DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30046 and spon1b

DIOPT Version :9

Sequence 1:	NP_001286341.1	Gene:	CG30046 / 36334	FlyBaseID:	FBgn0050046	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	XP_005174403.1	Gene:	spon1b / 58029	ZFINID:	ZDB-GENE-000427-10	Length:	804	Species:	Danio rerio

Alignment Length:	838	Identity:	236/838 - (28%)
Similarity:	351/838 - (41%)	Gaps:	214/838 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FMISVSGNPETYILGQEYNVSLNAFNGHRYISF-IMALENENGDFSYNDDLGRFELSDLIETRFS 109
            |.:.|.|.||||..|..|.|||.|.:...:..| ::||:......|.:|..|.|:|.|..:|:|.
Zfish    58 FRLKVEGEPETYQPGSTYRVSLYASSPSYFRGFTLIALKEGREGVSPDDYAGTFKLIDESDTQFM 122

  Fly   110 PNCINMVENTNTNSKTHMHLTWVAPSEPGSGCVLIRATVQQHREVWHMDDGGLTKRICEEVTDDV 174
            .||...|..:....:|.:.:.|.||.. |||||.::|:|.|.|.::..|:|.||||:||:....:
Zfish   123 TNCPPAVTESIPRRRTRIQVFWTAPPS-GSGCVTLKASVVQRRIIFFQDEGSLTKRLCEKDPVAI 186

  Fly   175 ESQPTAPAAVDVPCCACDEARYELIFEGVWSRNLHPKDFPTRG--WETRFCELLGAAHSSDYRFW 237
            ..:|..      .||||..|:|.:.|.|.||..|||||:|.|.  |..    |:||:|:..|..|
Zfish   187 TEKPAQ------ECCACGTAKYRVTFYGNWSEKLHPKDYPRRANHWSA----LIGASHTRSYVLW 241

  Fly   238 ESGELASVAMKEYAEHCSSRLLEREFSINFRDQKIRTII--KARGPSYP--NISSKTMASVRVDP 298
            |.|..||..:|:.:|:.|...:|.|  |..:...:.|:|  ||:.|::.  ||.:...|...||.
Zfish   242 EYGGFASEGVKQVSEYGSPVKMEEE--IRQKGDDVMTVIKTKAQWPAWQPLNIRAAPSAEFSVDR 304

  Fly   299 IHHMVSFASKIEPSPDWIVGVTGLELCLRNCTWMEEKVINLYPWDVGTDSGPTYTSSDQPQVPPD 363
            :.|::||.:.:.|||||.||::|.:||.|:|.|:::.|.:|.|||.|||||.:|.|.::|.:|.:
Zfish   305 VRHLMSFLTMLGPSPDWNVGLSGEDLCTRDCGWVQKLVKDLVPWDAGTDSGVSYESPNKPSIPQE 369

  Fly   364 VIRRMRSDFPNDPRSPFYDISGTPMKPMAILTVKRQRIYERRC--------------ADEDSNND 414
            .||.:.|  .:.|:|||||.||.||.|:..:.|:|......:|              |.|:....
Zfish   370 RIRPLTS--LDHPQSPFYDPSGGPMTPLGRVVVERIARKGEQCNTVPDTIDDIVADIAQEEKEEG 432

  Fly   415 PDVPRECFTHPWSSWSDCSSK-CGVGMQYRRRVYK---QPELARVYNCNEAQYEERECQGEMCGQ 475
            .:.|..|....||.||.|||. |..|.:.|:|:.|   .|.|.    |...| :...|.|..|
Zfish   433 DNTPETCIYSNWSPWSACSSSTCDKGRRMRQRMLKAQLDPNLP----CLHTQ-DFEPCMGPGC-- 490

  Fly   476 NNLMREPEEFEDLEPDPRRIGYQPSQQRRAECELSSWGSWSPCSVTCGDGYEMRQRQYLN--PQA 538
                                    |::..:.|.:|.|.||||||.:||.|...|:| |:.  |:.
Zfish   491 ------------------------SEEEASTCMMSEWISWSPCSASCGMGMRSRER-YVKQFPED 530

  Fly   539 EFDCQGVHRMELQETRKC-SGRDCLGSLPGSYSTDMDSPYGGASPGRIGGNMYGPQLEPEAENFG 602
            ...|    .:..:||.|| ...||                   ||.......:| :.||.:.:.|
Zfish   531 GSSC----TLPTEETEKCVVNDDC-------------------SPSSCVVTEWG-EWEPCSVSCG 571

  Fly   603 DYDDSRNGAVGGFEVGNLKGNIGNWALNRQTNLGRDVPSLRPTNYDRARQQAEKSERTTWSGQSR 667
                                            ||.           |.|::..|.:.:..|
Zfish   572 --------------------------------LGM-----------RRRERMMKMDASDGS---- 589

  Fly   668 PDDPRLEDVERAPWHRQRPSNKYGSIVEAPEMVSPREPWQRANNFGNPDMYTPGGDVDPSLSYRC 732
            |...::.:.|:.            .:.|...:|....||   :::|             ..|..|
Zfish   590 PCRVQMAEAEKC------------MMPECNAVVCMLSPW---SDWG-------------ECSVSC 626

  Fly   733 FQMVQTAQPRCHDQTITGHFWFYNFCADE------CMLYAADQC--DRNVNKFRRWEDCEKCRQP 789
            ...::|.|.........|.      |.||      |||   .:|  |..::::..|.:|.|....
Zfish   627 GVGMRTRQRMLKTPVKPGQ------CPDELEQVEKCML---PECPTDCMLSEWSAWSECNKSCGK 682

  Fly   790 G------MAALQQEHTNSP-------------QCEDFRAIWQAEQRAREEKRPSNRRR 828
            |      |..|:.:....|             :|.  |....:|:|.|:|  .|:|||
Zfish   683 GHMIRSRMVKLEPQFGGLPCPETVQRKKCKIRKCS--RGSRASEKRKRQE--VSDRRR 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30046	NP_001286341.1	Reeler	28..167	CDD:260081	46/121 (38%)
		Spond_N	194..382	CDD:283999	77/193 (40%)
		TSP1	425..473	CDD:214559	18/51 (35%)
		TSP1	510..561	CDD:214559	20/53 (38%)
spon1b	XP_005174403.1	Reeler	50..179	CDD:260081	46/121 (38%)
		Spond_N	200..387	CDD:283999	78/194 (40%)
		TSP_1	442..490	CDD:278517	18/52 (35%)
		TSP_1	501..546	CDD:278517	20/49 (41%)
		TSP_1	558..606	CDD:278517	12/107 (11%)
		TSP_1	614..661	CDD:278517	14/71 (20%)
		TSP_1	668..716	CDD:278517	7/47 (15%)
		TSP1	756..804	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574082
Domainoid	1	1.000	186	1.000	Domainoid score	I3283
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2015
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104958
Panther	1	1.100	-	-	O	PTHR11311
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2543
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.850