Protein Alignment garz and arfgef2

DIOPT Version :9

• Sequence 1: NP_610761.2
• Gene: garz / 36337
• FlyBaseID: FBgn0264560
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_002933226.3
• Gene: arfgef2 / 100492055
• XenbaseID: XB-GENE-6041969
• Length: 1792
• Species: Xenopus tropicalis
• Alignment Length: 1798
• Identity: 379/1798 - (21%)
• Similarity: 643/1798 - (35%)
• Gaps: 545/1798 - (30%)

  Fly    61 IEPQVFLAPFLEVIRTADATGP-LTSLALASVNKLLSYGLIDPTSPNLA----DIVERIADAVTH 120
            ||...:..|| |:  ......| :.|.:|..:.||::||.|...:|:..    .:::||.|.:..
 Frog    67 IEADKYFLPF-EL--ACQLKSPRVVSTSLDCLQKLIAYGHITGNAPDKGAPGKRLIDRIVDTICS 128

  Fly   121 ARFMGTDQSSDGVTFMRVIEVLHTLIRSP-----EGAAVSNVSMCEVMLSCFKISFEPRLSELLR 180
            . |.| .|:.:||. :::|:.|.|::..|     ||..:..|.      :|:.|....: :.:.:
 Frog   129 C-FQG-PQTDEGVQ-LQIIKALLTIVTCPFVEIHEGTILHTVR------TCYNIYLASK-NLVNQ 183

  Fly   181 RSAEKSLKDMVLLFFMRLP-QFAEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAP---- 240
            .:|:.:|..|:.:.|:|:. |..:|:.:.::|             .:|:......:|..:|
 Frog   184 TTAKATLTQMLNVIFIRMENQALQEQQEYVIQ-------------HQKIHSPVPYRAMGSPNLKH 235

  Fly   241 -RKSSAVEEPPQTPQSANLTVP--GHLKAPILATTPASPAGNI---LDMQGKITQTPTTTASTGE 299
             ..:..:.|.| .|.:.|.|.|  |...|.....|..:.:.|:   ::...:|:....|.|...|
 Frog   236 KNNNHLLNELP-VPGNDNSTNPEQGMEAAEGNEHTEGADSCNVTTDVESVSEISANEETPADIIE 299

  Fly   300 DET-----------TVPETPVIQVESTESEPLL-------------DGETGEATSTLAEANSSEY 340
            |.|           .|.|....:.||.:..|.|             ||::..:|..| |::|...
 Frog   300 DTTDSVCKEQEEREAVDEAATSEAESGDLPPTLNLPESIQTNGISDDGQSISSTDNL-ESDSLHG 363

  Fly   341 INSVGVRFTQQSTDHDVTSLSPYGLPFIQELFRFLII--LC----NPLDKQNSDSMMH------T 393
            .|| |.:|:.                 |.:...||:.  ||    .||.:...|...|      .
 Frog   364 QNS-GAKFSH-----------------ILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKII 410

  Fly   394 GLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLRGHLK 458
            .|.||....:.|......:|..:..:|..||..|.....|....:|...|.:...|....:.|||
 Frog   411 SLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLALLSHFKMHLK 475

  Fly   459 FQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTN 523
            .|:|.:.:::...|. :...:.:|.:.:.:..|.::......|.::|:||||||...::||.|.|
 Frog   476 MQVEVFFKEIFLNIL-ETSSSSFEHKWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVN 539

  Fly   524 LLSKYTLSATNAVYSTHIISM-------------DTLLSVI-------------DSIERNCAASK 562
            .|||.....     |.|.:.|             :.|:|::             .:.:.|....|
 Frog   540 DLSKIAQGR-----SGHELGMTPTQELCLRKKGLECLVSILKCMVEWSKDLYVNPNFQSNLGQEK 599

  Fly   563 NSSNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINASSHRLRLQSGG 627
            ||  :.||.....|.|.|.|:|          :.|.:|..:
 Frog   600 NS--DPESCENKTPETTGRRYS----------VSSKDSTVS------------------------ 628

  Fly   628 EGVGITS---------EQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALF 683
            .|:|.||         ||...:||:|.::..|.|.||::|::|:|||||.|:|...  |..:|.|
 Frog   629 SGIGSTSTQTSIPDDPEQFEVIKQQKEIIEHGIELFNKKPKRGMQYLQEQGMLGTM--PQDIAQF 691

  Fly   684 LRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVL 748
            |.:...||...|||::.:....:.:::..:||..||.......|||::||.|||||||..|..::
 Frog   692 LHQEDRLDFTQIGEFLGENNRFNREVMYAYVDQLDFCDKDFVSALRMFLEGFRLPGEAQKIDRLM 756

  Fly   749 EHFSDHWHK--QNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGE 811
            |.|:..:.:  |.|..||:.|.|:.|||:||||..|.|:...|.   .||.|.:.|..||:|..:
 Frog   757 EKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKN---KMTKEQYIKMNRGINDSK 818

  Fly   812 DFDQEMLAQVFNAIKNEEIVM-----------------PAEQTGLVRENYQWKVLLRRGD----- 854
            |..:|.|:.:::.|:.::|.|                 .:|:...:..|.:.:.:.:...
 Frog   819 DLPEEYLSSIYDEIEGKKIAMKETKEHTIATKSTKPSVASEKQRRLLYNMEMEQMAKTAKALMEA 883

