DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and ARFGEF1

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_006412.2	Gene:	ARFGEF1 / 10565	HGNCID:	15772	Length:	1849	Species:	Homo sapiens

Alignment Length:	1854	Identity:	370/1854 - (19%)
Similarity:	654/1854 - (35%)	Gaps:	541/1854 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 IEPQVFLAPFLEVIRTADATGPLTSLALASVNKLLSYGLI-----DPTSPNLADIVERIADAVTH 120
            ||...:..||  .:........:.|.:|..:.||::||.:     |.|:|. ..:::||.:.:..
Human    75 IEADKYFLPF--ELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPG-KKLIDRIIETICG 136

  Fly   121 ARFMGTDQSSDGVTFMRVIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEK 185
            . |.| .|:.:||. :::|:.|.|.:.| :...:...::.:.:.:|:.|....: :.:.:.:|:.
Human   137 C-FQG-PQTDEGVQ-LQIIKALLTAVTS-QHIEIHEGTVLQAVRTCYNIYLASK-NLINQTTAKA 196

  Fly   186 SLKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRKSSAVEEPP 250
            :|..|:.:.|.|:...|.:.:..|.::|.        .....|.:..|:..:  |........||
Human   197 TLTQMLNVIFARMENQALQEAKQMEKERH--------RQHHHLLQSPVSHHE--PESPQLRYLPP 251

  Fly   251 QTPQSANLTVPGHL-------KAPILATTPASPAGNILDMQGKITQTPTTTAS----------TG 298
            ||....:....|.|       ...:...|......:|...:.:.|:....||:          .|
Human   252 QTVDHISQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDG 316

  Fly   299 EDETTVPETP--VIQVESTESEPLLDGETGEATS----------TLAEANSSEYINSVGV----- 346
            |:. ...|.|  ::|....|...::.|:.||.|:          |:.:.:.||.|.:.|:
Human   317 ENH-DCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGTIEDGSDSENIQANGIPGTPI 380

  Fly   347 -----------RFTQQSTDHDVTSLSPYGLP-----FIQELFRFLII--LC----NPLDKQNSDS 389
                       |.:..|.|...:..|....|     .|.:...||:.  ||    .||.....|.
Human   381 SVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDP 445

  Fly   390 MMH------TGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFL 448
            ..|      ..|.||....:.|.......|..:..:|..||..|.....|....:|...|.:...
Human   446 KSHELRSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLT 510

  Fly   449 LFESLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLY 513
            |..:.:.|||.|:|.:.:::...|. :...:.::.:.:.:..|.::......|.::|:||||||.
Human   511 LLSNFKTHLKMQIEVFFKEIFLYIL-ETSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLN 574

  Fly   514 CTDMFESLTNLLSKYT-------LSATNA-VYSTHIISMDTLLSVIDSIERNCAA--SKN---SS 565
            ..::||.|.|.|||..       |..:|. ..|.....::.|:|::     .|..  ||:   :.
Human   575 AANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSIL-----KCMVEWSKDQYVNP 634

  Fly   566 NNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINASSHRLRLQSGGEGV 630
            |::.:|.:..|:.......:|                 .|.:....|..:..|      :...|:
Human   635 NSQTTLGQEKPSEQEMSEIKH-----------------PETINRYGSLNSLES------TSSSGI 676

  Fly   631 GITS---------EQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRE 686
            |..|         ||...:||:|.::.||.:.||::|::|||||||.|:|..  .|..:|.||.:
Human   677 GSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGT--TPEDIAQFLHQ 739

  Fly   687 NPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHF 751
            ...||...:||::......:.:::..:||..||:|.....|||::||.|||||||..|..::|.|
Human   740 EERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKF 804

  Fly   752 SDHWHK--QNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFD 814
            :..:.:  |.|..||:.|.|:.|||:||||..|.|:...|.   .||.|.:.|..||:|..:|..
Human   805 AARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKN---KMTKEQYIKMNRGINDSKDLP 866

  Fly   815 QEMLAQVFNAI--------KNEEIVMP---------AEQTGLVRENYQWKVLLRRGD-------- 854
            :|.|:.::|.|        :.:|:.:|         :|:...:..|.:.:.:.:...
Human   867 EEYLSAIYNEIAGKKISMKETKELTIPTKSSKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSH 931

  Fly   855 -----THDGHFHYVHDASYDVEIFNIVWGASLSALSFMFDKSTETGY-QRTLAGFSKSAAISAHY 913
                 |...|..:|.      .:|.:.|...|:|.|.......:|.. ...|.|...:..|:..:
Human   932 VQAPFTSATHLEHVR------PMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIF 990

  Fly   914 NLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCL 978
            ::..:.||.|..|.:||.|..|....|....|.:|               ::|:..:.|..|:.|
Human   991 SIQLERDAYVQALARFTLLTVSSGITEMKQKNIDT---------------IKTLITVAHTDGNYL 1040

  Fly   979 RESWKHILDLYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEKPREKQESGLFSSLYSFISS--- 1040
            ..||..||....||...:|:...:                  |||             :||.
Human  1041 GNSWHEILKCISQLELAQLIGTGV------------------KPR-------------YISGTVR 1074

