DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and Gbf1

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_006526643.1	Gene:	Gbf1 / 107338	MGIID:	1861607	Length:	1862	Species:	Mus musculus

Alignment Length:	1933	Identity:	829/1933 - (42%)
Similarity:	1135/1933 - (58%)	Gaps:	234/1933 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IYVVRGEMATLMTAMRRGTRWNATAYVDDENDSLLKLFIDLKHELNRIEDLRQIEPQVFLAPFLE 72
            ||:::||:..::.|::|..||:....:|:|.|.||..|.:||..||.:.:|.:|||.|||.||||
Mouse     6 IYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFSNLKEVLNSVTELSEIEPNVFLRPFLE 70

  Fly    73 VIRTADATGPLTSLALASVNKLLSYGLIDPTSPNLADIVERIADAVTHARFMGTDQSSDGVTFMR 137
            |||:.|.|||:|.|||.||||.|||.|||||....|:.:|.:|||||||||:|||.:||.|..|:
Mouse    71 VIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMADAVTHARFVGTDPASDEVVLMK 135

  Fly   138 VIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMRLPQFA 202
            :::||.||:.:|.|..::|.|:||:|.|||:|.||.|||||||:|||.:|.|||.|.|.|||||.
Mouse   136 ILQVLRTLLLTPVGTHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFK 200

  Fly   203 EERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRKSSAVEEPPQTPQSANLTVPG-HLKA 266
            ||....:            |...:|||.:....:.::..|..  :..|:.|:......|| .|..
Mouse   201 EEPKSYV------------GTNMKKLKMRAGGMSDSSKWKKQ--KRSPRPPRHTTKVTPGSELPT 251

  Fly   267 PILATTPASPAGNI--LDMQGKITQTPTTTASTG-----------EDETTVPE--TPVIQV---- 312
            |..||.|::..|.:  :|....|:...:..|||.           ..:||..|  |.:.|.
Mouse   252 PNGATLPSNLTGGVPFIDAPTSISSASSEAASTVVSPCTDSGLELSSQTTSKEDLTDLEQAGSPR 316

  Fly   313 ESTESEP---------------------------------LLDGETGEAT-STLAEANSSEYINS 343
            |.|.|||                                 :|:..|..|. |..|..:..:|:|.
Mouse   317 EITTSEPGSSEMGASDQLDPQQEGAHVEKAQSASVESIPEVLEECTSPADHSDSASVHDMDYVNP 381

  Fly   344 VGVRFTQQSTDHDVTSLSPYGLPFIQELFRFLIILCNPLDKQNSDSMMHTGLSLLTVAFEVAADN 408
            .||||| ||:..:.|:|.|||||.|:|||||||.|.||.|:.||:.|:|.||.|||||.|.|.
Mouse   382 RGVRFT-QSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAP-- 443

  Fly   409 IGKYEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEIIA 473
            :.:.:.||.|:||::||:|..|||.|||:::||.|::|||||||:|.|||||||.|::||.|||.
Mouse   444 VAQCQTLLGLIKDEMCRHLFQLLSVERLNLYAASLRVCFLLFESMREHLKFQLEMYIKKLMEIIT 508

  Fly   474 SDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTLSATNAVYS 538
            .:|||.||||:|:||:.::||||||.||||||||||||.||:::||.||.||||.....:..:|:
Mouse   509 VENPKMPYEMKEMALEAVVQLWRIPSFVTELYINYDCDYYCSNLFEDLTKLLSKNAFPVSGQLYT 573

  Fly   539 THIISMDTLLSVIDSIERNCAASKNSSNNRESLPEAA----------PATGGSRHSRHNSGLEGI 593
            ||::|:|.||:||||.|.:|.|...::.|::...|.|          |.|..|..:..:....|:
Mouse   574 THLLSLDALLTVIDSTESHCQAKVLNTLNQQEKKETARPGFEAVDGNPETNKSERATSDGKSTGV 638

