DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and Psd

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_599197.2	Gene:	Psd / 171381	RGDID:	620297	Length:	1023	Species:	Rattus norvegicus

Alignment Length:	943	Identity:	194/943 - (20%)
Similarity:	313/943 - (33%)	Gaps:	292/943 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 GHLKAPILATTP---ASPAGNILDMQGKITQTPTTTASTGEDETTVP-----ETPVIQV------ 312
            |.|..|.....|   |.|:..:...||...........:..|...||     ||.:.:|
  Rat   244 GSLDPPSSGAKPPEQALPSHGVGSKQGSGVAVGRAAKYSETDLDKVPLRCYRETDIDEVLAEREE 308

  Fly   313 --ESTESEPLLDGETGEA-------------TSTLAEANSSEYINSVGVRFTQQSTDHDVTSLSP 362
              .:.||:|..:|..|..             :|:|...|..:....      ::..|.:|...|.
  Rat   309 ADSAIESQPSSEGPPGTTQPPASRPSPCPGPSSSLGSGNGDDEAGG------EEDVDDEVFEASE 367

  Fly   363 YGLPFIQELFRFLIILCNPLDKQNSDSMMHTGLSLLTVAF----EVAADNIGKYEGLLELVKDDL 423
            ...|                    .|.|.|:||....|.|    ..:||....:..:.|.:.:..
  Rat   368 GARP--------------------GDHMPHSGLLKSPVPFLPGTSPSADGPDSFSCMFEAIMESH 412

  Fly   424 CRNLISLLSSERLSIFAA--DLQLCFLLFESLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMREL 486
            .....|..|...|...|:  ..|..|..||     :..|..|         ...:|..|..:..|
  Rat   413 RAKGTSYSSLASLEALASPGPTQSPFFTFE-----MPPQPPA---------PRPDPPAPAPLAPL 463

  Fly   487 ALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTLSATNAVYSTHIISMDTLLSVI 551
            ..|                                         |.|::|       .|...:..
  Rat   464 EPD-----------------------------------------SGTSSV-------ADGPWTQR 480

  Fly   552 DSIERNCAASKNSSNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINA 616
            ..:|.:.|.:..:.  |:.||..:       ||..:.||....:  |:.....:.|.:..|.::
  Rat   481 REVEESDAGATLAP--RKELPSPS-------HSEDSLGLGAAPL--GSEPPLSQLVSDSDSELD- 533

  Fly   617 SSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVA 681
            |:.||.|   |....:::.|.|.::..:||            .|.:..|.  |...|:     ||
  Rat   534 STERLAL---GSTDTLSNGQKADLEAAQRL------------AKRLYRLD--GFRKAD-----VA 576

  Fly   682 LFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFL 746
            ..|.:|....|.:.|||:.               .|.|||:.:|||||::|:...|.||......
  Rat   577 RHLGKNNDFSKLVAGEYLK---------------FFVFTGMTLDQALRVFLKELALMGETQERER 626

  Fly   747 VLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQHNSN-AKRLNVPMTLEDFTKNLRGLNGG 810
            ||.|||..:.:.|.:..::.|.|..|..|:::||.|.|..| .||    ||..||..||.|||.|
  Rat   627 VLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKR----MTCGDFIGNLEGLNDG 687

  Fly   811 EDFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFNI 875
            .||.:|:|..::::||||::              ||.:     |..:........|..:.::...
  Rat   688 GDFPRELLKALYSSIKNEKL--------------QWAI-----DEEELRRSLSELADPNPKVIKR 733

  Fly   876 VWGASLSALSFMFDKSTETGYQRTLAGFSKSAAISAH----YNLHSDFDALVLTLCKFT------ 930
            |.|.|.|:.|...|.:.|.|           ||:..|    ..:|:|.|      |:.|
  Rat   734 VSGGSGSSSSPFLDLTPEPG-----------AAVYKHGALVRKVHADPD------CRKTPRGKRG 781

  Fly   931 -----------TLLSSVEQHEPAPANNETQQ----AVNFGLNGKAQAAMR---TVFLLVHDYGDC 977
                       .|....|:::|..|.:|.:.    :::..|..:|....:   ..:|...|:...
  Rat   782 WKSFHGILKGMILYLQKEEYQPGKALSEAELKNAISIHHALATRASDYSKRPHVFYLRTADWRVF 846

  Fly   978 L--------RESWKHILDLYLQLFRLKLLPKSLIEVEDFC--------------------EANGK 1014
            |        .:||...:::...:|.....|.::...:.|.                    ||..|
  Rat   847 LFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLK 911

  Fly  1015 AMLILEKPREKQESGLFSSLYSFISSEGQREPTYEEQD---------FIKLGRKCIKECQLDQML 1070
            ||  ..:.||.:.:.|........:.|.:::.||.|.:         .:::..|...| :||.:
  Rat   912 AM--ASELREHRAAHLGKKARGKEAEEQRQKETYLEFEKSRYGTYAALLRVKMKAASE-ELDAI- 972

  Fly  1071 QESKFVQLESLQELLKCVLALLKAPQGHKSIGL 1103
             |:...|..|.:|         ..|..|.|..|
  Rat   973 -EAALAQAGSTEE---------GCPPPHSSPSL 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	161/787 (20%)
		Sec7_N	370..512	CDD:289549	24/147 (16%)
		Sec7	643..830	CDD:279680	62/187 (33%)
Psd	NP_599197.2	Sec7	541..707	CDD:238100	65/203 (32%)
		PH_EFA6	752..876	CDD:270107	22/140 (16%)
		PH	756..864	CDD:278594	18/113 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900