DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment garz and Cyth1

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_446362.1	Gene:	Cyth1 / 116691	RGDID:	620397	Length:	398	Species:	Rattus norvegicus

Alignment Length:	247	Identity:	87/247 - (35%)
Similarity:	141/247 - (57%)	Gaps:	17/247 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   599 NSVAAEEK--VENI---ASFINASSHRLR-----LQSGGEGVGITSEQLAKVKQKKRLLSQGTER 653
            :.:.|||:  :|||   ...:.|...||:     :.:..|.:|.|.|:  |..|:.:.::.|.::
  Rat    10 SDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEER--KNMQRNKQVAMGRKK 72

  Fly   654 FNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFD 718
            ||..|:||||:|.|:|:|....:  .:|.||.:..||:|..||:|:.::.....::|..||:..:
  Rat    73 FNMDPKKGIQFLIENGLLKNTCE--DIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHE 135

  Fly   719 FTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQ 783
            ||.|.:.||||.:|.:|||||||..|..::|.|:..:.:.|...|.:.|..:.|::||||||...
  Rat   136 FTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSL 200

  Fly   784 HNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPAE 835
            ||.|.|  :.| |:|.|....||:|.|.|..:|:|..::.:||||...:|.:
  Rat   201 HNPNVK--DKP-TVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPED 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	87/247 (35%)
		Sec7_N	370..512	CDD:289549
		Sec7	643..830	CDD:279680	71/186 (38%)
Cyth1	NP_446362.1	Sec7	62..244	CDD:307500	71/186 (38%)
		PH_GRP1-like	259..379	CDD:269954
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250	269..277
		C-terminal autoinhibitory region. /evidence=ECO:0000250	388..396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810