DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17739 and RELN

DIOPT Version :9

Sequence 1:	NP_610757.1	Gene:	CG17739 / 36333	FlyBaseID:	FBgn0033710	Length:	873	Species:	Drosophila melanogaster
Sequence 2:	NP_005036.2	Gene:	RELN / 5649	HGNCID:	9957	Length:	3460	Species:	Homo sapiens

Alignment Length:	1059	Identity:	195/1059 - (18%)
Similarity:	306/1059 - (28%)	Gaps:	388/1059 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LSVNGNTQSYVPGQRYNVSLSA---FSGLSFISFMLALDLESGDGDGDANALGTWEIADLAETRF 104
            |.:.||...|||||.|:|::|.   |.||.......:..:::....|.::|.|   ...:::.:|
Human    59 LHIAGNPTYYVPGQEYHVTISTSTFFDGLLVTGLYTSTSVQASQSIGGSSAFG---FGIMSDHQF 120

  Fly   105 SPR--CPNLVENTNTNVKTRVDVFWVAPSSPGQGCILLRATVMQHRDVWFMDDGFLTKRMCEE-- 165
            ..:  |..:..:.:....|.:...|:||.: |.||:...||......|.|.|  .|.:::||:
Human   121 GNQFMCSVVASHVSHLPTTNLSFIWIAPPA-GTGCVNFMATATHRGQVIFKD--ALAQQLCEQGA 182

  Fly   166 -----------EV--------DDIDT------QPSIVDPCCACDEAKY----------------- 188
                       |:        ||.|:      .|:|...|..|:..:.
Human   183 PTDVTVHPHLAEIHSDSIILRDDFDSYHQLQLNPNIWVECNNCETGEQCGAIMHGNAVTFCEPYG 247

  Fly   189 --ELTFEGKWSRHTHPKDFPANSWRTRFSDIIGASHTLDYRFWQYGELASEGLREVAEHGSTRTL 251
              ||...|..:.......|...|...|||               |.:.:...|  .|::.|...:
Human   248 PRELITTGLNTTTASVLQFSIGSGSCRFS---------------YSDPSIIVL--YAKNNSADWI 295

  Fly   252 ESELKDQSEHIRTII-------KARGIAYPNV----------TGKTFA-------VFRVDSNHHL 292
            :.|......::.|||       .|:|   .||          .|:.:.       :..::|.|..
Human   296 QLEKIRAPSNVSTIIHILYLPEDAKG---ENVQFQWKQENLRVGEVYEACWALDNILIINSAHRQ 357

  Fly   293 ISLVSMVDP--SPDWIV--------------------GVSGLELCLPNC------------SWVE 323
            :.|...:||  :.:|:.                    |..|.|......            .|.|
Human   358 VVLEDSLDPVDTGNWLFFPGATVKHSCQSDGNSIYFHGNEGSEFNFATTRDVDLSTEDIQEQWSE 422

  Fly   324 NKVHNLYPWD---------AGT-DSGPSYM---SADQPQVPPDVVRRIKSNFPNDPRSPFYDPTG 375
            ........||         .|| :||.|.:   ..::....|.:......|.      .||...|
Human   423 EFESQPTGWDVLGAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNL------RFYFVMG 481

  Fly   376 AQMKPLATLHINRRRLYEK----------NCESSDSEQVP--------PECATNSWSRWDECTTK 422
            ....| ...|.|...||.|          :..|..|.:||        ||..|
Human   482 GICDP-GNSHENDIILYAKIEGRKEHITLDTLSYSSYKVPSLVSVVINPELQT------------ 533

  Fly   423 CGPGKQYRIREFKN-----------------PALAS---------------RHRCNNALREE--- 452
              |..::.:|: ||                 |.|.|               .|:..|::..|
Human   534 --PATKFCLRQ-KNHQGHNRNVWAVDFFHVLPVLPSTMSHMIQFSINLGCGTHQPGNSVSLEFST 595

  Fly   453 ----------KNCVGHKCAGFNEETAEGGEPEVAPSPGSSDDPQCGLSDWSEWSSCTVTCGTGEM 507
                      ..|:...|||          |.:..|...|.:      ::|.|:..|:......:
Human   596 NHGRSWSLLHTECLPEICAG----------PHLPHSTVYSSE------NYSGWNRITIPLPNAAL 644

  Fly   508 TRSRH-------------------YLNKKAKKKCQKASRARLHETKICEAMECGGDIENEGGAGE 553
            ||:..                   |:.....|.|....:...|..| |:.           |...
Human   645 TRNTRIRWRQTGPILGNMWAIDNVYIGPSCLKFCSGRGQCTRHGCK-CDP-----------GFSG 697

