEADRYFLPF-EL--ACNSKSPKIVITALDCLQKLIAYGHLTGRGADISNPERKLIDRIVEAIC- 134

  Fly   121 ARFMGTDQSSDGVTFMRVIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEK 185
            |.|:|  |.:|....:::|:.:..::.|.. ..|...|:...:.:||.|....: |.:.:.:|:.
 Worm   135 APFLG--QGTDETVLLQLIKAVLAVVLSTH-CEVHGASLILAVRTCFNIYLTSK-SPINQATAKG 195

  Fly   186 SLKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRKSSAVEEPP 250
            :|..::...|..:.:|
 Worm   196 TLTQVINTVFGNMEKF------------------------------------------------- 211

  Fly   251 QTPQSANLTVPGHLKAPILATTPASPAGNILDMQGKITQTPTTTASTGEDETTVPETPVIQVEST 315
                                       |||.|                 |||.|.|...:.|.:|
 Worm   212 ---------------------------GNIKD-----------------DETIVREVVEVLVSNT 232

  Fly   316 ESEPLLDGETGEATSTLAEANSSEYINSVGVRFTQQSTDHDVTSLSPYGLPFIQE----LFRFLI 376
            .|..:.| ||.||..|..:..|:       :..::...|...|.::.|     |:    :||.|.
 Worm   233 ISNEVSD-ETSEAGGTHRQNGST-------MGESEAPLDDQFTFMNAY-----QKDAFLVFRALC 284

  Fly   377 ILCNPLDKQNSDSM----MHTGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLS 437
            ||....:...|:.|    ....|.:|.:..:.::..:...:..:.::|..||..|.....|..:.
 Worm   285 ILAQKEEGGASNEMSLRSKLLALEMLLLVLQNSSSILQSSQPCIIVIKRTLCMALTRNAVSNNIQ 349

  Fly   438 IFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEIIAS-DNPKTPYEMRELALDNLLQLWRIPGFV 501
            :|...|.:...|.:..:.|||..:|.:..  |.|:.. |:....:|.:.:.|:.:.::...|..|
 Worm   350 VFEKSLAIFVELLDKFKTHLKASIEVFFN--SVILPMLDSNTCAFEQKWIVLNTIGKILANPQSV 412

  Fly   502 TELYINYDCDLYCTDMFESLTNLLSKYTLSATN------------AVYSTHIISMDTLLSVIDSI 554
            .::::|||||:...::|:|:..::||.|.:..|            |:....:..:..||..:...
 Worm   413 VDMFVNYDCDMTSPNLFKSIVEVVSKTTRTTINENAPPAQKEKERAMRLLGLSCLTDLLQCLVDW 477

  Fly   555 ERNCAASKNSSNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINASSH 619
            .:.|...|.:|:    :.:|.|:.
 Worm   478 WQVCEVQKITSD----IDDAEPSE----------------------------------------- 497

  Fly   620 RLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFL 684
                |..||    |.|....:||:|.|:.||.:.|:::|:||:::|||||.:..  |.::||.|:
 Worm   498 ----QQHGE----TFEAFETLKQQKNLMEQGIQIFSEKPKKGLKFLQEHGFVGT--DAVEVAEFM 552

  Fly   685 RENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLE 749
            .:...|:|..:|:::......::.::..::|..||:.:.:..|||::||.|||||||..|..::.
 Worm   553 MKEERLNKTQVGDFLGDSDEFNNSVMHAYIDFLDFSSIDILAALRMFLEKFRLPGEAQKIDRLML 617

  Fly   750 HFSDHWHKQN--QDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGED 812
            .|:..:...|  |..||:.|||:.||::||||..|.||...|.   .||.:.:....||:|.|.:
 Worm   618 KFASRYLDCNPRQGIFASADAAYVLAFSIIMLTTDLHNKTVKN---KMTKQGYINMNRGINEGGN 679

  Fly   813 FDQEMLAQVFNAIKNEEIVMPAEQTGLVRE--------------------------NYQWKVLLR 851
            ...|:|..:|..|...||.|.|..|.|:|.                          :...:.|:.
 Worm   680 IPVELLEAIFEDISKNEIKMRAGATALLRSRVTPGQGALATDKERRAMAALEMEALSETARALME 744

  Fly   852 RGDTHDGHFHYVHDASYDVEIFNIVWGASLSALSF---MFDKSTETGYQRTLAGFSKSAAISAHY 913
            .....|.:|.......:...:|.|.|...|:|.|.   |.|...|  :...|.||......:...
 Worm   745 SASDADAYFTPAQHQHHVKPMFKICWTPCLAAFSVGVQMSDDEEE--WSLCLRGFRLGVRAACVL 807

  Fly   914 NLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCL 978
            ....:.:|.:..|.:||.|.:.....|....|.|               |::.:.|:..:.|:.|
 Worm   808 QATLERNAFIQALARFTLLTAKNSLGEMRVKNIE---------------AIKLLLLIGDEDGEYL 857

  Fly   979 RESWKHILDLYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEKPREKQESGLFSSLYSFISSEGQ 1043
            .|:|..::.....|..::|:...|         |.......:..|:          |...::.|.
 Worm   858 EENWVDVMKCMSSLELVQLIGTGL---------NSAMSHDTDSSRQ----------YVMKATGGI 903

  Fly  1044 REPT-YEEQDFIKLGRKCIKE--CQLDQMLQESKFVQLESLQELLKCVLALLKAPQGHKSIGLPY 1105
            .|.| :..||  .||....:.  ..:|::...|..:..|::...::.:.|:.:....|     |.
 Worm   904 DEKTLHSLQD--ALGETSSQSVVVAIDRIFNGSARLSAEAIVYFVRALCAVSREELSH-----PA 961

