DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30046 and SPON1

DIOPT Version :9

Sequence 1:	NP_001286341.1	Gene:	CG30046 / 36334	FlyBaseID:	FBgn0050046	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_006099.2	Gene:	SPON1 / 10418	HGNCID:	11252	Length:	807	Species:	Homo sapiens

Alignment Length:	709	Identity:	207/709 - (29%)
Similarity:	308/709 - (43%)	Gaps:	162/709 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PLVELLLLGSLVIGRV--SSLICTRRPANTGSPKSPVDENFMISVSGNPETYILGQEYNVSLNA- 69
            ||...|......:.:|  |...|:|.....|:.:....| |.:.|.|:|:.|..|..|.|:|:|
Human    22 PLAAALAFSDETLDKVPKSEGYCSRILRAQGTRREGYTE-FSLRVEGDPDFYKPGTSYRVTLSAA 85

  Fly    70 ----FNGHRYISFIMALENENGDFSYNDDLGRFELSDLIETRFSPNCINMVENTNTNSKTHMHLT 130
                |.|   .:.|...||..|| ...|..|.|::.|..||:|..||...|..:....:|.:.:.
Human    86 PPSYFRG---FTLIALRENREGD-KEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVF 146

  Fly   131 WVAPSEPGSGCVLIRATVQQHREVWHMDDGGLTKRICEE--VTDDVESQPTAPAAVDVPCCACDE 193
            |:|| ..|:|||:::|::.|.|.::..|:|.|||::||:  ..|.|..:|.      :.||||..
Human   147 WIAP-PAGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQDSTFDGVTDKPI------LDCCACGT 204

  Fly   194 ARYELIFEGVWSRNLHPKDFPTRG--WETRFCELLGAAHSSDYRFWESGELASVAMKEYAEHCSS 256
            |:|.|.|.|.||...||||:|.|.  |..    ::|.:||.:|..||.|..||..:|:.||..|.
Human   205 AKYRLTFYGNWSEKTHPKDYPRRANHWSA----IIGGSHSKNYVLWEYGGYASEGVKQVAELGSP 265

  Fly   257 RLLEREFSINFRDQKIRTIIKARG--PSYP--NISSKTMASVRVDPIHHMVSFASKIEPSPDWIV 317
            ..:|.|  |..:..::.|:|||:.  |::.  |:.:...|...||...|::||.:.:.|||||.|
Human   266 VKMEEE--IRQQSDEVLTVIKAKAQWPAWQPLNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNV 328

  Fly   318 GVTGLELCLRNCTWMEEKVINLYPWDVGTDSGPTYTSSDQPQVPPDVIRRMRSDFPNDPRSPFYD 382
            |::..:||.:.|.|:::.|.:|.|||.|||||.||.|.::|.:|.:.||.:.|  .:.|:|||||
Human   329 GLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTS--LDHPQSPFYD 391

  Fly   383 ISGTPMKPMAILTVKRQRIYERRC--------------ADEDSNNDPDVPRECFTHPWSSWSDCS 433
            ..|..:..:|.:.::|......:|              |.|:.:.| |.|..|....||.||.||
Human   392 PEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDED-DTPETCIYSNWSPWSACS 455

  Fly   434 S-----------------------------------------------------------KCGVG 439
            |                                                           .||:|
Human   456 SSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMG 520

  Fly   440 MQYRRRVYKQ-PELARVYNCNEAQYEERECQ-GEMCGQNN-LMREPEEFED--------LEPDPR 493
            |:.|.|..|| ||...|  |.....|..:|. .|.|..:: ||.|..|:::        ::...|
Human   521 MRSRERYVKQFPEDGSV--CTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHR 583

  Fly   494 RIGYQP-------SQQRRAE-----------CELSSWGSWSPCSVTCGDGYEMRQR--------- 531
            .|...|       ::..:||           |.||.|..||.||||||.|...|||
Human   584 MIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELG 648

  Fly   532 ----------QYLNPQAEFDCQGVHRMELQETRKCSGRDCLGSLPGSYSTDMDSPYGGA 580
                      :.:.|:...||:.....:..|..|..|:   |.:..:....|:..:|||
Human   649 DCNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGK---GHVIRTRMIQMEPQFGGA 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30046	NP_001286341.1	Reeler	28..167	CDD:260081	47/143 (33%)
		Spond_N	194..382	CDD:283999	75/193 (39%)
		TSP1	425..473	CDD:214559	22/108 (20%)
		TSP1	510..561	CDD:214559	20/69 (29%)
SPON1	NP_006099.2	Reeler	43..182	CDD:260081	47/144 (33%)
		Spond_N	205..392	CDD:310815	76/194 (39%)
		TSP_1	446..494	CDD:306574	7/47 (15%)
		TSP_1	505..554	CDD:306574	15/50 (30%)
		TSP_1	562..610	CDD:306574	7/47 (15%)
		TSP_1	618..665	CDD:306574	15/46 (33%)
		TSP_1	672..720	CDD:306574	8/36 (22%)
		TSP_1	758..807	CDD:306574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141173
Domainoid	1	1.000	184	1.000	Domainoid score	I3413
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	394	1.000	Inparanoid score	I1976
Isobase	1	0.950	-	0	Normalized mean entropy	S5564
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104958
Panther	1	1.100	-	-	O	PTHR11311
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2543
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.840