Protein Alignment CG30046 and spon-1

DIOPT Version :10

• Sequence 1: NP_725129.1
• Gene: CG30046 / 36334
• FlyBaseID: FBgn0050046
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_495473.2
• Gene: spon-1 / 174169
• WormBaseID: WBGene00006893
• Length: 819
• Species: Caenorhabditis elegans
• Alignment Length: 830
• Identity: 219/830 - (26%)
• Similarity: 351/830 - (42%)
• Gaps: 175/830 - (21%)

  Fly     9 LVELLLLGSLVIG-RVSSLICTRRPANTGSPKSPVDENFMISVSGN-------PETYILGQEYNV 65
            :::.:||..|:.. ......||.:|......|||....::|.::|.       .:.::.|:.|.|
 Worm     7 ILQFILLLLLIFSCNADEAKCTIKPYEAKGDKSPGSNGYVIEINGTTTKSMDISKGFVPGEIYKV 71

  Fly    66 SLNA----FNGHRYISFIMALENENGDFSYNDDLGRFE-LSDLIETRFSPNCINM-VENTNTNSK 124
            |:..    :....:..|::     :..|..|...|.:: :....:.|.||.|... |.:.|..||
 Worm    72 SIRGWRTQYTVKTFRGFVV-----SSLFEDNTSAGSWQVVKGHGDARISPGCRQSGVSHANLKSK 131

  Fly   125 THMHLTWVAPSEPGSGCVLIRATVQQHREVWHMDDGGLTKRICEEVTDDVESQPTAPAAVDVPCC 189
            |.:|:.|.|| |..||||:.||:|.:.:.:|..:..|||.::|.:....:......|:|.   ||
 Worm   132 TSVHMMWKAP-EVSSGCVVFRASVIETKYIWFTEAEGLTVKLCIQKGTQILKPVDDPSAT---CC 192

  Fly   190 ACDEARYELIFEGVWSRNLHPKDFPTRGWETRFCELLGAAHSSDYRFWESGELASVAMKEYAEHC 254
            |||.|:|:|.|.|:||:|.||||:||....|.|.::||::|||:|..|..|.:::..|||.||..
 Worm   193 ACDIAQYDLEFTGIWSKNTHPKDYPTLEHLTHFTDMLGSSHSSNYSLWTIGGISTDGMKEIAEWG 257

  Fly   255 SSRLLEREFSINFRDQKIRTIIKARGPSYPNISSKTMASVRVDPIHHMVSFASKIEPSPDWIVGV 319
            ::...|.|  ...:..::|:::|.:|..:|::...|.:...|:..||.||.|:...|||||.||:
 Worm   258 NTYKAEAE--AKAKASEVRSLMKVKGLWFPDVQGTTKSQFVVNKYHHFVSLATMFGPSPDWCVGL 320

  Fly   320 TGLELCLRNCTWMEEKVINLYPWDVGTDSGPTYTSSDQPQVPPDVIRRMRSDFPNDPRSPFYDIS 384
            :.:.|||.:|||.||:...|.|:|.||||||||.|.::|..|.:.|..:.:..  :|.||||:..
 Worm   321 SSVNLCLPDCTWAEERTFELQPFDAGTDSGPTYMSPNEPTEPREPIHWITTKL--NPLSPFYNSK 383

  Fly   385 GTPMKPMAILTVKRQRIYERRCADED---------SNNDPDVP----RECFTHPWSSWSDCSSKC 436
            ...:..:|.:.::|:.:....|..:|         :|...|..    |||....|..||.||:.|
 Worm   384 SDTIPTLAKVILRRKNVTSSECKSDDILKAEAHNITNTSEDEEYKDRRECMMTQWEPWSLCSATC 448

  Fly   437 GVGMQYRRRVYKQPELARVYNCNEAQYEERECQGEMCGQNNLMREPEEFEDLEPDPRRIGYQPSQ 501
            |.|::.|.|||..|..|:|::|:....|::.|..::    |.....|.|.
 Worm   449 GKGIRIRSRVYVFPIKAQVFHCHRQTTEKQFCNAKI----NECENSEAFS--------------- 494

  Fly   502 QRRAECELSSWGSWSPCSVTCGDGYEMRQRQYLNPQAEF-DCQGVHRMELQETRKC---SGRDCL 562
               ::|::||||||..|||.||.|...|.|.:|||..:. ||.    ::|:....|   :|.||
 Worm   495 ---SKCQVSSWGSWGECSVQCGHGMRSRNRTFLNPATKSGDCS----VDLERKDICVGENGDDC- 551

  Fly   563 GSLPGSYSTDMDSPYGGASPGRIGGNMYGPQLEPEAENFGDYDDSRNGAVGGFEVGNLKGNIGNW 627
                            ..:|        .|..:..|  :.|:.........|..|
 Worm   552 ----------------NVTP--------DPLCKTTA--WSDWSPCSASCDEGVRV---------- 580

  Fly   628 ALNRQTNLGRDVPSLRPTNYDRARQQAEKSERTTWSGQSRPDDPRLEDVERAPWHRQRPSNKYGS 692
                :|.|      ...:.:::........|:.|...||                    ..::..
 Worm   581 ----RTRL------FFYSEHEKRCMHVNLQEKDTCVMQS--------------------CRRFIE 615

  Fly   693 IVEAPEMVSPREPWQRANNFGNPDMYTPGGDVDPSLSYRCFQMVQTAQPRCHDQTITGHFWFYNF 757
            |.........::..|.|.||                            ||         :| ||.
 Worm   616 INSEEICQEDKQAGQCAGNF----------------------------PR---------YW-YNH 642

  Fly   758 CADECMLYAADQCDRNVNKFRRWEDCEKCRQPGMAALQQEHTNSPQCEDF 807
            ...:|..:....|..|.|:|...|:|::...||....:....|:...|||
 Worm   643 EKTQCERFIFTGCKGNRNQFETEEECKQICLPGYEKSKSLIPNNQLLEDF 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30046	NP_725129.1	Reeler	28..167	CDD:260081	41/151 (27%)
		Spond_N	194..390	CDD:461924	77/195 (39%)
		TSP1	425..473	CDD:214559	18/47 (38%)
		TSP1_spondin	507..561	CDD:465948	23/57 (40%)
spon-1	NP_495473.2	Reeler	36..171	CDD:260081	38/140 (27%)
		Spond_N	197..388	CDD:461924	77/194 (40%)
		TSP1	435..481	CDD:214559	17/45 (38%)
		TSP1_spondin	497..547	CDD:480609	22/53 (42%)
		TSP1_spondin	559..610	CDD:480609	10/92 (11%)
		Kunitz_BPTI	621..672	CDD:425421	16/88 (18%)
		TSP1_spondin	706..758	CDD:465948
		TSP1_spondin	764..>785	CDD:480609
		TSP1	766..816	CDD:214559