  Fly  1106 AEDQTVFWMEFLVKIVVHNRDRM----IPLWPAVRDQMYLLLMGSASCGYDYLLNRCIV-----A 1161
            |  ..:|.:..:|::..:|.:|:    ..:|..:.:.     ..:|.|.    .|..:.     |
 Worm   962 A--PRMFLLGKVVEVAFYNMNRIRLEWSRIWNVIGEH-----FNAAGCN----SNEAVAYFSVDA 1015

  Fly  1162 VLKLAIYLMRNEELCPI-----VLQSLKMLLMLKPA-----LLLRISKQISIGIYELLKTSAQNI 1216
            :.:|:|..:...||...     .|:..:::::...:     |::|....:.......||:..||:
 Worm  1016 LRQLSIKFLEKGELPNFRFQKDFLRPFEVIMVRNGSAQTRDLVVRCCAHLVEAHSSRLKSGWQNL 1080

  Fly  1217 HS-----------------------------EQDWQIIFN----LLECVGAGAVPPNYDDAQL-- 1246
            .|                             ::|:....:    .|:|:...|...|..|..:
 Worm  1081 FSVWTIAAGDPSTEIGEASFLTAQKVIEKRFKEDFPAFLDSFQEALKCLQEFACNQNQPDMNMEA 1145

  Fly  1247 --------PLPPNGSAKSDGAISGEEDATAVPERGYTSDSEITKASAAPAVSSPSAENWILVNNK 1303
                    ......|.|.|.|...::..    .:|.|:|..:......|.....|.    ::|..
 Worm  1146 IRLIRLCADYVSENSDKIDEAARRDDHL----HKGLTADQHVWLRGWFPIFFELSC----IINRC 1202

  Fly  1304 DSELTTASRPQSPPSLSAPPVNTLVYNCQLLDH-----APFALFKCWDSLAFIVRSVAHITPYNF 1363
            ..::.|.|               |....:::.|     .|    :.|..|..||
 Worm  1203 KLDVRTRS---------------LTVMFEIMKHHGSDFRP----EWWKDLLEIV----------- 1237

  Fly  1364 EACVRCIRIFVEACRDGGIRQRRKLESAAKQKSSKKRSERKPGMASSASSSNLTLLTGDPSDNQI 1428
                  .|||                  ...|....||:::..|:::.:.:.|:::
 Worm  1238 ------FRIF------------------DPSKMDDHRSDKREWMSTTCNHAMLSVV--------- 1269

  Fly  1429 NGNAAEQEDLAQRYEQLSIQLLDLMYTLY-----TRTAQIFRWWAEEGCTVPQSAALWSPGWCPL 1488
                   |...|.|.|||:..|.::|..:     .:..|:.|      ||
 Worm  1270 -------EVFTQFYTQLSVYALPMIYRQFGIFIRQQNEQLAR------CT--------------- 1306

  Fly  1489 LQGIARLAMDRRREVRTHAISCLQQRALLVHDLQTLSGTEWCSCFHQVLFPLLNELL-------- 1545
                               ||||:       .|.:.:|..:.....:....|:.||.
 Worm  1307 -------------------ISCLE-------SLISQNGERFTEPMWEQTIELIRELFETTLPKSL 1345

  Fly  1546 -----PESNAAGQLDAALLEESRIRTATIMSKVFLQHLTTLIELGNAFNELWLDILDYIERFMKV 1605
                 |.||..|       .|.|...:..:|...:.......||..|.:.:.|.  |:.|....:
 Worm  1346 LTWEPPNSNGIG-------SEDRTNGSDTLSSEQIVFCVVQNELVEAVSRIVLG--DHRESKRDL 1401

  Fly  1606 GSDTLSEQM--QEILK--NMLLVMHSV-RVFHNQDGSLQQALWELTWRRIGEFLPNLKEE----- 1660
            ..|.|..||  |.:|.  :.|...|:: :.|:|.:|. :..:|:.  |.:|...|||..:
 Worm  1402 QIDGLFTQMSPQLLLSICDALAESHTLAKQFNNNNGQ-RVLIWKA--RLLGSTKPNLINQETRSL 1463

  Fly  1661 ---------LFHDEGKRAQTLTNPAPQAAVAAAPQQQLPAVTILPRQTQVSNELVVSAPTPPAAT 1716
                     |.:|  .|||::::..              |:.:|        |:|..|
 Worm  1464 SAMLAILFRLLYD--LRAQSISDKI--------------AIRVL--------EVVSLA------- 1497

  Fly  1717 PLLG-SPVESPRRSIILQPPMADVLQQ----PPSFVFAQPIIVPPQPPAVTDPIPPS--TLLPDL 1774
             |.| ...||..|.....|.:.::|::    |.:.:   |::.|..|..:.|.:..:  ..:..|
 Worm  1498 -LSGYGEAESDTRRTAYGPVICELLRECIALPTNLI---PVLGPEFPLKLCDLVETAEDQTMRKL 1558

  Fly  1775 VNEATAAAVQATTTSPTHSPQEAEQPASIVQQTNIVTTNNT 1815
            :.|.....:...|.||| :.|||.:.:    |.:.::.|.|
 Worm  1559 LAELFRRIINFQTKSPT-TVQEALEES----QKSHISENFT 1594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	171/768 (22%)
		Sec7_N	370..512	CDD:289549	32/150 (21%)
		Sec7	643..830	CDD:279680	64/188 (34%)
agef-1	NP_001021798.2	PLN03076	18..1476	CDD:215560	334/1766 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920