  Fly   594 VID-------SGNSVAAEEKVENIASFINASSHRLRLQSGGEGVGITSE------------QLAK 639
            .:|       ||..::.|...........|.       ..|.....|.:            :|.:
Mouse   639 ALDARGLHFPSGGWLSTEHGKPGCRDLEEAG-------DSGADKKFTRKPPRFSCLLPDPRELIE 696

  Fly   640 VKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIGEYISKKKN 704
            :|.||:||..|||:|||:|:||||:|||.|:|...:|..:||.:|||||.||||||||::|.:||
Mouse   697 IKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDRKN 761

  Fly   705 VDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQDPFANVDAA 769
            :|  :|.:||.:|.|.|||:|:|||||||.||||||||:|..:||.|::||...|..||||.||.
Mouse   762 MD--LLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIHRLLEVFTEHWRSCNGSPFANSDAC 824

  Fly   770 FRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPA 834
            |.||||:||||.||||.|.::.|.|||||:|.|||:|:|||:||:|::|..:::||||||||||.
Mouse   825 FALAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPE 889

  Fly   835 EQTGLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFNIVWGASLSALSFMFDKS-TETGYQR 898
            ||||||||||.|.|||.||.:.:|.|..|...|||:::|.:.||.:::|||::|||| .||..|:
Mouse   890 EQTGLVRENYVWSVLLHRGASPEGVFLRVPPGSYDLDLFTMTWGPTIAALSYVFDKSLEETIIQK 954

  Fly   899 TLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNETQQAVNFGLNGKAQAA 963
            .::||.|.|.|||||.|...||.|:::|||||.|.|...::.|:.          ||.|.||..|
Mouse   955 AISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPSV----------FGSNPKAHIA 1009

  Fly   964 MRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEK-PREKQE 1027
            .:|||.|.|.:||.|||.||:|::..|||||.:||||:::|||||.:.|||..|..|: |..:.|
Mouse  1010 AKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMVEVEDFVDPNGKISLQREETPSNRGE 1074

  Fly  1028 SGLFSSLYSFIS--------SEGQREPTYEEQDFIKLGRKCIKECQLDQMLQESKFVQLESLQEL 1084
                |::.||:|        ....|.|:.|.|:..::...|||:|..::|:.||||:||||||||
Mouse  1075 ----STVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALDCIKQCDPEKMITESKFLQLESLQEL 1135

  Fly  1085 LKCVLALLKAPQGHKSIGLPYAEDQTVFWMEFLVKIVVHNRDRMIPLWPAVRDQMYLLLMGSASC 1149
            :|.::::....:       .|.|:...|.:|.|::||:.||||:..:|..|||.:|.|.:.:..
Mouse  1136 MKALVSVTPDEE-------TYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQD- 1192

  Fly  1150 GYDYLLNRCIVAVLKLAIYLMRNEELCPIVLQSLKMLLMLKPALLLRISKQISIGIYELLKTSAQ 1214
             :.:|:.|.:|.:|:|||.|:|.||:...||.||::||::||::|.|:|.|::.|::|||||:|.
Mouse  1193 -FCFLVERAVVGLLRLAIRLLRREEISGQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAA 1256

  Fly  1215 NIHSEQDWQIIFNLLECVGAGAVPPNYDDAQLPL-PPNGSAKSDGAISGEEDATAVPERGYTSDS 1278
            ||||..||..:|.||||:|:|..||:...|.... .|:..|:||..:..........:|||||||
Mouse  1257 NIHSGDDWATLFTLLECIGSGVKPPDALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDS 1321

  Fly  1279 EITKASAAPAVSSPSA-------ENWILVNNKDSELTTASRPQSPPSLSAPPVN--TLVYNCQLL 1334
            |:......|.....||       ..|::|...|.:.:......|.|..| |.||  :|.....|.
Mouse  1322 EVYTDHGRPGKIHRSATDADMVNSGWLVVGKDDIDNSKPGAGLSRPGPS-PLVNQYSLTVGLDLG 1385

