DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17739 and CG30046

DIOPT Version :9

Sequence 1:	NP_610757.1	Gene:	CG17739 / 36333	FlyBaseID:	FBgn0033710	Length:	873	Species:	Drosophila melanogaster
Sequence 2:	NP_001286341.1	Gene:	CG30046 / 36334	FlyBaseID:	FBgn0050046	Length:	839	Species:	Drosophila melanogaster

Alignment Length:	830	Identity:	361/830 - (43%)
Similarity:	478/830 - (57%)	Gaps:	126/830 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALVG--VIPRIEG--CIRVPPGVTAAKSPVDDNYVLSVNGNTQSYVPGQRYNVSLSAFSGLSFI 71
            |.|:|  ||.|:..  |.|.|....:.|||||:|:::||:||.::|:.||.|||||:||:|..:|
  Fly    12 LLLLGSLVIGRVSSLICTRRPANTGSPKSPVDENFMISVSGNPETYILGQEYNVSLNAFNGHRYI 76

  Fly    72 SFMLALDLESGDGDGDANALGTWEIADLAETRFSPRCPNLVENTNTNVKTRVDVFWVAPSSPGQG 136
            ||::||:.|:||...: :.||.:|::||.||||||.|.|:|||||||.||.:.:.|||||.||.|
  Fly    77 SFIMALENENGDFSYN-DDLGRFELSDLIETRFSPNCINMVENTNTNSKTHMHLTWVAPSEPGSG 140

  Fly   137 CILLRATVMQHRDVWFMDDGFLTKRMCEEEVDDIDTQ---PSIVD-PCCACDEAKYELTFEGKWS 197
            |:|:||||.|||:||.||||.||||:|||..||:::|   |:.|| ||||||||:|||.|||.||
  Fly   141 CVLIRATVQQHREVWHMDDGGLTKRICEEVTDDVESQPTAPAAVDVPCCACDEARYELIFEGVWS 205

  Fly   198 RHTHPKDFPANSWRTRFSDIIGASHTLDYRFWQYGELASEGLREVAEHGSTRTLESE----LKDQ 258
            |:.||||||...|.|||.:::||:|:.|||||:.|||||..::|.|||.|:|.||.|    .:||
  Fly   206 RNLHPKDFPTRGWETRFCELLGAAHSSDYRFWESGELASVAMKEYAEHCSSRLLEREFSINFRDQ 270

  Fly   259 SEHIRTIIKARGIAYPNVTGKTFAVFRVDSNHHLISLVSMVDPSPDWIVGVSGLELCLPNCSWVE 323
            .  |||||||||.:|||::.||.|..|||..||::|..|.::|||||||||:||||||.||:|:|
  Fly   271 K--IRTIIKARGPSYPNISSKTMASVRVDPIHHMVSFASKIEPSPDWIVGVTGLELCLRNCTWME 333

  Fly   324 NKVHNLYPWDAGTDSGPSYMSADQPQVPPDVVRRIKSNFPNDPRSPFYDPTGAQMKPLATLHINR 388
            .||.||||||.||||||:|.|:|||||||||:||::|:|||||||||||.:|..|||:|.|.:.|
  Fly   334 EKVINLYPWDVGTDSGPTYTSSDQPQVPPDVIRRMRSDFPNDPRSPFYDISGTPMKPMAILTVKR 398

  Fly   389 RRLYEKNCESSDSE---QVPPECATNSWSRWDECTTKCGPGKQYRIREFKNPALASRHRCNNALR 450
            :|:||:.|...||.   .||.||.|:.||.|.:|::|||.|.|||.|.:|.|.||..:.||.|..
  Fly   399 QRIYERRCADEDSNNDPDVPRECFTHPWSSWSDCSSKCGVGMQYRRRVYKQPELARVYNCNEAQY 463

  Fly   451 EEKNCVGHKCAGFN----EETAEGGEPE---VAPSPGSSDDPQCGLSDWSEWSSCTVTCGTGEMT 508
            ||:.|.|..|...|    .|..|..||:   :...|......:|.||.|..||.|:||||.|...
  Fly   464 EERECQGEMCGQNNLMREPEEFEDLEPDPRRIGYQPSQQRRAECELSSWGSWSPCSVTCGDGYEM 528

  Fly   509 RSRHYLNKKAKKKCQKASRARLHETKICEAMECGGDIENE---------GGAG------------ 552
            |.|.|||.:|:..||...|..|.||:.|...:|.|.:...         |||.
  Fly   529 RQRQYLNPQAEFDCQGVHRMELQETRKCSGRDCLGSLPGSYSTDMDSPYGGASPGRIGGNMYGPQ 593

  Fly   553 -EPEEEQAGG-----DGG-GSAEKRSIFRNFESYSQHREDYIPPVCGVTPWSDFSPCMGPCGGHG 610
             |||.|..|.     :|. |..|..::..|..:::.:|:         |......|.:.|.....
  Fly   594 LEPEAENFGDYDDSRNGAVGGFEVGNLKGNIGNWALNRQ---------TNLGRDVPSLRPTNYDR 649

  Fly   611 KRQRIRK----VWNNNQVYGVTDPNDDGQDPCRHIKLHEE------------------------- 646
            .||:..|    .|:     |.:.|:|...:.......|.:
  Fly   650 ARQQAEKSERTTWS-----GQSRPDDPRLEDVERAPWHRQRPSNKYGSIVEAPEMVSPREPWQRA 709

  Fly   647 VNCTNPSCDTIVPG---------FCYDEL-TDSP-CRDNDV-ANFWYYDHVSDQCAIYWSDRCDT 699
            .|..||  |...||         .|:..: |..| |.|..: .:||:|:..:|:|.:|.:|:||.
  Fly   710 NNFGNP--DMYTPGGDVDPSLSYRCFQMVQTAQPRCHDQTITGHFWFYNFCADECMLYAADQCDR 772

  Fly   700 NRNKFKSKEECEETCRLPRHKQELQHDGIPAIDCLVSDWVSHSCNASCGD 749
            |.|||:..|:||: ||.|         |:.|:.      ..|:.:..|.|
  Fly   773 NVNKFRRWEDCEK-CRQP---------GMAALQ------QEHTNSPQCED 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17739	NP_610757.1	Reeler	23..163	CDD:260081	81/139 (58%)
		Spond_N	186..373	CDD:283999	123/190 (65%)
		TSP1	412..460	CDD:214559	23/47 (49%)
		TSP1	490..541	CDD:214559	23/50 (46%)
		KU	661..715	CDD:294074	21/56 (38%)
		TSP_1	815..862	CDD:278517
CG30046	NP_001286341.1	Reeler	28..167	CDD:260081	81/139 (58%)
		Spond_N	194..382	CDD:283999	122/189 (65%)
		TSP1	425..473	CDD:214559	23/47 (49%)
		TSP1	510..561	CDD:214559	23/50 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438635
Domainoid	1	1.000	186	1.000	Domainoid score	I3283
eggNOG	1	0.900	-	-		E1_KOG3539
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2015
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104958
Panther	1	1.100	-	-	P	PTHR11311
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2543
	9	8.890