DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and arfgef2

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_002666513.2	Gene:	arfgef2 / 100334572	ZFINID:	ZDB-GENE-090312-50	Length:	1846	Species:	Danio rerio

Alignment Length:	1832	Identity:	373/1832 - (20%)
Similarity:	656/1832 - (35%)	Gaps:	515/1832 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DLKHELNRIED-------LRQIEPQVFLAPFLEVIRTADATGPLTSLALASVNKLLSYGLIDPTS 104
            ::||||.:.:|       ...||...::.||  .:.....:..:.|.:|..:.||::||.|...:
Zfish    57 EIKHELEKQKDGTVVPPRANYIEADKYVLPF--ELACQSKSPRIVSTSLDCLQKLIAYGHITGNA 119

  Fly   105 PNLA----DIVERIADAVTHARFMGTDQSSDGVTFMRVIEVLHTLIRSP-----EGAAVSNVSMC 160
            |:.|    .:::|:.:.:.:. |.| .|:.:||. :::|:.|.|.:.||     ||..:..|.
Zfish   120 PDSAAPGKRLIDRLVETICNC-FQG-PQTDEGVQ-LQIIKALLTAVTSPHIEIHEGTILLTVR-- 179

  Fly   161 EVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMRLPQFA--------EERSDTMLQKRFTIG 217
                :|:.|....| :.:.:.:|:.:|..|:.:.|.|:...|        :||....|:....:.
Zfish   180 ----TCYNIYLASR-NLINQTTAKATLTQMLNVIFTRMENQAALEAQEAEKERQRLQLRNPSPVS 239

  Fly   218 DAASGATQEKLKRKTVAQAQTAPRKSSAVEEPPQTPQSANLTVPGHLKAPILATTPASPAGNILD 282
            ...|...|.  ..:|..:...:|....|..|...:|   .|:.||      :.:||::|..:
Zfish   240 SNPSPVNQN--PSQTPGRGSGSPWMGRACSEQNGSP---CLSPPG------VPSTPSTPQDS--- 290

  Fly   283 MQGKITQTP-----TTTASTGE-----------DETTVPETPVIQVESTESEPLLDGETG----- 326
              ..|...|     |...||.:           |:|||..:....||..|:.|..:.|.|
Zfish   291 --SSINSRPEEEFATDKQSTKDITHPDEELQESDQTTVDPSVTGGVEGEETHPQSETEAGSEVLE 353

  Fly   327 --EATSTLAEAN----------------------SSEYINS-VGVRFTQQSTD-------HDVTS 359
              |..|.|.:::                      .::.:|. |..|.::.|||       |...:
Zfish   354 ETEPDSGLGDSSVEGGLDQHSDSETRMPPPVVRVDTQQMNGMVDDRGSESSTDMLDAESIHGSQT 418

  Fly   360 LSPYGLPFIQELFRFLIILC----NPLDKQNSDSMMH------TGLSLLTVAFEVAADNIGKYEG 414
            .:.:.....::.|.....||    .||.....|...|      ..|.||....:.|......:|.
Zfish   419 AARFSHILQKDAFLVFRSLCKLSMKPLADGPPDPKSHELRSKVVSLQLLLSVLQGAGPVFRTHEM 483

  Fly   415 LLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEIIASDNPKT 479
            .:..:|..||..|.....|....:|...|.:...|....:.|||.|:|.:.|::...|. :...:
Zfish   484 FVNAIKQYLCVALSKNGVSSVPEVFELSLAIFLTLLSHFKVHLKMQIEVFFREIFLTIL-ETSSS 547

  Fly   480 PYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTLSATN--------AV 536
            .:|.:.:.:..|.::......|.::|:||||||...::||.|.|.|||.....:.        ..
Zfish   548 SFEHKWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGQELGMTPLQE 612

