DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30046 and SPON2

DIOPT Version :9

Sequence 1:	NP_001286341.1	Gene:	CG30046 / 36334	FlyBaseID:	FBgn0050046	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_001121797.2	Gene:	SPON2 / 10417	HGNCID:	11253	Length:	331	Species:	Homo sapiens

Alignment Length:	328	Identity:	104/328 - (31%)
Similarity:	157/328 - (47%)	Gaps:	23/328 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LTKRICEEV--TDDVESQPTAPAAVDVPCCACDEARYELIFEGVWSRNLHPKDFPTRGWETRFCE 224
            |.|.:|..:  |.....||....::   |.|...|:|.:.|.|.||:...||.:|......::..
Human    10 LGKALCALLLATLGAAGQPLGGESI---CSARALAKYSITFTGKWSQTAFPKQYPLFRPPAQWSS 71

  Fly   225 LLGAAHSSDYRFWESGELASVAMKEYAEHCSSRLLEREF-SINFRDQKIRTIIKARGPSYPNISS 288
            ||||||||||..|...:..|..::::||...:..|.:|. :.....|.:..:..|  |:.|:.:.
Human    72 LLGAAHSSDYSMWRKNQYVSNGLRDFAERGEAWALMKEIEAAGEALQSVHAVFSA--PAVPSGTG 134

  Fly   289 KTMASVRVDPIHHMVSFASKIEPSPDWIVGVTGLELCLRNCTWMEEKVINLYPWDVGTDSGPTYT 353
            :|.|.:.|...|.:|||..:|.|||||.|||..|:|| ....|.|:..::|||:|.|||||.|::
Human   135 QTSAELEVQRRHSLVSFVVRIVPSPDWFVGVDSLDLC-DGDRWREQAALDLYPYDAGTDSGFTFS 198

  Fly   354 SSDQPQVPPDVIRRMRSDFPNDPRSPFYDISGTPMKPMAILTVKRQR------------IYERRC 406
            |.:...:|.|.:..:.|..|:.|.:.||......:.|:|.:|:.|.|            :..|..
Human   199 SPNFATIPQDTVTEITSSSPSHPANSFYYPRLKALPPIARVTLVRLRQSPRAFIPPAPVLPSRDN 263

  Fly   407 ADEDSNNDPDVPRECFTHPWSSWSDCSSKCG-VGMQYRRRVYKQPELARVYNCNEAQYEERECQG 470
            ...||.:.|:.|.:|....||||..|...|| :|.:.|.|..:.........|.|.: ||.||..
Human   264 EIVDSASVPETPLDCEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELE-EEAECVP 327

  Fly   471 EMC 473
            :.|
Human   328 DNC 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30046	NP_001286341.1	Reeler	28..167	CDD:260081	2/4 (50%)
		Spond_N	194..382	CDD:283999	67/188 (36%)
		TSP1	425..473	CDD:214559	16/48 (33%)
		TSP1	510..561	CDD:214559
SPON2	NP_001121797.2	Spond_N	41..228	CDD:399462	68/189 (36%)
SPON2	NP_001121797.2	TSP1_spondin	278..330	CDD:408798	17/52 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910