  Fly   554 PEEEQAG-------GDGGGSAEKRSIFRNFESYSQHREDYIPPVCGVTPWSDFSPCMGPC---GG 608
            |..|.|.       .:..||: :.|.:.||.|.   |...:...|||.       ..|..   ..
Human   698 PACEMASQTFPMFISESFGSS-RLSSYHNFYSI---RGAEVSFGCGVL-------ASGKALVFNK 751

  Fly   609 HGKRQRIRKVWNNNQ---------------VYGVTDPNDDGQDPCRHI--------KLHEE---V 647
            .|:||.|....:::|               :.....|:..|:....|.        ||.|.   :
Human   752 DGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRAPDQPGEGVLLHYSYDNGITWKLLEHYSYL 816

  Fly   648 NCTNPSCDTI-VPG-----------------------FCYDELTDSPCRDN----DVANF----- 679
            :...|...:: :||                       :..||:..:....|    |..|.
Human   817 SYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIMTSVLFNSISLDFTNLVEVTQ 881

  Fly   680 ---WYYDHVSDQCAIYWSDRCDTNRNKFKSKEECEETCRLPRHKQELQHDGIPAIDCLVSDWVSH 741
               :|..:|...|...|: .|.|..:|..|.....||       |.:|   |.|     |..:..
Human   882 SLGFYLGNVQPYCGHDWT-LCFTGDSKLASSMRYVET-------QSMQ---IGA-----SYMIQF 930

  Fly   742 SCNASCGDGFQLRTRRVLRTPKYGGKPCPKHLVRLDRC---YQRCDDMYSISGRGFGE----RRH 799
            |....||..:.......::...........|||: :.|   ...|.:..|.|.....|    ||.
Human   931 SLVMGCGQKYTPHMDNQVKLEYSTNHGLTWHLVQ-EECLPSMPSCQEFTSASIYHASEFTQWRRV 994

  Fly   800 VVRAPQPEPQDECRYSEWS 818
            :|..||.......|: .||
Human   995 IVLLPQKTWSSATRF-RWS 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17739	NP_610757.1	Reeler	23..163	CDD:260081	32/124 (26%)
		Spond_N	186..373	CDD:283999	43/276 (16%)
		TSP1	412..460	CDD:214559	11/92 (12%)
		TSP1	490..541	CDD:214559	11/69 (16%)
		KU	661..715	CDD:294074	15/65 (23%)
		TSP_1	815..862	CDD:278517	2/4 (50%)
RELN	NP_005036.2	Reeler	48..178	CDD:260081	32/124 (26%)
		Reelin_subrepeat_Nt	202..351	CDD:197344	28/168 (17%)
		Reelin_subrepeat_like	421..556	CDD:197448	30/156 (19%)
		Reelin_repeat_1_subrepeat_1	526..671	CDD:197345	26/175 (15%)
		BNR 1	592..603		1/10 (10%)
		EGF_2	<678..700	CDD:285248	6/33 (18%)
		Reelin_repeat_1_subrepeat_2	708..862	CDD:197353	27/164 (16%)
		BNR 2	798..809		1/10 (10%)
		Reelin_repeat_2_subrepeat_1	867..1034	CDD:197346	37/164 (23%)
		BNR 3	951..962		0/10 (0%)
		EGF_2	1031..1059	CDD:285248
		Reelin_repeat_2_subrepeat_2	1065..1220	CDD:197354
		BNR 4	1156..1167
		Reelin_repeat_3_subrepeat_1	1240..1409	CDD:197347
		BNR 5	1322..1333
		Reelin_repeat_3_subrepeat_2	1447..1597	CDD:197355
		BNR 6	1534..1545
		Reelin_repeat_4_subrepeat_1	1605..1774	CDD:197348
		BNR 7	1685..1696
		EGF_2	<1772..1794	CDD:285248
		Reelin_repeat_4_subrepeat_2	1800..1949	CDD:197356
		BNR 8	1883..1894
		Reelin_repeat_5_subrepeat_1	1956..2130	CDD:197349
		BNR 9	2042..2053
		EGF_2	2130..2159	CDD:285248
		Reelin_repeat_5_subrepeat_2	2165..2314	CDD:197357
		BNR 10	2249..2260
		Reelin_repeat_6_subrepeat_1	2322..2478	CDD:197350
		BNR 11	2398..2409
		Reelin_repeat_6_subrepeat_2	2514..2661	CDD:197358
		BNR 12	2597..2608
		Reelin_repeat_7_subrepeat_1	2669..2853	CDD:197351
		BNR 13	2777..2788
		EGF_2	2858..2882	CDD:285248
		Reelin_repeat_7_subrepeat_2	2889..3050	CDD:197359
		BNR 14	2978..2989
		Reelin_repeat_8_subrepeat_1	3055..3229	CDD:197352
		BNR 15	3142..3154
		EGF_2	3234..3258	CDD:285248
		Reelin_repeat_8_subrepeat_2	3266..3426	CDD:197360
		BNR 16	3362..3373
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S10216
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950