DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17739 and Spon1

DIOPT Version :9

Sequence 1:	NP_610757.1	Gene:	CG17739 / 36333	FlyBaseID:	FBgn0033710	Length:	873	Species:	Drosophila melanogaster
Sequence 2:	NP_742064.2	Gene:	Spon1 / 64456	RGDID:	619918	Length:	807	Species:	Rattus norvegicus

Alignment Length:	898	Identity:	288/898 - (32%)
Similarity:	420/898 - (46%)	Gaps:	179/898 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IPRIEG-CIRVPPGVTAAKSPVDDNYV---LSVNGNTQSYVPGQRYNVSLSAFSGLSFISFMLAL 77
            :.:.|| |.|    :..|:....:.|.   |.|.|:...|.||..|.|:|||.....|..|.|..
  Rat    37 VAKSEGYCSR----ILRAQGTRREGYTEFSLRVEGDPDFYKPGSSYRVTLSAAPPSYFRGFTLIA 97

  Fly    78 DLESGDGDGDANALGTWEIADLAETRFSPRCPNLVENTNTNVKTRVDVFWVAPSSPGQGCILLRA 142
            ..|:.:||.:.:..||::|.|..||:|...||..|..:....:||:.|||:||.: |.||::|:|
  Rat    98 LKENREGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPT-GTGCVILKA 161

  Fly   143 TVMQHRDVWFMDDGFLTKRMCEEE--VDDIDTQPSIVDPCCACDEAKYELTFEGKWSRHTHPKDF 205
            :::|.|.::|.|:|.|||::||::  :|.:..:| |:| ||||..|||.|||.|.||..|||||:
  Rat   162 SIVQKRIIYFQDEGSLTKKLCEQDPTLDGVTDRP-ILD-CCACGTAKYRLTFYGNWSEKTHPKDY 224

  Fly   206 P--ANSWRTRFSDIIGASHTLDYRFWQYGELASEGLREVAEHGSTRTLESELKDQSEHIRTIIKA 268
            |  ||.|    |.|||.||:.:|..|:||..||||:::|||.||...:|.|::.||:.:.|:|||
  Rat   225 PRRANHW----SAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKA 285

  Fly   269 RGIAYP-----NVTGKTFAVFRVDSNHHLISLVSMVDPSPDWIVGVSGLELCLPNCSWVENKVHN 328
            :. .:|     ||.....|.|.||...||:|.::|:.|||||.||:|..:||...|.||:..|.:
  Rat   286 KA-QWPAWQPVNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQD 349

  Fly   329 LYPWDAGTDSGPSYMSADQPQVPPDVVRRIKSNFPNDPRSPFYDPTGAQMKPLATLHINRRRLYE 393
            |.|||||||||.:|.|.::|.:|.:.:|.:.|  .:.|:||||||.|..:..:|.:.|.|.....
  Rat   350 LIPWDAGTDSGVTYESPNKPTIPQEKIRPLTS--LDHPQSPFYDPEGGSITQVARVVIERIARKG 412

  Fly   394 KNC----------------ESSDSEQVPPECATNSWSRWDECTTK-CGPGKQYRIREFKNPALAS 441
            :.|                |..|.:..|..|..::||.|..|::. |..||:.|.|..| ..|..
  Rat   413 EQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCEKGKRMRQRMLK-AQLDL 476

  Fly   442 RHRCNNALREEKNCVGHKCAGFNEETAEGGEPEVAPSPGSSDD--PQCGLSDWSEWSSCTVTCGT 504
            ...|.:. ::.:.|:|                     ||.||:  ..|.:|:|..||.|:|:||.
  Rat   477 SVPCPDT-QDFQPCMG---------------------PGCSDEDGSTCTMSEWITWSPCSVSCGM 519

  Fly   505 GEMTRSRHYLNKKAKKKCQKASRARLHETKICEAMECGGDIENEGGAGEPEEEQAGGDGGGSAEK 569
            |..:|.|:     .|:..:..|...|                       |.||         .||
  Rat   520 GMRSRERY-----VKQFPEDGSVCML-----------------------PTEE---------TEK 547

  Fly   570 RSIFRNFESYSQHREDYIPPVCGVTPWSDFSPCMGPCG-GHGKRQRIRKVWNNNQVYGVTDPNDD 633
            .::          .|:..|..|.||.|.::..|...|| |..||.|:.|:          .|.|.
  Rat   548 CTV----------NEECSPSSCLVTEWGEWDDCSATCGMGMKKRHRMVKM----------SPADG 592

  Fly   634 GQDPCRHIKLHEEVNCTNPSCDTIVPGFCYDELTDSPCRDNDVANFWYYDHVSDQCAIYWSDRCD 698
            ..  |: .:..:...|..|.|.||            ||    :.:.|  ...|| |::.......
  Rat   593 SM--CK-AETSQAEKCMMPECHTI------------PC----LLSPW--SEWSD-CSVTCGKGMR 635

  Fly   699 TNRNKFKS-------KEECE--ETCRLPRHKQELQHDGIPAIDCLVSDWVSHS-CNASCGDGFQL 753
            |.:...||       .|:.|  |.|.||.         .| |||.:|:|...| ||.|||.|..:
  Rat   636 TRQRMLKSLAELGDCNEDLEQAEKCMLPE---------CP-IDCELSEWSQWSECNKSCGKGHMI 690

  Fly   754 RTRRVLRTPKYGGKPCPKHLVRLDRCYQRCDDMYSISGRGFGERRHVVRAPQPEPQDE------C 812
            |||.:...|::||.|||:.:.|.....::|....||....:.|.|...|:.|...:.:      |
  Rat   691 RTRTIQMEPQFGGAPCPETVQRKKCRARKCLRSPSIQKLRWREARESRRSEQLREESDGEQFPGC 755

  Fly   813 RYSEWSAWTPCTATCGDNAVRQRTRTLMNTDLSYK---CKDRVRMEKCVMMPC 862
            |...|:||:.||..|| ..:::|..|:.....|.:   |||:..:..|.:.||
  Rat   756 RMRPWTAWSECTKLCG-GGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17739	NP_610757.1	Reeler	23..163	CDD:260081	51/142 (36%)
		Spond_N	186..373	CDD:283999	91/193 (47%)
		TSP1	412..460	CDD:214559	14/48 (29%)
		TSP1	490..541	CDD:214559	14/50 (28%)
		KU	661..715	CDD:294074	12/62 (19%)
		TSP_1	815..862	CDD:278517	14/49 (29%)
Spon1	NP_742064.2	Reeler	43..182	CDD:260081	51/143 (36%)
		Spond_N	205..392	CDD:399462	91/193 (47%)
		TSP1_spondin	443..494	CDD:408798	16/73 (22%)
		TSP_1	505..554	CDD:395043	20/95 (21%)
		TSP_1	562..610	CDD:395043	15/60 (25%)
		TSP_1	618..665	CDD:395043	13/58 (22%)
		TSP1_spondin	669..720	CDD:408798	20/50 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..752		4/19 (21%)
		TSP1_spondin	755..807	CDD:408798	16/52 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334838
Domainoid	1	1.000	184	1.000	Domainoid score	I3320
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4453
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1893
OMA	1	1.010	-	-		QHG46443
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	1	1.000	-	-		otm44505
orthoMCL	1	0.900	-	-		OOG6_104958
Panther	1	1.100	-	-	LDO	PTHR11311
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2543
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910