  Fly  1335 DHAPFALFKCWDSLAFIVRSVAHITPYNFEACVRCIRIFVEACRDGGIRQRRKLESAAKQKSSKK 1399
            .|...:|.||.:||:||||..|||||.|||.||:.:||||||..:||.:.:.|...:.|..|...
Mouse  1386 PHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQDKRSKSHKYDSKGN 1450

  Fly  1400 RSERKP---GMASSASSSNLTLLTGDPSDNQINGNAAEQEDLAQRYEQLSIQ----LLDLMYTLY 1457
            |.::||   .|......||.....|..||.:      |.|.:...|..:|:|    |||||:||:
Mouse  1451 RFKKKPKEGSMLRRPRGSNQHATRGGHSDEE------EDEGVPASYHTVSLQVSQDLLDLMHTLH 1509

  Fly  1458 TRTAQIFRWWAEE-------GCTV-PQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQR 1514
            ||.|.|:..||||       |..: ..|..||:..|||||||||.|..|.||:||..|::.| ||
Mouse  1510 TRAASIYSSWAEEQRHLEGGGQKIEADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYL-QR 1573

  Fly  1515 ALLVHDLQTLSGTEWCSCFHQVLFPLLNELLPESNAAGQLDAALLEESRIRTATIMSKVFLQHLT 1579
            ||||||||.|...||.|||::||||||.:||...:.|   |...:||:|:|.:|::||||||||:
Mouse  1574 ALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPA---DVGGMEETRMRASTLLSKVFLQHLS 1635

  Fly  1580 TLIELGNAFNELWLDILDYIERFMKVG-SDTLSEQMQEILKNMLLVMHSVRVFHNQD--GSLQQA 1641
            .|:.| :.|..|||.|||:::::|..| ||.|||.:.|.||||||||.:..:||:.|  |....|
Mouse  1636 PLLSL-STFAALWLTILDFMDKYMHAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSA 1699

  Fly  1642 LWELTWRRIGEFLPNLKEELFHDEGKRAQTLTNPAPQAAVAAAPQQQLP-AVTIL---------- 1695
            |||:||.||..|||:|::|||     :...:.:|.|     |.|..|.| |.|.|
Mouse  1700 LWEITWERIDCFLPHLRDELF-----KQTVIQDPMP-----AEPHSQKPLASTHLTSAAGDPRMP 1754

  Fly  1696 --PRQTQVSNELVV-------SAPTPPAATPLLGSPV-ESPRRSIILQ---PPMADVLQQPPSFV 1747
              |...::.:|:.|       |...|.:::|  |||: .||.:....|   ||    |.|||  :
Mouse  1755 GHPPLPEIPSEMGVCDSEKPESTRAPSSSSP--GSPMASSPSKLSPAQEGPPP----LTQPP--L 1811

  Fly  1748 FAQPIIVPPQPPAVTDPIPPSTLLPDLVN----EATAAAVQATTTSPT 1791
            ..||:..|.|.     .:||.| ||.::|    |||:......|..||
Mouse  1812 ILQPLTSPLQV-----GVPPMT-LPIILNPALIEATSPVPLLATPRPT 1853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	368/754 (49%)
		Sec7_N	370..512	CDD:289549	89/141 (63%)
		Sec7	643..830	CDD:279680	114/186 (61%)
Gbf1	XP_006526643.1	Sec7_N	401..546	CDD:372313	92/146 (63%)
		COG5307	484..>1003	CDD:227623	263/537 (49%)
		Sec7	700..885	CDD:366596	114/186 (61%)
		PHA03247	<1730..1860	CDD:223021	42/143 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838944
Domainoid	1	1.000	639	1.000	Domainoid score	I166
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37897
Inparanoid	1	1.050	1349	1.000	Inparanoid score	I142
Isobase	1	0.950	-	0	Normalized mean entropy	S3208
OMA	1	1.010	-	-		QHG55524
OrthoDB	1	1.010	-	-		D49474at33208
OrthoFinder	1	1.000	-	-		FOG0003083
OrthoInspector	1	1.000	-	-		oto94292
orthoMCL	1	0.900	-	-		OOG6_102130
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2128
SonicParanoid	1	1.000	-	-		X2055
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750