DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8841 and SPAP27G11.12

DIOPT Version :9

Sequence 1:	NP_610760.1	Gene:	CG8841 / 36336	FlyBaseID:	FBgn0033713	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_593417.1	Gene:	SPAP27G11.12 / 2541539	PomBaseID:	SPAP27G11.12	Length:	797	Species:	Schizosaccharomyces pombe

Alignment Length:	895	Identity:	220/895 - (24%)
Similarity:	372/895 - (41%)	Gaps:	162/895 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNTDSKLNFRKAIVQLTQKNQKIDPSDEQFWEQFWQGHQTTLEDVFALVTSSEIRQIRNENPAN 65
            ||:..|||:||.|:::|.:  ::..|..:..||:.|...:|| ||||.|::..::.::::..|.|
pombe     1 MGSQQSKLDFRNAVLRLHE--ERNIPKFDLIWERLWTLPETT-EDVFHLMSIDDLTKVKDNAPEN 62

  Fly    66 LATLCYKAVEKLAQAV------DSSCRTQAEQQCVLNCVRLLVRCLPYIFEDE---KWRDFF-WS 120
            |.|:.....:||....      |.:..|   .:|.|||:|||.|.:|.||||:   :|.|:| |:
pombe    63 LQTIIAVLWDKLEDLQKETLFDDPAAPT---TKCALNCMRLLTRLMPIIFEDKSMLEWFDYFAWT 124

  Fly   121 SLPSQDKTMPLAQSLLNATCDLLFCPDFTVTATRRAGPEKAEELANIDSCEYIWEAGVGFAQSPP 185
            .....:...|...|.||...|.||..:||:       |...:....:..|  |||.||.:..:..
pombe   125 VPKDPNINTPRGASFLNTVVDYLFLINFTI-------PAHNDLTHGVHYC--IWETGVVYHPTML 180

  Fly   186 HNAHMERRRTELLKLLLTCFSEPMYRSPQQSEEPNKWIAYFTSADNRH-ALPLFTSFLNTVCSYD 249
            .....|..|.|:|:|||:.|||.:||:....   :...||..|..||. .|.|.:|.:||...::
pombe   181 KERSYELHRVEVLRLLLSLFSEEIYRTDGNG---SSCCAYVASIANRRLVLCLLSSLINTAMRFN 242

  Fly   250 PVGFGVPYNHLLFADTTEPLVEACLQLLIVTLDHDMVVQQQLTQPGQASYDEGNCGDNLFINY-- 312
            .:.:...:..|..:.....|:|.|..:|::.:.                 :|.|.|...:.||
pombe   243 TMFWKPEFLPLDNSVAHMSLIEYCFSVLLILMS-----------------EENNNGTPCYNNYRS 290

  Fly   313 -------------LSRVHRDEDFHFVLKGITRLLNNPLVQNYLPNSTKRLHCHQELLILFWKI-C 363
                         ||::....||..:|.|::|||..|:.......|:..:..:..|:::|.|: .
pombe   291 SKNTLPKNYFSILLSKLQPYSDFQIILDGMSRLLYPPMQSTIPKRSSLIMFDYYPLVLIFCKLFI 355

  Fly   364 DYNKKFLYFVLKSSDVLDILIPILYHLNYSRADQSRVGLMHIGVFILLLLSGERNFGVRLNKAY- 427
            .||::|.::::.:...:|:.|.:||.......|.|....:.:.|.:|..|:.|:.|..||||.:
pombe   356 HYNERFFHYLIDTDRAIDLFIFLLYLSFEYLGDPSTYNHLKLCVILLKRLTAEKYFCKRLNKPFQ 420

  Fly   428 ---SATVPMDIPVFTGTHADLLITVFHKII---ATGHQRLQPLFDCLLTILVNVSPYLKTLSMVA 486
               :..:.|.:|...||:||..|.....::   ...|..:..:..|.|..|   ..|.:.|:..:
pombe   421 QQTALPISMPVPFEGGTYADFTIIAISLLVQYTKDYHSEIAQMLCCSLCYL---CLYAQNLNSHS 482

  Fly   487 SVKMLHLLEAFSTPWFLLSAPSNHHLVFFLLEIFNNIIQYQFDGNSNLVYTIIRKRHVFHAMANL 551
            |..:..|.::.|.|.||:|...||.::.:::...||.|||....|:.|:|.....:....|::.|
pombe   483 SQSLFELFQSASYPGFLISNDVNHKILKYVIGAINNAIQYAQKYNAPLLYFFSMHKDYIEAVSAL 547

  Fly   552 PTDMAGIAKCLSGR-------KTGGKFN---LPRVPQRRTPAVSQELPSAHVPEEYNE-----ED 601
            ..|.....:..|..       :.|..|:   ...:...|...|..:.|:.:.|.|.:|     ..
pombe   548 SFDAIMSVRNSSAEGDSAYWTRNGKTFSSKAFDSILLSRLRYVRSKSPTPYYPIESSEFGFTNLK 612

  Fly   602 EDEDEEEIINEEPKAEEDLESET-ESHERSQAGELQSDVLTAQPAEPGTLKTSLLDTPGITQ-MT 664
            :...::||.:...||   |.|.: .:|..|            :|.:|     .|...|.:.: :|
pombe   613 DVTSKDEITDGFDKA---LRSNSLRTHRDS------------RPVQP-----LLKQRPQLHRALT 657

  Fly   665 EREQAHPNDKPQVEDSTDIVPYDRSAASTPTDERKSTSPTELSRLSVAHRASIRMVPGESDRWTP 729
            |....|.||: .:||               |||.| ..|       :||....        .:.|
pombe   658 ESATLHGNDR-SLED---------------TDEAK-VEP-------IAHSVDY--------TFKP 690

  Fly   730 TPEWIVSWRSKLPLQTIMRLLQVLVPQVEKICIDKGLTDESEILKFLQHGTLVGLLPVPHPILIR 794
            |.||...|...|..:|::.:...|..::..  :.|.....|||:..::    ....|..:...|.
pombe   691 TVEWWNKWWPSLNFRTMLDIFTDLSLKISD--MKKAGHPASEIMAMIK----TQKYPATNQPYIP 749

  Fly   795 KYQANAGTTAW-------FRTYIWGVI----YLRNVEPAIWYDTEVKLFE 833
            ||:    |..|       .|.:.|.|.    ..:...|.|:..|:||:|:
pombe   750 KYR----TKEWRQQLANFARLFAWQVSCDLDSHKREGPGIFEGTDVKIFD 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8841	NP_610760.1	Hid1	1..834	CDD:289492	220/895 (25%)
SPAP27G11.12	NP_593417.1	Hid1	1..795	CDD:289492	219/893 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	197	1.000	Domainoid score	I680
eggNOG	1	0.900	-	-		E1_KOG2226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	197	1.000	Inparanoid score	I1015
OMA	1	1.010	-	-		QHG55846
OrthoFinder	1	1.000	-	-		FOG0003901
OrthoInspector	1	1.000	-	-		oto102065
orthoMCL	1	0.900	-	-		OOG6_103153
Panther	1	1.100	-	-	O	PTHR21575
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1791
SonicParanoid	1	1.000	-	-		X4300
TreeFam	1	0.960	-	-
	12	11.860