DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8841 and Hid1

DIOPT Version :9

Sequence 1:	NP_610760.1	Gene:	CG8841 / 36336	FlyBaseID:	FBgn0033713	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_780663.1	Gene:	Hid1 / 217310	MGIID:	2445087	Length:	788	Species:	Mus musculus

Alignment Length:	860	Identity:	533/860 - (61%)
Similarity:	613/860 - (71%)	Gaps:	95/860 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNTDSKLNFRKAIVQLTQKNQKIDPSDEQFWEQFWQGHQTTLEDVFALVTSSEIRQIRNENPAN 65
            ||:.|||||||||::|||.|.|.::.:|..||:|||....|:::||||||.::|||.:|.|:|:|
Mouse     1 MGSADSKLNFRKAVIQLTTKTQPVEATDNAFWDQFWADTATSVQDVFALVPAAEIRAVREESPSN 65

  Fly    66 LATLCYKAVEKLAQAVDSSCRTQAEQQCVLNCVRLLVRCLPYIFEDEKWRDFFWSSLP------- 123
            ||||||||||||.|..:..|.::.|:|.||||.|||.|.|||||||..||.||||::|
Mouse    66 LATLCYKAVEKLVQGAEGGCHSEKEKQVVLNCSRLLTRVLPYIFEDPDWRGFFWSTVPGAGRGGQ 130

  Fly   124 ---SQDKTMPLAQSLLNATCDLLFCPDFTVTATRRAGPEKAEELANIDSCEYIWEAGVGFAQSPP 185
               ..:...|||:|||.|..||||||||||...||...:.||::.::||||||||||||||.||.
Mouse   131 GEEEDENARPLAESLLLAIADLLFCPDFTVQNHRRNDVDSAEDVHSLDSCEYIWEAGVGFAHSPQ 195

  Fly   186 HNAHMERRRTELLKLLLTCFSEPMYRSPQ-QSEEPNKWIAYFTSADNRHALPLFTSFLNTVCSYD 249
            .|...:..|.||||||||||||.||..|. :|...|.|:.:|.|.:||||||||||.|||||:||
Mouse   196 PNYIHDMNRMELLKLLLTCFSEAMYLPPSPESGSTNPWVQFFCSTENRHALPLFTSLLNTVCAYD 260

  Fly   250 PVGFGVPYNHLLFADTTEPLVEACLQLLIVTLDHDMVVQQQLTQP-------GQASYDEGNCG-D 306
            |||:|:|||||||:|..|||||...|:||||||||....   |.|       |.|..|....| :
Mouse   261 PVGYGIPYNHLLFSDYREPLVEEAAQVLIVTLDHDSATS---TSPTVDGTTTGTAMDDADPPGPE 322

  Fly   307 NLFINYLSRVHRDEDFHFVLKGITRLLNNPLVQNYLPNSTKRLHCHQELLILFWKICDYNKKFLY 371
            |||:|||||:||:|||.|:||||.|||:|||:|.|||||||::..|||||:||||:||:|||||:
Mouse   323 NLFVNYLSRIHREEDFQFILKGIARLLSNPLLQTYLPNSTKKIQFHQELLVLFWKLCDFNKKFLF 387

  Fly   372 FVLKSSDVLDILIPILYHLNYSRADQSRVGLMHIGVFILLLLSGERNFGVRLNKAYSATVPMDIP 436
            ||||||||||||:||||.||.:||||||||||||||||||||||||||||||||.||..||||||
Mouse   388 FVLKSSDVLDILVPILYFLNDARADQSRVGLMHIGVFILLLLSGERNFGVRLNKPYSVRVPMDIP 452

  Fly   437 VFTGTHADLLITVFHKIIATGHQRLQPLFDCLLTILVNVSPYLKTLSMVASVKMLHLLEAFSTPW 501
            |||||||||||.||||||.:|||||||||||||||:||||||||:||||.:.|:|||||||||.|
Mouse   453 VFTGTHADLLIVVFHKIITSGHQRLQPLFDCLLTIVVNVSPYLKSLSMVTANKLLHLLEAFSTTW 517

  Fly   502 FLLSAPSNHHLVFFLLEIFNNIIQYQFDGNSNLVYTIIRKRHVFHAMANLPTDMAGIAKCLSGRK 566
            ||.||..||||||||||:|||||||||||||||||.|||||.|||.:||||||...|.|.|..|
Mouse   518 FLFSASQNHHLVFFLLEVFNNIIQYQFDGNSNLVYAIIRKRAVFHQLANLPTDPPSIHKALQRR- 581

  Fly   567 TGGKFNLPRVPQRRTPAVSQELPSAHVPEEYNEEDEDEDEEEIINEEPKAEEDLESETESHERSQ 631
                        ||||                                        |..|...||
Mouse   582 ------------RRTP----------------------------------------EPLSRTGSQ 594

  Fly   632 AGELQSDVLTAQPAEPGTLKTSLLDTPGITQMTEREQAHPNDKPQVEDST--DIVPYDR--SAAS 692
            .|........|.|||||||||||:.||||.::||:.|..       ||.|  .:.|..:  ||.:
Mouse   595 EGTSMEGSRPAAPAEPGTLKTSLVATPGIDKLTEKSQVS-------EDGTLRSLEPESQQSSAEN 652

  Fly   693 TPTDERKSTSPTELSRLSVAHRASIRMVPGESDRWTPTPEWIVSWRSKLPLQTIMRLLQVLVPQV 757
            :|:|...|.:..|..|||.|         ..|.:|:||.:||:||:|||||||||||||||||||
Mouse   653 SPSDGESSQTWREQRRLSNA---------SASGQWSPTSDWILSWKSKLPLQTIMRLLQVLVPQV 708

  Fly   758 EKICIDKGLTDESEILKFLQHGTLVGLLPVPHPILIRKYQANAGTTAWFRTYIWGVIYLRNVEPA 822
            ||||||||||||||||:|||||||||||||||||||||||||:||..|||||:|||||||||:|.
Mouse   709 EKICIDKGLTDESEILRFLQHGTLVGLLPVPHPILIRKYQANSGTAMWFRTYMWGVIYLRNVDPP 773

  Fly   823 IWYDTEVKLFEIQRV 837
            |||||:|||||||||
Mouse   774 IWYDTDVKLFEIQRV 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8841	NP_610760.1	Hid1	1..834	CDD:289492	528/855 (62%)
Hid1	NP_780663.1	Hid1	1..785	CDD:289492	528/855 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..316		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..680		48/177 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830599
Domainoid	1	1.000	1005	1.000	Domainoid score	I28
eggNOG	1	0.900	-	-		E1_KOG2226
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12737
Inparanoid	1	1.050	1016	1.000	Inparanoid score	I283
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55846
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003901
OrthoInspector	1	1.000	-	-		oto95197
orthoMCL	1	0.900	-	-		OOG6_103153
Panther	1	1.100	-	-	LDO	PTHR21575
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1791
SonicParanoid	1	1.000	-	-		X4300
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790