  Fly   855 --------THDGHFHYVHDASYDVEIFNIVWGASLSALSF-MFDKSTETGYQRTLAGFSKSAAIS 910
                    |...|..:|.      .:|.:||...|:|.|. :.|..........|.|...:..||
 Frog   884 VSHAKAQFTSATHLDHVR------PMFKLVWTPLLAAFSIGLQDCDDSEVANLCLEGIRCAVRIS 942

  Fly   911 AHYNLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYG 975
            ..:.:..:.||.|..|.:|:.|.:|....|....|.:|               ::|:..:.|..|
 Frog   943 CIFTMQLERDAYVQALARFSLLTASSSITEMKQKNIDT---------------IKTLITVAHTDG 992

  Fly   976 DCLRESWKHILDLYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEKPREKQESGLFSSLYSFISS 1040
            :.|..||..||....||           |:........|...|....||::     .|:.|:.|.
 Frog   993 NYLASSWHEILKCISQL-----------ELAQLIGTGVKTRYISGTGRERE-----GSIKSYTSG 1041

  Fly  1041 EGQREPTYEEQDFIKLGRKCIKECQLDQMLQESKFVQLESLQELLKCVLALLKAPQGHKSIGLPY 1105
                     .::|:.||.  :....:|:.       |:.|.||                |:|
 Frog  1042 ---------GEEFMSLGN--LVGVGVDKK-------QMTSFQE----------------SVG--- 1069

  Fly  1106 AEDQTVFWMEFLVKIVVHNRDRMIPLWPAVRDQMYLLLMGSASC-GY---DYLLNRCIVAVLKLA 1166
                     |...:.||...||              :..||... ||   |::  ||:.||
 Frog  1070 ---------ETSSQSVVVAVDR--------------IFTGSTRLDGYAIVDFV--RCLCAV---- 1105

  Fly  1167 IYLMRNEELCPIVLQSLKMLLMLKPALLLRISKQISIGIYELLKTSAQNIHSEQDWQII---FNL 1228
                           |:..|..:....:..:.|.:.|..|.:.:...|   ..:.||:|   ||.
 Frog  1106 ---------------SMDELASVHHPRMFSLQKIVEISYYNMNRIRLQ---WSRIWQVIGDHFNK 1152

  Fly  1229 LECVGAGAVPPNYDDA--------QLPLPPNGSAKSDGAISGEEDATAVPERGYTSDSE-ITKAS 1284
            :.|      .||.|.|        ||.:.         .:..:|.|....::.:....| |.|.:
 Frog  1153 VGC------NPNEDVAIFAVDSLRQLSMK---------FLEKDELANFRFQKDFLRPFEHIMKKN 1202

  Fly  1285 AAPAVSSPSAENWI------LVNNKDSEL-------------TTASRPQSPPSLSAPPVNTLVYN 1330
                 .||:..:.:      :||::...:             ..:....:...||...|...|.|
 Frog  1203 -----RSPTIRDMVIRCITQMVNSQAGNIRSGWKNVFAVFYQAASDHNGNIVELSFHTVGHTVTN 1262

  Fly  1331 CQLLDHAPFALFKCWDSLAFIVRSVAHITPYNFEACVRCIRIFVEACR----DGGIRQRRKLESA 1391
            . ...|.|.|:    ||               |:..::|:..|  ||.    |..:...|.:...
 Frog  1263 V-FQQHFPSAI----DS---------------FQDAIKCLSEF--ACNAAFPDTSMEAIRLIRYC 1305

  Fly  1392 AKQKSSKKRSERKPGMASSASSSNLTLLTGDPSDNQINGNAAEQEDLAQRYEQLSIQLLDLMYTL 1456
            ||..|.|.::.|:      .:|.::.:..||
 Frog  1306 AKYVSEKPQALRE------YTSDDMNVAPGD---------------------------------- 1330

  Fly  1457 YTRTAQIFRWWAEEGCTVPQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQRALLVHDL 1521
                                  .:|..||.|:|..::.:....:.:|||..::.:.:  ::....
 Frog  1331 ----------------------RVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFE--IMKSYG 1371

  Fly  1522 QTLSGTEWCSCFHQVLFPLLNEL-LPESNAAGQLDAALLEESRIRTAT------IMSKVFLQHLT 1579
            .|.....|...| :::|.:.:.: |||..:         |:|...|.|      .:..||.|..
 Frog  1372 HTFENHWWHDLF-RIVFRIFDNMKLPEQQS---------EKSEWMTTTCNHALYAICDVFTQFY- 1425

  Fly  1580 TLIELGNAFNELWL-DILDYIERFMKVGSDTLSEQMQEILKNMLLVMHSVRVFHNQDGSLQQALW 1643
                  .|.|.:.| |||..:...:|..::.|:......|:|::::         ........:|
 Frog  1426 ------EALNSVLLSDILSQLHWCVKQDNEQLARSGTNCLENLVIL---------NGEKFSPEVW 1475

  Fly  1644 E------------------LTWRRIGEFLPNLKEELFHDEGKR 1668
            :                  ||||      |...||   |..||
 Frog  1476 DKTCTCMLDIFKSTIPSVLLTWR------PTAMEE---DSDKR 1509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	190/795 (24%)
		Sec7_N	370..512	CDD:289549	35/153 (23%)
		Sec7	643..830	CDD:279680	69/188 (37%)
arfgef2	XP_002933226.3	PLN03076	6..1706	CDD:215560	379/1798 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010