  Fly   537 YSTHIISMDTLLSVIDSI---ERNCAASKNSSNNRESLPEAAPATGGS---RHSRHNSGLEGIVI 595
            .|.....::.|:|::..:   .|:...:.|...|   |.:..||.|.|   :.|.|.|
Zfish   613 LSLRKKGLECLVSILKCMVEWSRDMYVNPNLQAN---LGQERPAEGDSADVKLSEHLS------- 667

  Fly   596 DSGNSVAAEEKVENIASFINASSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPEK 660
                  :..:.|.::.|.:::...:.:...        .||...:||:|.::..|.|.||::|::
Zfish   668 ------SRRDSVSSLDSTVSSGVQQSQPDH--------PEQYEVIKQQKEIIEHGIELFNKKPKR 718

  Fly   661 GIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVD 725
            |:|||||.|:|..  .|..:|.||::...||...:||::.:....:.:::..:||..||.|....
Zfish   719 GLQYLQEQGMLGT--SPEDIAQFLQQEERLDTTQVGEFLGENVKFNKEVMYCYVDRLDFCGKDFV 781

  Fly   726 QALRLYLETFRLPGEAPLIFLVLEHFSDHWHK--QNQDPFANVDAAFRLAYAIIMLNMDQHNSNA 788
            .|||.:||.|||||||..|..::|.|:..:.:  |.|..||:.|.|:.|||:||||..|.|:...
Zfish   782 SALRAFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQV 846

  Fly   789 KRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVM---------PAEQTGLVRENY 844
            |.   .||.|.:.|..||:|..:|..:|.|:.:::.|..::|.|         |......|....
Zfish   847 KN---KMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIAGKKIAMKESKEYSITPKSSKQNVANEK 908

  Fly   845 QWKVL--------------LRRGDTH-------DGHFHYVHDASYDVEIFNIVWGASLSALSF-M 887
            |.::|              |....:|       ..|..:|.      .:|.:.|...|:|.|. :
Zfish   909 QRRLLYNMEMEQMAKTAKALMEAVSHAQAPFFSATHLEHVR------PMFKLAWTPLLAAFSVGL 967

  Fly   888 FDKSTETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNETQQAV 952
            .|...:......|.|...:..|:..:|:..:.||.:..|.:||.|.:|....|....|.:|
Zfish   968 QDCDDQDVASLCLEGIRCAIRIACIFNMQLERDAYIQALARFTLLTASSSITEMKQKNIDT---- 1028

  Fly   953 NFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIEVEDFCEANGKAML 1017
                       ::|:.::.|..|:.|..||..||....||...:|:            ..|..|.
Zfish  1029 -----------IKTLIMVAHTDGNYLGNSWHEILRCISQLELAQLI------------GTGVKMR 1070

  Fly  1018 ILEKPREKQESGLFSSLYSFISSEGQREPTYEEQDFIKLGRKCIKECQLDQMLQESKFVQLESLQ 1082
            |....|: |..|:     ....|.|        ::|:.||        |..::......|:..:|
Zfish  1071 ISGVVRD-QGGGI-----KGFPSGG--------EEFMPLG--------LGTLVGGPDKRQMAHIQ 1113

  Fly  1083 ELLKCVLALLKAPQGHKSIGLPYAEDQTVFWMEFLVKIVVHNRDRMIPLWPAVRDQMYLLLMGSA 1147
            |                |:|            |...:.||...||:.
Zfish  1114 E----------------SVG------------ETSSQSVVVAVDRIF------------------ 1132

  Fly  1148 SCGYDYLLNRCIVAVLKLAIYLMRNEELCPIVLQSLKMLLMLKPALLLRISKQISIGIYELLKTS 1212
             .|...|....||..::.         ||.:   |:..|.......:..:.|.:.|..|.:.:..
Zfish  1133 -TGSTRLDGNAIVDFVRW---------LCAV---SMDELASAHQPRMFSLQKIVEISYYNMNRIR 1184

