DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30046 and Spon1

DIOPT Version :9

Sequence 1:	NP_001286341.1	Gene:	CG30046 / 36334	FlyBaseID:	FBgn0050046	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_663559.1	Gene:	Spon1 / 233744	MGIID:	2385287	Length:	807	Species:	Mus musculus

Alignment Length:	890	Identity:	232/890 - (26%)
Similarity:	363/890 - (40%)	Gaps:	228/890 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PLVELLLLGSLVIGRV--SSLICTRRPANTGSPKSPVDENFMISVSGNPETYILGQEYNVSLNA- 69
            ||...|......:.:|  |...|:|.....|:.:....| |.:.|.|:|:.|..|..|.|:|:|
Mouse    22 PLAAALAFSDETLDKVTKSEGYCSRILRAQGTRREGYTE-FSLRVEGDPDFYKPGSSYRVTLSAA 85

  Fly    70 ----FNGHRYISFIMALENENGDFSYNDDLGRFELSDLIETRFSPNCINMVENTNTNSKTHMHLT 130
                |.|   .:.|...||:.|| ...|..|.|::.|..||:|..||...|..:....:|.:.:.
Mouse    86 PPSYFRG---FTLIALKENQEGD-KEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVF 146

  Fly   131 WVAPSEPGSGCVLIRATVQQHREVWHMDDGGLTKRICEEVTDDVESQPTAPAAVDVP---CCACD 192
            |:|| ..|:|||:::|::.|.|.::..|:|.|||::||:       .||.....|.|   ||||.
Mouse   147 WIAP-PTGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQ-------DPTLDGVTDRPILDCCACG 203

  Fly   193 EARYELIFEGVWSRNLHPKDFPTRG--WETRFCELLGAAHSSDYRFWESGELASVAMKEYAEHCS 255
            .|:|.|.|.|.||...||||:|.|.  |..    ::|.:||.:|..||.|..||..:|:.||..|
Mouse   204 TAKYRLTFYGNWSEKTHPKDYPRRANHWSA----IIGGSHSKNYVLWEYGGYASEGVKQVAELGS 264

  Fly   256 SRLLEREFSINFRDQKIRTIIKARG--PSYP--NISSKTMASVRVDPIHHMVSFASKIEPSPDWI 316
            ...:|.|  |..:..::.|:|||:.  |::.  |:.:...|...||...|::||.:.:.|||||.
Mouse   265 PVKMEEE--IRQQSDEVLTVIKAKAQWPAWQPVNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWN 327

  Fly   317 VGVTGLELCLRNCTWMEEKVINLYPWDVGTDSGPTYTSSDQPQVPPDVIRRMRSDFPNDPRSPFY 381
            ||::..:||.:.|.|:::.|.:|.|||.|||||.||.|.::|.:|.:.||.:.|  .:.|:||||
Mouse   328 VGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTS--LDHPQSPFY 390

  Fly   382 DISGTPMKPMAILTVKRQRIYERRC--------------ADEDSNNDPDVPRECFTHPWSSWSDC 432
            |..|..:..:|.:.::|......:|              |.|:.:.| |.|..|....||.||.|
Mouse   391 DPEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDED-DTPETCIYSNWSPWSAC 454

  Fly   433 SSK-CGVGMQYRRRVYKQPELARVYNCNEAQYEERECQGEMCGQNNLMREPEEFEDLEPDPRRIG 496
            ||. |..|.:.|:|:.| .:|.....|.:.| :.:.|.|..|
Mouse   455 SSSTCEKGKRMRQRMLK-AQLDLSVPCPDTQ-DFQPCMGPGC----------------------- 494

  Fly   497 YQPSQQRRAECELSSWGSWSPCSVTCGDGYEMRQRQYLNPQAEFDCQG-VHRMELQETRK----- 555
               |.:..:.|.:|.|.:||||||:||.|...|:| |:.   :|...| |..:..:||.|
Mouse   495 ---SDEDGSTCTMSEWITWSPCSVSCGMGMRSRER-YVK---QFPEDGSVCMLPTEETEKCTVNE 552

  Fly   556 -CSGRDCLGSLPGSYSTDMDSPYGGASPGRIGGNMYGPQLEPEAENFGDYDDSRNGAVGGFEVGN 619
             ||...||                                   ...:|::||.  .|..|
Mouse   553 ECSPSSCL-----------------------------------VTEWGEWDDC--SATCG----- 575

  Fly   620 LKGNIGNWALNRQTNLGRDVPSLRPTNYDRARQQAEKSERTTWSGQSRPDDPRLEDVERAPWHRQ 684
                :|....:|...:.       |.:....:.:..::|:...        |....:
Mouse   576 ----MGMKKRHRMVKMS-------PADGSMCKAETSQAEKCMM--------PECHTI-------- 613

  Fly   685 RPSNKYGSIVEAPEMVSPREPWQRANNFGNPDMYTPGGDVDPSLSYRCFQMVQTAQPRCHDQTIT 749
                        |.::||...|.                   ..|..|.:.::|.|.........
Mouse   614 ------------PCLLSPWSEWS-------------------DCSVTCGKGMRTRQRMLKSLAEL 647

  Fly   750 GHFWFYNFC------ADECMLYAADQC--DRNVNKFRRWEDCEK-CRQ----------------- 788
            |.      |      |::|||   .:|  |..::::.:|.:|.| |.:
Mouse   648 GD------CNEDLEQAEKCML---PECPIDCELSEWSQWSECNKSCGKGHMIRTRTIQMEPQFGG 703

  Fly   789 -PGMAALQQEHTNSPQCEDFRAIWQAEQRAREEKRPSNRRRNYGD 832
             |....:|::...:.:|....::.:...|...|.|.|.:.|...|
Mouse   704 VPCPETVQRKKCRTRKCLRSPSVQKLRWREARESRRSEQLREESD 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30046	NP_001286341.1	Reeler	28..167	CDD:260081	47/143 (33%)
		Spond_N	194..382	CDD:283999	75/193 (39%)
		TSP1	425..473	CDD:214559	17/48 (35%)
		TSP1	510..561	CDD:214559	22/57 (39%)
Spon1	NP_663559.1	Reeler	43..182	CDD:260081	47/144 (33%)
		Spond_N	205..392	CDD:283999	76/194 (39%)
		TSP_1	446..494	CDD:278517	17/49 (35%)
		TSP_1	505..554	CDD:278517	20/52 (38%)
		TSP_1	562..610	CDD:278517	10/73 (14%)
		TSP_1	618..665	CDD:278517	13/74 (18%)
		TSP_1	672..720	CDD:278517	6/47 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..752		6/17 (35%)
		TSP_1	758..807	CDD:278517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831119
Domainoid	1	1.000	184	1.000	Domainoid score	I3399
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1946
Isobase	1	0.950	-	0	Normalized mean entropy	S5564
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104958
Panther	1	1.100	-	-	O	PTHR11311
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2543
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.800