DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8841 and HID1

DIOPT Version :9

Sequence 1:	NP_610760.1	Gene:	CG8841 / 36336	FlyBaseID:	FBgn0033713	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_085133.1	Gene:	HID1 / 283987	HGNCID:	15736	Length:	788	Species:	Homo sapiens

Alignment Length:	854	Identity:	530/854 - (62%)
Similarity:	612/854 - (71%)	Gaps:	83/854 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNTDSKLNFRKAIVQLTQKNQKIDPSDEQFWEQFWQGHQTTLEDVFALVTSSEIRQIRNENPAN 65
            ||:||||||||||::|||.|.|.::.:|:.||:|||....|:::||||||.::|||.:|.|:|:|
Human     1 MGSTDSKLNFRKAVIQLTTKTQPVEATDDAFWDQFWADTATSVQDVFALVPAAEIRAVREESPSN 65

  Fly    66 LATLCYKAVEKLAQAVDSSCRTQAEQQCVLNCVRLLVRCLPYIFEDEKWRDFFWSSLP------- 123
            ||||||||||||.|..:|.|.::.|:|.||||.|||.|.|||||||..||.||||::|
Human    66 LATLCYKAVEKLVQGAESGCHSEKEKQIVLNCSRLLTRVLPYIFEDPDWRGFFWSTVPGAGRGGQ 130

  Fly   124 ---SQDKTMPLAQSLLNATCDLLFCPDFTVTATRRAGPEKAEELANIDSCEYIWEAGVGFAQSPP 185
               ..:...|||:|||.|..||||||||||.:.||:..:.||::.::||||||||||||||.||.
Human   131 GEEDDEHARPLAESLLLAIADLLFCPDFTVQSHRRSTVDSAEDVHSLDSCEYIWEAGVGFAHSPQ 195

  Fly   186 HNAHMERRRTELLKLLLTCFSEPMYRSP-QQSEEPNKWIAYFTSADNRHALPLFTSFLNTVCSYD 249
            .|...:..|.||||||||||||.||..| .:|...|.|:.:|.|.:||||||||||.|||||:||
Human   196 PNYIHDMNRMELLKLLLTCFSEAMYLPPAPESGSTNPWVQFFCSTENRHALPLFTSLLNTVCAYD 260

  Fly   250 PVGFGVPYNHLLFADTTEPLVEACLQLLIVTLDHDMVVQQQL----TQPGQASYDEGNCG-DNLF 309
            |||:|:|||||||:|..|||||...|:||||||||.......    |..|.|..|....| :|||
Human   261 PVGYGIPYNHLLFSDYREPLVEEAAQVLIVTLDHDSASSASPTVDGTTTGTAMDDADPPGPENLF 325

  Fly   310 INYLSRVHRDEDFHFVLKGITRLLNNPLVQNYLPNSTKRLHCHQELLILFWKICDYNKKFLYFVL 374
            :|||||:||:|||.|:||||.|||:|||:|.|||||||::..|||||:||||:||:|||||:|||
Human   326 VNYLSRIHREEDFQFILKGIARLLSNPLLQTYLPNSTKKIQFHQELLVLFWKLCDFNKKFLFFVL 390

  Fly   375 KSSDVLDILIPILYHLNYSRADQSRVGLMHIGVFILLLLSGERNFGVRLNKAYSATVPMDIPVFT 439
            |||||||||:|||:.||.:||||||||||||||||||||||||||||||||.||..|||||||||
Human   391 KSSDVLDILVPILFFLNDARADQSRVGLMHIGVFILLLLSGERNFGVRLNKPYSIRVPMDIPVFT 455

  Fly   440 GTHADLLITVFHKIIATGHQRLQPLFDCLLTILVNVSPYLKTLSMVASVKMLHLLEAFSTPWFLL 504
            ||||||||.||||||.:|||||||||||||||:||||||||:||||.:.|:|||||||||.|||.
Human   456 GTHADLLIVVFHKIITSGHQRLQPLFDCLLTIVVNVSPYLKSLSMVTANKLLHLLEAFSTTWFLF 520

  Fly   505 SAPSNHHLVFFLLEIFNNIIQYQFDGNSNLVYTIIRKRHVFHAMANLPTDMAGIAKCLSGRKTGG 569
            ||..||||||||||:|||||||||||||||||.|||||.:||.:||||||...|.|.|..|
Human   521 SAAQNHHLVFFLLEVFNNIIQYQFDGNSNLVYAIIRKRSIFHQLANLPTDPPTIHKALQRR---- 581

  Fly   570 KFNLPRVPQRRTPAVSQELPSAHVPEEYNEEDEDEDEEEIINEEPKAEEDLESETESHERSQAGE 634
                     ||||                                        |..|...||.|.
Human   582 ---------RRTP----------------------------------------EPLSRTGSQEGT 597

  Fly   635 LQSDVLTAQPAEPGTLKTSLLDTPGITQMTEREQAHPNDKPQVEDSTDIVPYDRSAASTPTDERK 699
            .......|.|||||||||||:.||||.::||:.|..       ||.|     .||....|....:
Human   598 SMEGSRPAAPAEPGTLKTSLVATPGIDKLTEKSQVS-------EDGT-----LRSLEPEPQQSLE 650

  Fly   700 STSPTELSRLSVAHRASIR-MVPGESDRWTPTPEWIVSWRSKLPLQTIMRLLQVLVPQVEKICID 763
            ..||.: ...|.|.|...| .....|.:|:|||||::||:|||||||||||||||||||||||||
Human   651 DGSPAK-GEPSQAWREQRRPSTSSASGQWSPTPEWVLSWKSKLPLQTIMRLLQVLVPQVEKICID 714

  Fly   764 KGLTDESEILKFLQHGTLVGLLPVPHPILIRKYQANAGTTAWFRTYIWGVIYLRNVEPAIWYDTE 828
            ||||||||||:|||||||||||||||||||||||||:||..|||||:|||||||||:|.:||||:
Human   715 KGLTDESEILRFLQHGTLVGLLPVPHPILIRKYQANSGTAMWFRTYMWGVIYLRNVDPPVWYDTD 779

  Fly   829 VKLFEIQRV 837
            |||||||||
Human   780 VKLFEIQRV 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8841	NP_610760.1	Hid1	1..834	CDD:289492	525/849 (62%)
HID1	NP_085133.1	Hid1	1..785	CDD:315405	525/849 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..316		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..681		46/175 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140628
Domainoid	1	1.000	1005	1.000	Domainoid score	I29
eggNOG	1	0.900	-	-		E1_KOG2226
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12737
Inparanoid	1	1.050	1014	1.000	Inparanoid score	I283
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55846
OrthoDB	1	1.010	-	-		D163246at33208
OrthoFinder	1	1.000	-	-		FOG0003901
OrthoInspector	1	1.000	-	-		oto91615
orthoMCL	1	0.900	-	-		OOG6_103153
Panther	1	1.100	-	-	LDO	PTHR21575
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1791
SonicParanoid	1	1.000	-	-		X4300
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800