  Fly  1041 --EGQREPTYEE--QDFIKLGRKCIKECQLDQMLQESKFVQLESLQELLKCVLALLKAPQGHKSI 1101
              ||....|.::  .:|:.||   :....:|       :.|:.|:||                ||
Human  1075 GREGSLTGTKDQAPDEFVGLG---LVGGNVD-------WKQIASIQE----------------SI 1113

  Fly  1102 GLPYAEDQTVFWMEFLVKIVVHNRDRMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLA 1166
            |            |...:.||...||:.                   .|...|....||..::.
Human  1114 G------------ETSSQSVVVAVDRIF-------------------TGSTRLDGNAIVDFVRW- 1146

  Fly  1167 IYLMRNEELCPIVLQSLKMLLMLKPALLLRISKQISIGIYELLKTSAQNIHSEQDWQII---FNL 1228
                    ||.:   |:..||......:..:.|.:.|..|.:.:...|   ..:.|::|   ||.
Human  1147 --------LCAV---SMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQ---WSRIWEVIGDHFNK 1197

  Fly  1229 LECVGAGAVPPNYDDAQLPLPPNGSAKSDGAISGEEDATAVPERGYTSDSEITKASAAPAVSSPS 1293
            :.|      .||.|.|...:.           |..:.:....|:|..::....|....|.
Human  1198 VGC------NPNEDVAIFAVD-----------SLRQLSMKFLEKGELANFRFQKDFLRPF----- 1240

  Fly  1294 AENWILVNNKDSELTTASRPQSPPSLSAPPVNTLVYNC--QLLDHAPFALFKCWDS--------- 1347
              ..|:..|:                 :|.:..:|..|  |:::.....:...|.:
Human  1241 --EHIMKRNR-----------------SPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAA 1286

  Fly  1348 ---------LAFIVRSVAHI-----------TPYNFEACVRCIRIFVEACR----DGGIRQRRKL 1388
                     |||  ::..||           |..:|:..|:|:..|  ||.    |..:...|.:
Human  1287 SDQDESIVELAF--QTTGHIVTLVFEKHFPATIDSFQDAVKCLSEF--ACNAAFPDTSMEAIRLI 1347

  Fly  1389 ESAAKQKSSKKRSERKPGMASSASSSNLTLLTGDPSDNQINGNAAEQEDLAQRYEQLSIQLLDLM 1453
            ...||..|.:
Human  1348 RHCAKYVSDR------------------------------------------------------- 1357

  Fly  1454 YTLYTRTAQIFRWWAEEGCTVPQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQRALLV 1518
                   .|.|:.:..:...|.....:|..||.|:|..::.:....:.:|||..::      ::.
Human  1358 -------PQAFKEYTSDDMNVAPEDRVWVRGWFPILFELSCIINRCKLDVRTRGLT------VMF 1409

  Fly  1519 HDLQTLSGT---EWCSCFHQVLFPLLNEL-LPESNAAGQLDAALLEESRIRTAT------IMSKV 1573
            ..::|...|   .|.....:::|.:.:.: |||...         |::...|.|      .:..|
Human  1410 EIMKTYGHTYEKHWWQDLFRIVFRIFDNMKLPEQQT---------EKAEWMTTTCNHALYAICDV 1465

  Fly  1574 FLQHLTTL--IELGNAFNELWLDILDYIERFMKVGSDTLSEQMQEILKNMLLVMHSVRVFHNQDG 1636
            |.|:|..|  :.|.:.|.:|:..:....|:..:.|::.|               .:|.:.:.:..
Human  1466 FTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSGTNCL---------------ENVVILNGEKF 1515

  Fly  1637 SLQQALWE------------------LTWRRIGEFLPNLKEELFHDEGKRAQTLTNPAPQAAVAA 1683
            :|:  :|:                  ||||      ||..|             |.|.|     .
Human  1516 TLE--IWDKTCNCTLDIFKTTIPHALLTWR------PNSGE-------------TAPPP-----P 1554

  Fly  1684 APQQQLPAVTILPRQTQVSNEL----VVSAPTPP 1713
            :|..:.|..||..:...:.:.:    |.:.|..|
Human  1555 SPVSEKPLDTISQKSVDIHDSIQPRSVDNRPQAP 1588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	191/810 (24%)
		Sec7_N	370..512	CDD:289549	34/153 (22%)
		Sec7	643..830	CDD:279680	71/196 (36%)
ARFGEF1	NP_006412.2	DCB, DCB:DCB domain and DCB:HUS domain interaction	2..224		33/156 (21%)
		PLN03076	15..1766	CDD:215560	370/1854 (20%)
		DCB	29..210	CDD:292830	31/142 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..65
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..248		5/41 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..302		4/37 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..413		5/34 (15%)
		Sec7_N	419..573	CDD:289549	34/154 (22%)
		HUS, DCB:HUS domain interaction	557..577		8/19 (42%)
		Sec7	698..882	CDD:279680	71/188 (38%)
		Nuclear localization signal (NLS)	711..715		1/3 (33%)
		DUF1981	1220..1301	CDD:286414	14/106 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1543..1562		8/42 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148844
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750