DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30046 and spon1

DIOPT Version :9

Sequence 1:	NP_001286341.1	Gene:	CG30046 / 36334	FlyBaseID:	FBgn0050046	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_001090741.1	Gene:	spon1 / 100036727	XenbaseID:	XB-GENE-991006	Length:	803	Species:	Xenopus tropicalis

Alignment Length:	796	Identity:	218/796 - (27%)
Similarity:	337/796 - (42%)	Gaps:	190/796 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 CTRRPANTGSPKSPVDENFMISVSGNPETYILGQEYNVSLNA-----FNGHRYISFIMALENENG 87
            |:|.....||.:......|.:.|.|:||.|..|..|.|:|.|     |.|...|:.....|.|..
Frog    39 CSRILRAQGSTRKEGYNEFSLRVEGDPEFYKPGNTYRVTLLAASPAYFRGFTLIALKEGKEGEKE 103

  Fly    88 DFSYNDDLGRFELSDLIETRFSPNCINMVENTNTNSKTHMHLTWVAPSEP-GSGCVLIRATVQQH 151
            :    |..|.|::.|..:|:|..||...|..:....:|.:.:.|.||  | |||||:::|::.|.
Frog   104 E----DHAGTFQIIDDEDTQFMSNCPVAVTESTPRRRTRIQVLWTAP--PIGSGCVILKASIVQK 162

  Fly   152 REVWHMDDGGLTKRICE-EVTDDVESQPTAPAAVDVPCCACDEARYELIFEGVWSRNLHPKDFPT 215
            :.::..|:|.||||:|| ::|.:..::...|     .||||..|:|.|.|.|.||...||||:|.
Frog   163 KIIYFQDEGSLTKRMCEPDLTLEGGNEKPIP-----DCCACGTAKYRLTFYGNWSEKTHPKDYPR 222

  Fly   216 RG--WETRFCELLGAAHSSDYRFWESGELASVAMKEYAEHCSSRLLEREFSINFRDQKIRTIIKA 278
            |.  |..    ::|.:||.:|..||.|..||..:|:.||..|...:|.|  |..:..::.|:|||
Frog   223 RANHWSA----IIGGSHSKEYVLWEYGGQASDGVKQVAELGSPVKMEEE--IRQKGDEVLTVIKA 281

  Fly   279 RG--PSYP--NISSKTMASVRVDPIHHMVSFASKIEPSPDWIVGVTGLELCLRNCTWMEEKVINL 339
            :.  |::.  |:.:...|...||...|::||.:.:.|||||.||::..:||.:.|.|:::.:.:|
Frog   282 KAQWPAWQPLNVRAAPSAEFSVDRSRHLMSFLAMMGPSPDWNVGLSSEDLCTKECGWVQKVIQDL 346

  Fly   340 YPWDVGTDSGPTYTSSDQPQVPPDVIRRMRSDFPNDPRSPFYDISGTPMKPMAILTVK------- 397
            .|||.|||||.||.|.::|.:|.|.||.:.|  .:.|:|||||..|.|:.|:|.:.::
Frog   347 IPWDAGTDSGVTYESPNKPSIPQDKIRPLTS--LDHPQSPFYDPEGGPIIPVARVVIERIARKGD 409

  Fly   398 ----------------------------------------------------RQRIYERR----- 405
                                                                |||:.:.:
Frog   410 QCNIVPDNVDDIVPDLVTEEKEEDDTPETCIYSNWSPWSACSSATCDKGKRMRQRMLKAQLDLSV 474

  Fly   406 ---------------CADEDSNNDPDVPRECFTHPWSSWSDCSSKCGVGMQYRRRVYKQ-PELAR 454
                           |:|::::.       |....|.:||.||:.||:||:.|.|..|| ||...
Frog   475 PCPDTQDFEPCMGPGCSDDEAST-------CMMSEWITWSPCSASCGMGMRSRERYVKQFPEDGS 532

  Fly   455 VYNCNEAQYEE----RECQGEMCGQNNLMREPEEFED--------LEPDPRRIGYQPSQQRRAE- 506
            :......:.|:    .||:...|    ::.|..|:|:        ::...|.|...|:.....:
Frog   533 MCKVPTEETEKCIVNEECEPSSC----IVTEWAEWEECSATCGMGMKKRHRMIKMTPADGSMCKA 593

  Fly   507 -----------------CELSSWGSWSPCSVTCGDGYEMRQRQYLNPQAEFDCQGVHRMELQETR 554
                             |.||.|..||.||||||.|...|||...:|....||    ..||::..
Frog   594 DTTEVEKCMMPECHTIPCVLSPWSEWSDCSVTCGKGTRTRQRMLKSPAELGDC----NEELKQVE 654

  Fly   555 KCSGRDCLGS---LPGSYSTDMDSPYGGASPGRIGGNMYGPQLEPEAENFGDYDDSRNGAVGGFE 616
            ||...:|..|   ...||.::.:...|       .|:|...::......||       |||....
Frog   655 KCMLPECPISCELTEWSYWSECNKSCG-------KGHMIRTRMITMEPQFG-------GAVCPET 705

  Fly   617 VGNLKGNIGNWALNRQTNLGRDVPSLRPTNYDRARQQAEKSERTTWSGQSRPDDPRLEDVERAPW 681
            |...|..:...    |.:.|.:...|:..   |.::::||::... .|:..|      ..:..||
Frog   706 VQRKKCRLRKC----QKSSGNERRRLKEA---REKRRSEKTKEDA-DGEQYP------VCKMKPW 756

  Fly   682 HRQRPSNKY--GSIVE 695
            .......|:  |.|.|
Frog   757 TAWTECTKFCGGGIQE 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30046	NP_001286341.1	Reeler	28..167	CDD:260081	47/144 (33%)
		Spond_N	194..382	CDD:283999	75/193 (39%)
		TSP1	425..473	CDD:214559	18/52 (35%)
		TSP1	510..561	CDD:214559	21/50 (42%)
spon1	NP_001090741.1	Reeler	38..178	CDD:260081	47/144 (33%)
		Spond_N	201..388	CDD:368927	76/194 (39%)
		TSP_1	442..490	CDD:365867	3/47 (6%)
		TSP_1	501..550	CDD:365867	16/48 (33%)
		TSP_1	558..606	CDD:365867	6/47 (13%)
		TSP_1	614..661	CDD:365867	21/50 (42%)
		TSP_1	668..716	CDD:365867	12/61 (20%)
		TSP_1	755..803	CDD:365867	6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3409
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	380	1.000	Inparanoid score	I2014
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11311
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2543
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160