  Fly  1213 AQNIHSEQDWQII---FNLLECVGAGAVPPNYDDAQLPLPPNGSAKSDGAISGEEDATAVPERGY 1274
            .|   ..:.||:|   ||.:.|      .||.|.|...:.           |..:.:....|:|.
Zfish  1185 LQ---WSRIWQVIGDHFNKVGC------NPNEDVAIFAVD-----------SLRQLSMKFLEKGE 1229

  Fly  1275 TSDSEITKASAAPAVSSPSAENWILVNNKDSELTTASRPQSPPSLSAPPVNTLVYNC--QLLDHA 1337
            .::....|....|.       ..|:..|:                 :|.:..:|..|  |:::..
Zfish  1230 LANFRFQKDFLRPF-------EHIVKKNR-----------------SPTIRDMVIRCVAQMVNSQ 1270

  Fly  1338 PFALFKCWDS------------------LAFIVRSVAHITPY-----------NFEACVRCIRIF 1373
            ...:...|.:                  |||  ::..||...           :|:..|:|:..|
Zfish  1271 AANIRSGWKNIFSVFHQAASDHDENIVDLAF--QTTGHIVMNTFQQHFAAAIDSFQDAVKCLSEF 1333

  Fly  1374 V--EACRDGGIRQRRKLESAAKQKSSKKRSERKPGMASSASSSNLTLLTGDPSDNQINGNAAEQE 1436
            |  .|..|..:...|.:...||..|.:.::.|:      .:|.::.:..||
Zfish  1334 VCNAAFPDTSMEAIRLIRHCAKYVSERPQALRE------YTSDDMNVAPGD-------------- 1378

  Fly  1437 DLAQRYEQLSIQLLDLMYTLYTRTAQIFRWWAEEGCTVPQSAALWSPGWCPLLQGIARLAMDRRR 1501
                                                      .:|..||.|:|..::.:....:.
Zfish  1379 ------------------------------------------RVWVRGWFPILFELSCIINRCKL 1401

  Fly  1502 EVRTHAISCLQQRALLVHDLQTLSGT---EWCSCFHQVLFPLLNEL-LPESNAAGQLDAALLEES 1562
            :|||..::      ::...:::...|   .|.....:::|.:.:.: |||...         |::
Zfish  1402 DVRTRGLT------VMFEIMKSYGHTFEKHWWHDLFRIIFRIFDNMKLPEQQT---------EKT 1451

  Fly  1563 RIRTAT------IMSKVFLQHLTTLIELGNAFNELWLDILDYIERFMKVGSDTLSEQMQEILKNM 1621
            ...|.|      .:..||.|....|.|:      |..||...::..:|..::.|:......|:|:
Zfish  1452 EWMTTTCNHALYAICDVFTQFYEPLSEV------LLADIFAQLQWCVKQDNEQLARSGTNCLENL 1510

  Fly  1622 LLVMHSVRVFHNQDGSLQQALWE------------------LTWRRIGEFLPNLKEELFHDEGKR 1668
            :::         ........:|:                  ||||..|:     :||:  .|||.
Zfish  1511 VIL---------NGEKFSPEVWDVTCSCMLDIFQTTSPHALLTWRPAGQ-----EEEV--GEGKH 1559

  Fly  1669 AQTLTNPAPQAA 1680
            .....:...|::
Zfish  1560 MDVEVDSQSQSS 1571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	190/779 (24%)
		Sec7_N	370..512	CDD:289549	35/151 (23%)
		Sec7	643..830	CDD:279680	69/188 (37%)
arfgef2	XP_002666513.2	PLN03076	16..1760	CDD:215560	373/1832 (20%)
		DCB	38..213	CDD:292830	40/167 (24%)
		Sec7_N	426..580	CDD:289549	35/154 (23%)
		Sec7	701..885	CDD:279680	69/188 (37%)
		DUF1981	1223..1304	CDD:286414	14/106 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582824
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750